Montmorillonite modified by CNx supported Pt for methanol oxidation

A composite support based on nature clay, i.e. montmorillonite (MMT), shows great promise as support materials for Pt electrocatalyst for the methanol oxidation reaction in fuel cell anodes. The reported composite support (CNx-MMT) was prepared via carbonizing MMT which was covered by N-contented polymer. X-ray diffraction and transmission electron microscopy results showed that Pt nanoparticles can be well-dispersed on the composite support with highly dispersed tiny crystal Pt nanoparticles. Cyclic voltammetry measurements showed that the Pt/CNx-MMT has the enhanced electrocatalytic activity in methanol oxidation reaction. The developed Pt catalyst supported on new composite support is catalytically more active for methanol electrooxidation than Pt supported on the conventional carbon support and shows good stability, offering promising potential for application of MMT as support for fuel cell electrocatalysis.Web of Scienc

Draft genome sequence of the mulberry tree Morus notabilis

Human utilization of the mulberry–silkworm interaction started at least 5,000 years ago and greatly influenced world history through the Silk Road. Complementing the silkworm genome sequence, here we describe the genome of a mulberry species Morus notabilis. In the 330-Mb genome assembly, we identify 128 Mb of repetitive sequences and 29,338 genes, 60.8% of which are supported by transcriptome sequencing. Mulberry gene sequences appear to evolve ~3 times faster than other Rosales, perhaps facilitating the species’ spread worldwide. The mulberry tree is among a few eudicots but several Rosales that have not preserved genome duplications in more than 100 million years; however, a neopolyploid series found in the mulberry tree and several others suggest that new duplications may confer benefits. Five predicted mulberry miRNAs are found in the haemolymph and silk glands of the silkworm, suggesting interactions at molecular levels in the plant–herbivore relationship. The identification and analyses of mulberry genes involved in diversifying selection, resistance and protease inhibitor expressed in the laticifers will accelerate the improvement of mulberry plants

A New Silicon Dioxide-Coated MALDI-ToF Sample Plate for Peptide Analysis

In this report, we describe the development and testing of a new coated plate which improves the sensitivity and accuracy in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF-MS). The coated plate was covered with a thin layer of hydrophobic silicon dioxide, which enabled sample enrichment due to the water repellent nature of the silicon dioxide surface. Sensitivity and required laser strengths were tested using peptide standards, with the results that these coated plates required lower laser power and showed increased sensitivity than that of common plates. Accuracy was tested using bacteria, saliva, and serum samples. The coated plates showed significantly increased degrees of accuracy through their capacity to reduce mass shift. The importance and necessity of accuracy analysis in the assessment of new sample plates, which is rarely described in other papers, is also discussed

A Comparative Study on the Cam Relationship for the Optimal Vibration and Efficiency of a Kaplan Turbine

Kaplan turbines are generally used in working conditions with a high flow and low head. These are a type of axial-flow hydro turbine that can adjust the opening of the guide vanes and blades simultaneously in order to achieve higher efficiency under a wider range of loads. Different combinations of the opening of the guide vanes and blades (cam relationship) will lead to changes in the efficiency of the turbine unit as well as its vibration characteristics. A bad cam relationship will cause the low efficiency or unstable operation of the turbine. In this study, the relative efficiency and vibration of a large-scale Kaplan turbine with 200 MW output were tested with different guide vane and blade openings. The selection of the cam relationship curve for both optimal efficiency and optimal vibration is discussed. Compared with the cam relationship given by the model test, the prototype cam relationship improves the efficiency and reduces the vibration level. Compared to the optimal efficiency cam relationship, the optimal vibration cam relationship reduces the efficiency of the machine by 1% to 2%, while with the optimal efficiency cam relationship, the vibration of the unit increases significantly. This research provides guidance for the optimization of the regulation of a large adjustable-blade Kaplan turbine unit and improves the overall economic benefits and safety performance of the Kaplan turbine power station

