Effect of insulin pump infusion on comprehensive stress state of patients with diabetic ketoacidosis

Purpose: To assess changes in the comprehensive stress state of patients with diabetic ketoacidosis (DKA) following treatment with insulin infusion pump.Methods: A total of 240 patients suffering from DKA who received treatment at The First Affiliated Hospital of Zhengzhou University from Feb. 2011 to Feb. 2014 were selected randomly and divided into a control group (120 cases), administered continuous intravenous insulin, and a treatment group (120 cases), administered insulin with an infusion pump. Relevant diabetes-associated serum indices, oxidative stress and stress hormone levels were compared between the groups at different time points.Results: Levels of glycosylated haemoglobin (HbAlc), fasting blood glucose (FBG) and anion gap (AG) were lower (p < 0.05) in the treatment group than in the control group at various time points. Carbon dioxide combining power (CO2-CP) and C-reactive peptide levels in the treatment group were higher (p < 0.05) than those of the control group at different time points. Except for the level of methane dicarboxylic aldehyde (MDA), the values of other oxidative stress indices were higher (p < 0.05) in the treatment group than in the control group at various time points. Moreover, the treatment group had lower serum cortisol (Cor) and noradrenalin (NA) levels and higher levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) than those of (p < 0.05).Conclusion: Insulin pump infusion effectively relieves the comprehensive stress state of patients suffering from DKA, and its therapeutic effect is superior to that of continuous instillation of low-dose insulin.Keywords: Diabetic ketoacidosis, Insulin pump, Comprehensive stress state, Blood glucose, Carbon dioxide combining power, C-reactive peptid

Effect of Baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis

Objective: To investigate the effect of Bacailin on inflammatory mediator levels and microcirculation disturbance in severe acute pancreatitis (SAP) rats and explore its therapeutic mechanism on this disease. Methods: SAP model rats were randomly divided into model control group and Baicalin treated group, 45 rats in each group. The same number of normal rats were included in sham-operated group. These groups were further subdivided into 3 h, 6 h and 12 h subgroups, respectively (15 rats in each subgroup). At 3, 6 and 12 hours after operation, rats were killed to conduct the following experiments: (1) to examine the mortality rates of rats, the ascites volume and pancreatic pathological changes in each group; (2) to determine the contents of amylase, PLA~2~, TXB~2~, PGE~2~, PAF and IL-1[beta]; in blood as well as the changes in blood viscosity.Results: (1) Compared to model control group, treatment with Baicalin is able to improve the pathological damage of the pancreas, lower the contents of amylase and multiple inflammatory mediators in blood, decrease the amount of ascitic fluid and reduce the mortality rates of SAP rats; (2) at 3 hours after operation, the low-shear whole blood viscosity in Baicalin treated group was significantly lower than that in model control group;at 12 hours after operation, both the high-shear and low-shear whole blood viscosity in Baicalin treated group were also significantly lower than those in model control group.Conclusion: Baicalin, as a new drug, has good prospects in the treatment of SAP since it can exert therapeutic effects on this disease through inhibiting the production of inflammatory mediators, lowering blood viscosity, improving microcirculation and mitigating the pathological damage of the pancreas

Simple, Time-Saving Dye Staining of Proteins for Sodium Dodecyl Sulfate–Polyacrylamide Gel Electrophoresis Using Coomassie Blue

A fixation-free and fast protein-staining method for sodium dodecyl sulfate–polyacrylamide gel electrophoresis using Coomassie blue is described. The protocol comprises staining and quick washing steps, which can be completed in 0.5 h. It has a sensitivity of 10 ng, comparable with that of conventional Coomassie Brilliant Blue G staining with phosphoric acid in the staining solution. In addition, the dye stain does not contain any amount of acid and methanol, such as phosphoric acid. Considering the speed, simplicity, and low cost, the dye stain may be of more practical value than other dye-based protein stains in routine proteomic research

Non-Abelian dynamical gauge field and topological superfluids in optical Raman lattice

We propose an experimental scheme to realize non-Abelian dynamical gauge field for ultracold fermions, which induces a novel pairing mechanism of topological superfluidity. The dynamical gauge fields arise from nontrivial interplay effect between the strong Zeeman splitting and Hubbard interaction in a two-dimensional (2D) optical Raman lattice. The spin-flip transitions are forbidden by the large Zeeman detuning, but are restored when the Zeeman splitting is compensated by Hubbard interaction. This scheme allows to generate a dynamical non-Abelian gauge field that leads to a Dirac type correlated 2D spin-orbit interaction depending on local state configurations. The topological superfluid from a novel pairing driven by 2D dynamical gauge fields is reached, with analytic and numerical results being obtained. Our work may open up a door to emulate non-Abelian dynamical gauge fields and correlated topological phases with experimental feasibility.Comment: 5+7 pages, 4+6 figure

