Investigating the elements influencing the psychological issues of reform school students

Reformatory students are those whose deviant behaviors and habits prevent them from receiving education under normal educational conditions. These students frequently lead a careless, undisciplined lifestyle, being unwilling to work and learn eager to play and demanding. Therefore, when they are admitted to reformatories with severe study and lifestyle requirements, they have great psychological difficulty adjusting to their new environment. Students’ psychological issues in adapting to reformatory learning and living regimes are difficult and psychological deficits make it challenging for students to adapt to reformatory learning and living conditions. In Vietnam, 665 students from reformatory schools were polled to determine the causes of psychological issues. According to the findings, a variety of elements contribute to students’ psychological difficulties. Individual student conditions such as health, awareness, attitudes and actions as well as inappropriate habits, living without goals or aspirations, etc. are on the subjective side of the equation. On the objective side are the students’ conditions, family, education and psychological obstacles brought on by less-than-ideal circumstances which will make it more difficult for community students to adapt. Both the new school and society must pay more attention to reformatory students in order to establish the conditions necessary for successful integration into the new school and ultimate readmission into society for these students

The politics of numbers and additionality governing the national Payment for Forest Environmental Services scheme in Vietnam: A case study from Son La province

Payments for forest environmental services (PFES) is a major breakthrough policy in the Vietnamese forestry sector because it contributes 25% of the total investments in the forestry sector and serves as the first market-based instrument employed to protect forests. However, there is little empirical evidence of its effectiveness. Is the policy meeting the core objectives of improving forest cover and forest quality and is it also achieving its claims of supporting local livelihoods? This paper analyses the environmental, social, and economic impacts of PFES in Son La province, the longest standing implementation of a PFES scheme in Vietnam. Our study uses a sampling method that incorporates pre-matching and a before-after-control-intervention approach. Data was collected from government statistics, remote sensing analysis, focus group discussions involving 236 people, surveys with a total of 240 households, and key informant interviews with 45 people. Our findings show that additionality of PFES in Son La is controversial and depends on who collects the data and what data is used to evaluate the impacts of PFES. Data collection is also politicized to serve central, provincial and district government interests. Evidence shows that PFES has provided little additional income to individual villagers to protect forests in Son La. However, total PFES revenue paid to communities generates significant income for village communities. Moreover, not all villagers can receive continuous payments from PFES, meaning that PFES has not become a stable source of income, rendering the permanence of PFES limited. Improving monitoring and evaluation policies coupled with transparent, inclusive, independent mechanisms are essential to providing a more accurate reflection of impacts from PFES in Vietnam

TETRAOXYGENATED XANTHONES FROM THE LATEX OF GARCINIA COWA

Seven tetraoxygenated xanthones, namely fuscaxanthone A,7-O-methylgarcinone E, cowagarcinone A, cowaxanthone, rubraxanthone, cowanin and cowanol, were isolated from the dichloromethane extract of the latex of Garcinia cowa_Roxb. ex Choisy. Their structures were elucidated on the basis of 1D, 2D NMR spectroscopic data and comparison with reported data

SYNTHESIS AND CYTOTOXICITY OF POLYHYDROXYLATED CHOLESTEROL DERIVATIVES

Eight polyhydroxylated cholesterol derivatives (1-8) were prepared from cholesterol, using oxidative reagents as SeO2, OsO4/NMO, HCOOH/H2O2 and BH3/ H2O2. Their structures were elucidated by using physical methods including NMR 1D and 2D. These compounds were evaluated against two cancer cell lines (Hep-G2, T98). Compounds 2, 4 and 8 inhibits human hepatocellular carcinoma cell line (Hep-G2) with IC50 4.69, 4.98 and 2.89 µg/mL, respectively. In addition, compound 8 exhibited strong cytotoxicity against T98 cell line (glioblastoma) with IC50 = 2.28 μM

Preparation of self-assembly silica redox nanoparticles to improve drug encapsulation and suppress the adverse effect of doxorubicin