Exploring temporal trends and burden of traumatic shoulder dislocation: a global perspective

ObjectiveTo explore the geographical and temporal trends of traumatic shoulder dislocation, describe the association between the social and demographic factors and the health burden due to traumatic shoulder dislocation, and further investigate its causes.MethodsData on traumatic shoulder dislocation was collected from the Global Burden of Disease 2019, spanning the years 1990 to 2019. The epidemiology and disease burden were examined at global, regional, and national levels. Additionally, the age and gender patterns were analyzed, followed by an investigation into the primary causes. Lastly, the study studied the correlation between age-standardized rates and the socio-demographic index (SDI).ResultsOver a span of 30 years, both the crude and age-standardized rates of incidence and years lived with disability (YLDs) rates for all genders displayed a slight fluctuating downward trend. The incidence and YLDs rates in males were consistently higher than those in females. The study analyzed both incidence and YLDs rates of the global, regional, and national of traumatic shoulder dislocations from 1990 to 2019, as well as the temporal trends. Among males, the highest incidence rate was observed in young adulthood, while females exhibited the highest incidence rate in old age. This pattern was mirrored in the YLDs rate. Falls were identified as the main cause contributing to the disease burden related to traumatic shoulder dislocations. Moreover, a positive correlation was found between the age-standardized rates and SDI.ConclusionThe disease burden of traumatic shoulder dislocation has not significantly decreased from 1990 to 2019. The incidence and YLD rates are associated with age, gender, and SDI. A thorough examination of the disease burden contributes to the efficient allocation and utilization of resources, as well as the development of targeted and effective intervention strategies

Table_1_Exploring temporal trends and burden of traumatic shoulder dislocation: a global perspective.DOCX

ObjectiveTo explore the geographical and temporal trends of traumatic shoulder dislocation, describe the association between the social and demographic factors and the health burden due to traumatic shoulder dislocation, and further investigate its causes.MethodsData on traumatic shoulder dislocation was collected from the Global Burden of Disease 2019, spanning the years 1990 to 2019. The epidemiology and disease burden were examined at global, regional, and national levels. Additionally, the age and gender patterns were analyzed, followed by an investigation into the primary causes. Lastly, the study studied the correlation between age-standardized rates and the socio-demographic index (SDI).ResultsOver a span of 30 years, both the crude and age-standardized rates of incidence and years lived with disability (YLDs) rates for all genders displayed a slight fluctuating downward trend. The incidence and YLDs rates in males were consistently higher than those in females. The study analyzed both incidence and YLDs rates of the global, regional, and national of traumatic shoulder dislocations from 1990 to 2019, as well as the temporal trends. Among males, the highest incidence rate was observed in young adulthood, while females exhibited the highest incidence rate in old age. This pattern was mirrored in the YLDs rate. Falls were identified as the main cause contributing to the disease burden related to traumatic shoulder dislocations. Moreover, a positive correlation was found between the age-standardized rates and SDI.ConclusionThe disease burden of traumatic shoulder dislocation has not significantly decreased from 1990 to 2019. The incidence and YLD rates are associated with age, gender, and SDI. A thorough examination of the disease burden contributes to the efficient allocation and utilization of resources, as well as the development of targeted and effective intervention strategies.</p

The rs2147578 C > G polymorphism in the Inc-LAMC2–1:1 gene is associated with increased neuroblastoma risk in the Henan children