Estimating the crop leaf area index using hyperspectral remote sensing

AbstractThe leaf area index (LAI) is an important vegetation parameter, which is used widely in many applications. Remote sensing techniques are known to be effective but inexpensive methods for estimating the LAI of crop canopies. During the last two decades, hyperspectral remote sensing has been employed increasingly for crop LAI estimation, which requires unique technical procedures compared with conventional multispectral data, such as denoising and dimension reduction. Thus, we provide a comprehensive and intensive overview of crop LAI estimation based on hyperspectral remote sensing techniques. First, we compare hyperspectral data and multispectral data by highlighting their potential and limitations in LAI estimation. Second, we categorize the approaches used for crop LAI estimation based on hyperspectral data into three types: approaches based on statistical models, physical models (i.e., canopy reflectance models), and hybrid inversions. We summarize and evaluate the theoretical basis and different methods employed by these approaches (e.g., the characteristic parameters of LAI, regression methods for constructing statistical predictive models, commonly applied physical models, and inversion strategies for physical models). Thus, numerous models and inversion strategies are organized in a clear conceptual framework. Moreover, we highlight the technical difficulties that may hinder crop LAI estimation, such as the “curse of dimensionality” and the ill-posed problem. Finally, we discuss the prospects for future research based on the previous studies described in this review

High Dose ESAs Are Associated with High iPTH Levels in Hemodialysis Patients with End-Stage Kidney Disease: A Retrospective Analysis

Objective: Anemia and secondary hyperparathyroidism are the two most common complications associated with chronic kidney disease (CKD). Erythropoiesis-stimulating agents (ESAs) are widely used in the management of anemia in hemodialysis patients. A reverse correlation has been established between hyperparathyroidism and hemoglobin levels. The aim of this retrospective study is to evaluate the relationship of high dose ESAs and hyperparathyroidism in hemodialysis patients with anemia. Methods: A total of 240 uremic patients maintained on regular hemodialysis were enrolled into this study. Among them, 142 patients were treated with Epiao® (epoetin-alfa) and 98 patients were treated with Recormon® (epoetin-beta). The target hemoglobin concentration was 110-130 g/L. Laboratory measurements including hemoglobin, calcium, phosphorus, albumin, intact-parathyroid hormone (iPTH), serum ferritin and transferrin saturation were collected. Results: Hemoglobin concentration increased as iPTH level decreased by stratification. However, no significant association between anemia and calcium or phosphorus level was found. Patients with iPTH levels within 150-300 pg/mL had the highest levels of hemoglobin, serum ferritin and transferrin saturation. Patients treated with Recormon and Epiao had similar hemoglobin concentrations. However, the dose of Recormon for anemia treatment was significantly less than that the dose of Epiao (P<0.05). The level of iPTH in the Recormon group was significantly lower than in the Epiao group. In patients with hemoglobin levels between 110-130 g/L (P<0.05), iPTH level was found to be significantly lower in patients treated with lower doses of ESAs than in patients treated with higher doses of ESAs, no matter which ESA was used (Recormon or Epiao, P<0.05). Conclusions: The dose of ESAs might be positively associated with iPTH level, suggesting that a reasonable hemoglobin target can be achieved by using the lowest possible ESA dose

A Theoretically Guaranteed Quaternion Weighted Schatten p-norm Minimization Method for Color Image Restoration

Inspired by the fact that the matrix formulated by nonlocal similar patches in a natural image is of low rank, the rank approximation issue have been extensively investigated over the past decades, among which weighted nuclear norm minimization (WNNM) and weighted Schatten $p$-norm minimization (WSNM) are two prevailing methods have shown great superiority in various image restoration (IR) problems. Due to the physical characteristic of color images, color image restoration (CIR) is often a much more difficult task than its grayscale image counterpart. However, when applied to CIR, the traditional WNNM/WSNM method only processes three color channels individually and fails to consider their cross-channel correlations. Very recently, a quaternion-based WNNM approach (QWNNM) has been developed to mitigate this issue, which is capable of representing the color image as a whole in the quaternion domain and preserving the inherent correlation among the three color channels. Despite its empirical success, unfortunately, the convergence behavior of QWNNM has not been strictly studied yet. In this paper, on the one side, we extend the WSNM into quaternion domain and correspondingly propose a novel quaternion-based WSNM model (QWSNM) for tackling the CIR problems. Extensive experiments on two representative CIR tasks, including color image denoising and deblurring, demonstrate that the proposed QWSNM method performs favorably against many state-of-the-art alternatives, in both quantitative and qualitative evaluations. On the other side, more importantly, we preliminarily provide a theoretical convergence analysis, that is, by modifying the quaternion alternating direction method of multipliers (QADMM) through a simple continuation strategy, we theoretically prove that both the solution sequences generated by the QWNNM and QWSNM have fixed-point convergence guarantees.Comment: 46 pages, 10 figures; references adde