Background and Purpose: The utilization of doxorubicin (DOX) in clinal trials is also challenging owing to its adverse effects, including low oral bioavailability, generation of reactive oxygen species (ROS), cardiotoxicity, and epithelial barrier damage. Recently, scavenging of ROS reduced the cytotoxicity of DOX, suggesting a new approach for using DOX as an anticancer treatment. Thus, in this study, non-silica and silica redox nanoparticles (denoted as RNPN and siRNP, respectively) with ROS scavenging features have been designed to encapsulate DOX and reduce its cytotoxicity. Experimental Approach: DOX-loaded RNPN (DOX@RNPN) and DOX-loaded siRNP (DOX@siRNP) were prepared by co-dissolving DOX with RNPN and siRNP, respectively. The size and stability of nanoparticles were characterized by the dynamic light scattering system. Additionally, encapsulation efficiency, loading capacity, and release profile of DOX@RNPN and DOX@siRNP were identified by measuring the absorbance of DOX. Finally, the cytotoxicity of DOX@RNPN and DOX@siRNP against normal murine fibroblast cells (L929), human hepatocellular carcinoma cells (HepG2), and human breast cancer cells (MCF-7) were also investigated. Key results: The obtained result showed that RNPN exhibited a pH-sensitive character while silanol moieties improved the stability of siRNP in physiological conditions. DOX@RNPN and DOX@siRNP were formed at several tens of nanometers in diameter with narrow distribution. Moreover, DOX@siRNP stabilized under different pH buffers, especially gastric pH, and improved encapsulation of DOX owing to the addition of silanol groups. DOX@RNPN and DOX@siRNP maintained anticancer activity of DOX against HepG2, and MCF-7 cells, while their cytotoxicity on L929 cells was significantly reduced compared to free DOX treatment. Conclusion: DOX@RNPN and DOX@siRNP could effectively suppress the adverse effect of DOX, suggesting the potential to become promising nanomedicines for cancer treatments

Retrieval of Aerosol Optical Depth Using Satellite Data Associated with Ground-based Observations over Urban and Rural Areas

Optičku je dubinu aerosola (AOD) moguće točno izračunati na temelju uzastopnih mjerenja izravnog i difuznog Sunčeva zračenja na tlu. Međutim, prostorna pokrivenost i frekvencija lokacije uzrokuju određena ograničenja. Stoga su satelitske snimke ispravan alat za dobivanje proizvoda optičke dubine aerosola s više prostornih informacija i obrazaca raspodjele aerosola. Daljinskim istraživanjima aerosola možemo bolje razumjeti najbolji pristup računanju optičke dubine aerosola u urbanim i ruralnim područjima i mogu se uočiti razlike zbog svojstava površinske reflektivnosti. Ovaj se članak bavi konceptima smanjenja kontrasta i pristupima tamnih meta koji se ispituju snimkama Landsata i opažanjima Sunčevog fotometra za povezivanje raspodjele optičke dubine aerosola iznad grada Taipeija u Tajvanu. Za područja sa svijetlim površinama kao što su gradovi navedeni se koncepti primjenjuju metodom koeficijenta disperzije zajedno sa Sunčevim fotometrom kako bi se u velikoj mjeri smanjile pogreške. Za razliku od toga, algoritam tamne mete s odnosom površinske refleksije između plavih (0,49 μm), crvenih (0,66 μm) i infracrvenih (2,1 μm) spektralnih pojaseva prikladan je za vlažno tlo i područja s vegetacijom. Računanje prostorne raspodjele optičke dubine aerosola uspoređuje se s proizvodima MODIS AOD-a i AERONET-a kako bi se provjerila točnost rezultata. RMSE je bio u rasponu od 0,2 do 0,4 i oko 50% podataka bilo je unutar granica očekivane pogreške (EE=± (0,05+0,15 AODsunphometer).Aerosol optical depth (AOD) can be retrieved accurately with sequential ground-based measurements of direct and diffuse solar radiance. However, spatial coverage and location frequency cause certain limitations. Hence, satellite image data are a proper tool for obtaining aerosol optical depth products with more spatial information and patterns of aerosol distribution. Currently, aerosol remote sensing may enhance our understanding of the optimal approach to AOD retrieval over urban and rural areas, and how it differs due to the characteristics of surface reflectivity. The article deals with the concepts of contrast reduction, and dark target approaches are examined using Landsat imaging and the observation of a sun photometer for integrating aerosol optical depth distribution over the city of Taipei in Taiwan. For areas with bright surfaces, such as urban areas, the above concepts were applied using the dispersion coefficient method with a sun photometer, in order to reduce errors considerably in the product. In contrast, a dark target algorithm with a relationship of surface reflectance between the blue (0.49 μm), red (0.66 μm), and infrared (2.1 μm) spectral bands is suitable for moist soils and vegetation areas. The retrieval of AOD spatial distribution is compared with MODIS AOD products and AERONET to verify the accuracy of the results. The RMSE ranged from 0.2 to 0.4, and about 50% of the data were within expected error margins (EE=± (0.05+0.15 AODsunphotometer)