Abstract Background The rs2147578 C > G polymorphism in the long non-coding RNA gene Lnc-LAMC2–1:1 is associated with increased susceptibility to a few types of cancers. However, its role in neuroblastoma has not been evaluated yet. Methods We investigated the association between the lnc-LAMC2–1:1 rs2147578 C > G polymorphism and neuroblastoma susceptibility in Chinese Han populations. A total of 393 neuroblastoma cases and 812 healthy individuals from the Henan and Guangdong provinces were enrolled and subjected to genotyping. Odds ratio (OR) and 95% confidence interval (CI) were used to determine the strength of the association of interest. Results Combined analysis revealed that the lnc-LAMC2–1:1 rs2147578 C > G polymorphism was associated with increased neuroblastoma susceptibility (CG vs. CC: adjusted OR = 1.33, 95% CI = 1.01–1.75, P = 0.045; CG/GG vs. CC: adjusted OR = 1.34, 95% CI = 1.03–1.74, P = 0.028). In stratification analysis, children under 18 months with rs2147578 CG/GG genotypes had an increased neuroblastoma risk (adjusted OR = 1.70, 95% CI = 1.08–2.67, P = 0.022). Females with rs2147578 CG/GG genotypes also had increased neuroblastoma susceptibility (adjusted OR = 2.08, 95% CI = 1.37–3.18, P = 0.0007). In addition, children with lnc-LAMC2–1:1 rs2147578 CG/GG genotypes were prone to develop earlier stages of neuroblastoma (adjusted OR = 1.46, 95% CI = 1.01–2.12, P = 0.046). Conclusions The Lnc-LAMC2–1:1 rs2147578 C > G polymorphism may contribute to increased neuroblastoma susceptibility in children of Henan province

Enhanced Antimicrobial Activity of N-Terminal Derivatives of a Novel Brevinin-1 Peptide from The Skin Secretion of Odorrana schmackeri

Antimicrobial peptides (AMPs) are promising therapeutic alternatives compared to conventional antibiotics for the treatment of drug-resistant bacterial infections. However, the application of the overwhelming majority of AMPs is limited because of the high toxicity and high manufacturing costs. Amphibian skin secretion has been proven to be a promising source for the discovery and development of novel AMPs. Herein, we discovered a novel AMP from the skin secretion of Odorrana schmackeri, and designed the analogues by altering the key factors, including conformation, net charge and amphipathicity, to generate short AMPs with enhanced therapeutic efficacy. All the peptides were chemically synthesised, followed by evaluating their biological activity, stability and cytotoxicity. OSd, OSe and OSf exhibited broad-spectrum antibacterial effects, especially OSf, which presented the highest therapeutic index for the tested bacteria. Moreover, these peptides displayed good stability. The results from scanning electron microscopy and transmission electron microscopy studies, indicated that brevinin-OS, OSd, OSe and OSf possessed rapid bactericidal ability by disturbing membrane permeability and causing the release of cytoplasmic contents. In addition, OSd, OSe and OSf dramatically decreased the mortality of waxworms acutely infected with MRSA. Taken together, these data suggested that a balance between positive charge, degrees of &alpha;-helicity and hydrophobicity, is necessary for maintaining antimicrobial activity, and these data successfully contributed to the design of short AMPs with significant bactericidal activity and cell selectivity

Comparison of satellite-based evapotranspiration models over terrestrial ecosystems in China

Evapotranspiration (ET) is a key component of terrestrial ecosystems because it links the hydrological, energy, and carbon cycles. Several satellite-based ET models have been developed for extrapolating local observations to regional and global scales, but recent studies have shown large model uncertainties in ET simulations. In this study, we compared eight ET models, including five empirical and three process-based models, with the objective of providing a reference for choosing and improving methods. The results showed that the eight models explained between 61 and 80% of the variability in ET at 23 eddy covariance towers in China and adjacent regions. The mean annual ET for all of China varied from 535 to 852 mm yr− 1 among the models. The interannual variability of yearly ET varied significantly between models during 1982–2009 because of different model structures and the dominant environmental factors employed. Our evaluation results showed that the parameters of the empirical methods may have different combination because the environmental factors of ET are not independent. Although the three process-based models showed high model performance across the validation sites, there were substantial differences among them in the temporal and spatial patterns of ET, the dominant environment factors and the energy partitioning schemes. The disagreement among current ET models highlights the need for further improvements and validation, which can be achieved by investigating model structures and examining the ET component estimates and the critical model parameters