Additional file 1: of Efficacy and safety of auricular point acupressure treatment for gastrointestinal dysfunction after laparoscopic cholecystectomy: study protocol for a randomized controlled trial

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Boron Trifluoride Etherate Functioning as a Fluorine Source in an Iodosobenzene-Mediated Intramolecular Aminofluorination of Homoallylic Amines

A widely used Lewis acid BF₃·Et₂O was shown to be capable of acting as an efficient fluorinating agent in an intramolecular aminofluorination reaction of homoallylic amines to provide 3-fluoropyrrolidines mediated by a commercially available hypervalent iodine­(III) reagent PhIO at room temperature. A mechanism involving a carbocation intermediate was proposed on the basis of several experimental evidence

Boron Trifluoride Etherate Functioning as a Fluorine Source in an Iodosobenzene-Mediated Intramolecular Aminofluorination of Homoallylic Amines

A widely used Lewis acid BF₃·Et₂O was shown to be capable of acting as an efficient fluorinating agent in an intramolecular aminofluorination reaction of homoallylic amines to provide 3-fluoropyrrolidines mediated by a commercially available hypervalent iodine­(III) reagent PhIO at room temperature. A mechanism involving a carbocation intermediate was proposed on the basis of several experimental evidence

Boron Trifluoride Etherate Functioning as a Fluorine Source in an Iodosobenzene-Mediated Intramolecular Aminofluorination of Homoallylic Amines

A widely used Lewis acid BF₃·Et₂O was shown to be capable of acting as an efficient fluorinating agent in an intramolecular aminofluorination reaction of homoallylic amines to provide 3-fluoropyrrolidines mediated by a commercially available hypervalent iodine­(III) reagent PhIO at room temperature. A mechanism involving a carbocation intermediate was proposed on the basis of several experimental evidence

Supplementary material for genetic links between metabolic syndrome and osteoarthritis: insights from cross-trait analysis

Background: Previous observational studies have indicated a bidirectional association between metabolic syndrome (MetS) and osteoarthritis (OA). However, it remains unclear whether these bidirectional associations reflect causal relationships or shared genetic factors, and the underlying biological mechanisms of this association are not fully understood. Methods: Leveraging summary statistics from genome-wide association studies (GWASs) conducted by the UK Biobank and the Glucose and Insulin-related Traits Consortium (MAGIC), we performed global genetic correlation analyses, genome-wide cross-trait meta-analyses, and a bidirectional two-sample Mendelian randomization analyses using summary statistics from GWASs to comprehensively assess the relationship of MetS and OA.Results: We first detected an extensive genetic correlation between MetS and OA (rg=0.393, P=1.52×10-18), which was consistent in four MetS components, including waist circumference, triglycerides, hypertension and high-density lipoprotein cholesterol and OA with rg ranging from -0.229 to 0.490. We then discovered 32 variants jointly associated with MetS and OA through multi-trait Analysis of GWAS. Co-localization analysis founded 12 genes shared between MetS and OA, with functional implications in several biological pathways. Finally, MR analysis suggested genetic liability to MetS significantly increased the risk of OA, but no reverse causality was found.Conclusion: Our results illustrate a common genetic architecture, pleiotropic loci, as well as causality between MetS and OA, potentially enhancing our knowledge of high comorbidity and genetic processes that overlap between the two disorders.</p

Temperature-Induced Syntheses, Iodine Elimination, Enantiomers Resolution, and Single-Crystal-to-Single-Crystal Transformation of Imidazole-Co(II) Coordination Polymers with Amino-isophthalic Acid as Co-Ligand

On the basis of a temperature-induced effect, the solvothermal reaction of Co­(Ac)₂·4H₂O, 5-amino-2,4,6-triiodoisophthalic acid (H₂atibdc), and 1,4-bis­(2-methyl-imidazol-1-yl)­butane (bib) at 80 °C gave a new coordination polymer [Co­(bib)­(atibdc)] (<b>1</b>), which shows a two-dimensional (2D) network with left- and right-handed helical chains. By raising the reaction temperature to 130 °C, a pair of homochiral enantiomers [Co­(bib)­(atibdc)]­·2H₂O (<b>2</b>, <b>2M</b>, and <b>2P</b>) were successfully obtained, displaying a three-dimensional (3D) framework with three kinds of unique helical chains. Keeping the temperature of the reaction system to 150 °C, excited, an in situ iodine elimination reaction occurred, and a new linker 5-aminoisophthalic acid (H₂aipa) was generated, which then cooperated with the bib ligand to construct a coordination polymer [Co­(bib)­(aipa)] (<b>3</b>), showing a 3D 3-fold interpenetrating architecture. The comparison of final solid structures exhibits an exclusive temperature-induced effect on the construction of the coordination polymer. Furthermore, via a single-crystal-to-single-crystal (SCSC) transformation, the 2D network of <b>1</b> can be derived from the 3D framework of <b>2</b>, which presents a rare type of temperature-solvent induced SCSC transformation. In addition, the magnetic properties of <b>1</b>–<b>3</b> have been investigated as well

Synthesis and structures of a series of d¹⁰ coordination compounds based on flexible bis(imidazole) ligand and dicarboxylates

<p>A series of new coordination compounds based on 1,6-bis(2-methyl-imidazole-yl)-hexane (bimh), namely [Zn(bimh)_0.5(chda)]_n (<b>1</b>), {[Cd(bimh)_0.5(bda)]·H₂O}_n (<b>2</b>), [Cd(bimh)(oba)]_n (<b>3</b>), [Zn(bimh)(oba)]_n (<b>4</b>), [Cd(bimh)(ipa)]_n (<b>5</b>), {[Zn(bimh)_0.5(ipa)]·H₂O}_n (<b>6</b>), (bimh  =  1,6-bis(2-methyl-imidazole-1-yl)hexane, H₂chda  =  1,4-cyclohexanedicarboxylic acid, H₂bda  =  2,2′-biphenyldicarboxylic acid, H₂oba  =  4,4′-oxybis(benzoic acid), and H₂ipa  =  isophthalic acid) have been synthesized by solvothermal route and diffusion method and characterized by elemental analysis, IR spectroscopy, single-crystal X-ray diffraction technology. Compound <b>1</b> affords a two-dimensional (2D) wave-like framework with dinuclear paddle-wheel units, where the structures are further assembled via aromatic π–π stacking to generate a 3D network. Compound <b>2</b> exhibits a 1D ladder chain, which is further linked by hydrogen bonds to form a 2D architecture. Compounds <b>3</b> and <b>4</b> are isostructural, possessing a 2D layer network based on hydrogen bonds. Compound <b>5</b> displays a 2D wave-like layer structure. Compound <b>6</b> has a 1D line chain structure, which is packed into a 3D supermolecule network by two types of hydrogen bonds. Furthermore, the thermal stabilities and photoluminescent properties for compounds <b>1</b>–<b>6</b> were investigated.</p