A Multi-Center Randomised Controlled Trial of Gatifloxacin versus Azithromycin for the Treatment of Uncomplicated Typhoid Fever in Children and Adults in Vietnam

BACKGROUND: Drug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotics, including the older generation fluoroquinolones, ciprofloxacin and ofloxacin, are failing. OBJECTIVES: We performed a randomised controlled trial to compare the efficacy and safety of gatifloxacin (10 mg/kg/day) versus azithromycin (20 mg/kg/day) as a once daily oral dose for 7 days for the treatment of uncomplicated typhoid fever in children and adults in Vietnam. METHODS: An open-label multi-centre randomised trial with pre-specified per protocol analysis and intention to treat analysis was conducted. The primary outcome was fever clearance time, the secondary outcome was overall treatment failure (clinical or microbiological failure, development of typhoid fever-related complications, relapse or faecal carriage of S. typhi). PRINCIPAL FINDINGS: We enrolled 358 children and adults with suspected typhoid fever. There was no death in the study. 287 patients had blood culture confirmed typhoid fever, 145 patients received gatifloxacin and 142 patients received azithromycin. The median FCT was 106 hours in both treatment arms (95% Confidence Interval [CI]; 94-118 hours for gatifloxacin versus 88-112 hours for azithromycin), (logrank test p = 0.984, HR [95% CI] = 1.0 [0.80-1.26]). Overall treatment failure occurred in 13/145 (9%) patients in the gatifloxacin group and 13/140 (9.3%) patients in the azithromycin group, (logrank test p = 0.854, HR [95% CI] = 0.93 [0.43-2.0]). 96% (254/263) of the Salmonella enterica serovar Typhi isolates were resistant to nalidixic acid and 58% (153/263) were multidrug resistant. CONCLUSIONS: Both antibiotics showed an excellent efficacy and safety profile. Both gatifloxacin and azithromycin can be recommended for the treatment of typhoid fever particularly in regions with high rates of multidrug and nalidixic acid resistance. The cost of a 7-day treatment course of gatifloxacin is approximately one third of the cost of azithromycin in Vietnam. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN67946944

Awareness and preparedness of healthcare workers against the first wave of the COVID-19 pandemic: A cross-sectional survey across 57 countries.

BACKGROUND: Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This study aimed to describe the level of awareness and preparedness of hospital HCWs at the time of the first wave. METHODS: This multinational, multicenter, cross-sectional survey was conducted among hospital HCWs from February to May 2020. We used a hierarchical logistic regression multivariate analysis to adjust the influence of variables based on awareness and preparedness. We then used association rule mining to identify relationships between HCW confidence in handling suspected COVID-19 patients and prior COVID-19 case-management training. RESULTS: We surveyed 24,653 HCWs from 371 hospitals across 57 countries and received 17,302 responses from 70.2% HCWs overall. The median COVID-19 preparedness score was 11.0 (interquartile range [IQR] = 6.0-14.0) and the median awareness score was 29.6 (IQR = 26.6-32.6). HCWs at COVID-19 designated facilities with previous outbreak experience, or HCWs who were trained for dealing with the SARS-CoV-2 outbreak, had significantly higher levels of preparedness and awareness (p<0.001). Association rule mining suggests that nurses and doctors who had a 'great-extent-of-confidence' in handling suspected COVID-19 patients had participated in COVID-19 training courses. Male participants (mean difference = 0.34; 95% CI = 0.22, 0.46; p<0.001) and nurses (mean difference = 0.67; 95% CI = 0.53, 0.81; p<0.001) had higher preparedness scores compared to women participants and doctors. INTERPRETATION: There was an unsurprising high level of awareness and preparedness among HCWs who participated in COVID-19 training courses. However, disparity existed along the lines of gender and type of HCW. It is unknown whether the difference in COVID-19 preparedness that we detected early in the pandemic may have translated into disproportionate SARS-CoV-2 burden of disease by gender or HCW type