812 research outputs found
Pediatric endocrine society survey of diabetes practices in the United States: What is the current state?
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144633/1/pedi12677.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144633/2/pedi12677_am.pd
Classifying livestock production systems for targeting agricultural research and development in a rapidly changing world
A myriad of agricultural and livestock production systems co-exist in the developing countries. Agricultural research for development should therefore aim at delivering strategies that are well targeted to the heterogeneous landscapes and diverse biophysical and socioeconomic contexts the agricultural production system is operating in. To that end, in the recent past several approaches to spatially delineate landscapes with broadly similar production strategies, constraints and investment opportunities, have been applied. The mapped Seré and
Steinfeld livestock production classification, for example, has been widely used for the targeting of pro-poor livestock intervention within ILRI. In this paper we describe potential methodologies for the inclusion of crop-specificity and intensification in the existing Seré and
Steinfeld livestock systems classification. We also present some first broad-brush future
projections of these detailed crop-livestock production systems. A number of example applications are discussed and recommendations for future improvement and use are made.
While the production system classifications are especially useful for bio-physical applications such as livestock-environment interactions and feed assessments, the links with socioeconomic factors still need to be explored further. Also, it is only one of the necessary building blocks for better targeting of research and development efforts. We, however,believe that the proposed system classifications will be of use to a variety of agricultural and livestock scientists and development agents alike. In addition, they serve as practical
examples making the case for the use of spatial stratification when targeting agricultural research and development
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The nature of weather and climate impacts in the energy sector
The power sectorâs meteorological information needs are diverse and cover many different distinct applications and users. Recognising this diversity, it is important to understand the general nature of how weather and climate influence the energy sector and the implications they have for quantitative impact modelling. Using conceptual
examples and illustrations from recent research, this chapter argues that the traditional âtransfer functionâ approach that is common to many industrial applications of weather and climate scienceâwhereby weather can be directly mapped to an energy impactâis inadequate for many important power system applications (such as price forecasting and system operations and planning). The chapter concludes by arguing that a deeper understanding of how meteorological impacts in the energy sector are modelled is required
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family. The interaction of TRAIL with death receptor 4 (DR4) and DR5 can trigger apoptotic cell death. The aim of this study was to investigate the role of TRAIL signaling in neonatal hypoxia-ischemia (HI). Using a neonatal mouse model of HI, mRNA, and protein expression of TRAIL, DR5 and the TRAIL decoy receptors osteoprotegerin (OPG), mDcTRAILR1, and mDcTRAILR2 were determined. In vitro, mRNA expression of these genes was measured in primary neurons and oligodendrocyte progenitor cells (OPCs) after inflammatory cytokine (TNF-α/IFN-γ) treatment and/or oxygen and glucose deprivation (OGD). The toxicity of these various paradigms was also measured. The expression of TRAIL, DR5, OPG, and mDcTRAILR2 was significantly increased after HI. In vitro, inflammatory cytokines and OGD treatment significantly induced mRNAs for TRAIL, DR5, OPG, and mDcTRAILR2 in primary neurons and of TRAIL and OPG in OPCs. TRAIL protein was expressed primarily in microglia and astroglia, whereas DR5 co-localized with neurons and OPCs in vivo. OGD enhanced TNF-α/IFN-γ toxicity in both neuronal and OPC cultures. Recombinant TRAIL exerted toxicity alone or in combination with OGD and TNF-α/IFN-γ in primary neurons but not in OPC cultures. The marked increases in the expression of TRAIL and its receptors after cytokine exposure and OGD in primary neurons and OPCs were similar to those found in our animal model of neonatal HI. The toxicity of TRAIL in primary neurons suggests that TRAIL signaling participates in neonatal brain injury after inflammation and HI
Frictionless bead packs have macroscopic friction, but no dilatancy
The statement of the title is shown by numerical simulation of homogeneously
sheared packings of frictionless, nearly rigid beads in the quasistatic limit.
Results coincide for steady flows at constant shear rate γ in the
limit of small γ and static approaches, in which packings are equilibrated
under growing deviator stresses. The internal friction angle ϕ, equal to
5.76 0.22 degrees in simple shear, is independent on the average pressure
P in the rigid limit. It is shown to stem from the ability of stable
frictionless contact networks to form stress-induced anisotropic fabrics. No
enduring strain localization is observed. Dissipation at the macroscopic level
results from repeated network rearrangements, like the effective friction
of a frictionless slider on a bumpy surface. Solid fraction Φ remains
equal to the random close packing value ≃ 0.64 in slowly or statically
sheared systems. Fluctuations of stresses and volume are observed to regress in
the large system limit, and we conclude that the same friction law for simple
shear applies in the large psystem limit if normal stress or density is
externally controlled. Defining the inertia number as I = γ m/(aP),
with m the grain mass and a its diameter, both internal friction
coefficient ∗ = tan ϕ and volume 1/Φ increase as
powers of I in the quasistatic limit of vanishing I, in which all mechanical
properties are determined by contact network geometry. The microstructure of
the sheared material is characterized with a suitable parametrization of the
fabric tensor and measurements of connectivity and coordination numbers
associated with contacts and near neighbors.Comment: 19 pages. Additional technical details may be found in v
Internal states of model isotropic granular packings. III. Elastic properties
In this third and final paper of a series, elastic properties of numerically
simulated isotropic packings of spherical beads assembled by different
procedures and subjected to a varying confining pressure P are investigated. In
addition P, which determines the stiffness of contacts by Hertz's law, elastic
moduli are chiefly sensitive to the coordination number, the possible values of
which are not necessarily correlated with the density. Comparisons of numerical
and experimental results for glass beads in the 10kPa-10MPa range reveal
similar differences between dry samples compacted by vibrations and lubricated
packings. The greater stiffness of the latter, in spite of their lower density,
can hence be attributed to a larger coordination number. Voigt and Reuss bounds
bracket bulk modulus B accurately, but simple estimation schemes fail for shear
modulus G, especially in poorly coordinated configurations under low P.
Tenuous, fragile networks respond differently to changes in load direction, as
compared to load intensity. The shear modulus, in poorly coordinated packings,
tends to vary proportionally to the degree of force indeterminacy per unit
volume. The elastic range extends to small strain intervals, in agreement with
experimental observations. The origins of nonelastic response are discussed. We
conclude that elastic moduli provide access to mechanically important
information about coordination numbers, which escape direct measurement
techniques, and indicate further perspectives.Comment: Published in Physical Review E 25 page
Solid behavior of anisotropic rigid frictionless bead assemblies
We investigate the structure and mechanical behavior of assemblies of
frictionless, nearly rigid equal-sized beads, in the quasistatic limit, by
numerical simulation. Three different loading paths are explored: triaxial
compression, triaxial extension and simple shear. Generalizing recent results
[1], we show that the material, despite rather strong finite sample size
effects, is able to sustain a finite deviator stress in the macroscopic limit,
along all three paths, without dilatancy. The shape of the yield surface is
adequately described by a Lade-Duncan (rather than Mohr-Coulomb) criterion.
While scalar state variables keep the same values as in isotropic systems,
fabric and force anisotropies are each characterized by one parameter and are
in one-to-one correspondence with principal stress ratio along all three
loading paths.The anisotropy of the pair correlation function extends to a
distance between bead surfaces on the order of 10% of the diameter. The tensor
of elastic moduli is shown to possess a nearly singular, uniaxial structure
related to stress anisotropy. Possible stress-strain relations in monotonic
loading paths are also discussed
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