Quantitative magnetic resonance imaging (qMRI) in Axial Spondyloarthritis

Imaging, and particularly magnetic resonance imaging (MRI), plays a crucial role in the assessment of inflammation in rheumatic disease, and forms a core component of the diagnostic pathway in axial spondyloarthritis (axSpA). However, conventional imaging techniques are limited by image contrast being non-specific to inflammation and a reliance on subjective, qualitative reader interpretation. Quantitative MRI (qMRI) methods offer scope to address these limitations and improve our ability to accurately and precisely detect and characterise inflammation, potentially facilitating a more personalised approach to management. Here, we review qMRI methods and emerging quantitative imaging biomarkers (QIBs) for imaging inflammation in axSpA. We discuss the potential benefits as well as the practical considerations that must be addressed in the movement toward clinical translation of QIBs

The influence of the picture superiority effect on performance in the word and picture form of the Free and Cued Selective Reminding Test

Background: The Free and Cued Selective Reminding Test (FCSRT) is a delayed cued recall test that controls attention and cognitive processing to obtain a measure of episodic memory that is unconfounded by normal age-related changes in cognition. Performance in the FCSRT is sensitive to the early changes in episodic memory associated with Alzheimer’s disease (AD). There are two forms of the FCSRT: a ‘word’ form and a ‘picture’ form. This study aimed to examine whether the picture superiority effect (PSE), the phenomenon that recall of pictures is often greater than recall of words, would influence healthy adults’ performance in the word and picture form of the FCSRT and whether this effect would be equivalent in younger and older adults. Method: Eighty-two participants with no known cognitive impairments took part in the study. Using a between-subjects design, we tested for the effects of age (younger vs. older), FCSRT format (word vs. picture) and their interaction on free recall, total recall and sensitivity to cueing as measured by the FCSRT. Results: The results showed that in the participants overall, the PSE was present in free recall, total recall and sensitivity to cueing, with a higher mean performance in the picture form than in the word form of the test. When the age groups were analysed separately, the PSE was only significant in the older participants for free recall, total recall and sensitivity to cueing. This resulted in a significant interaction between age and test format in free recall. Conclusions: Participants overall performed significantly better in the picture form than in the word form of the FCSRT, therefore, those administering the test should be aware that performance in the two forms may not be directly comparable. If future research supports this observation then form-dependent cut-off scores may significantly improve the diagnostic accuracy of the FCSRT

Boldness predicts plasticity in flight responses to winds

Behavioural plasticity can allow populations to adjust to environmental change when genetic evolution is too slow to keep pace. However, its constraints are not well understood. Personality is known to shape individual behaviour, but its relationship to behavioural plasticity is unclear. We studied the relationship between boldness and behavioural plasticity in response to wind conditions in wandering albatrosses (Diomedea exulans). We fitted multivariate hidden Markov models to an 11-year GPS dataset collected from 294 birds to examine whether the probability of transitioning between behavioural states (rest, prey search and travel) varied in response to wind, boldness and their interaction. We found that movement decisions varied with boldness, with bolder birds showing preferences for travel, and shyer birds showing preferences for search. For females, these effects depended on wind speed. In strong winds, which are optimal for movement, females increased time spent in travel, while in weaker winds, shyer individuals showed a slight preference for search, while bolder individuals maintained preference for travel. Our findings suggest that individual variation in behavioural plasticity may limit the capacity of bolder females to adjust to variable conditions and highlight the important role of behavioural plasticity in population responses to climate change

On gambling research, social science, and the consequences of commercial gambling

Social, political, economic, geographic and cultural processes related to the significant growth of the gambling industries have, in recent years, been the subject of a growing body of research. This body of research has highlighted relationships between social class and gambling expenditure, as well as the design, marketing and location of gambling products and businesses. It has also demonstrated the regressive nature of much gambling revenue, illuminating the influence that large gambling businesses have had on government policy and on researchers, including research priorities, agendas, and outcomes. Recently, critics have contended that although such scholarship has produced important insights about the operations and effects of gambling businesses, it is ideologically motivated and lacks scientific rigour. This response explains some basic theoretical and disciplinary concepts that such critique misunderstands, and argues for the value of social, political economic, geographic and cultural perspectives to the broader, interdisciplinary field of gambling research

Reliability of the quality of upper extremity skills test for children with cerebral palsy aged 2 to 12 years

Background Persistent impairments resulting from childhood acquired brain injury (ABI) can impact performance of activities of daily living (ADL). Objective and reliable measures of ADL skills are required for treatment planning and research. Aim To evaluate test-retest reproducibility of the Assessment of Motor and Process Skills (AMPS) for children with ABI. Methods Twenty-eight children with ABI (mean age 11 years 7 months, SD 2 years 4 months; males = 11) were recruited. Two AMPS tasks were performed over two consecutive days, as per standardized AMPS procedures. Intraclass correlation coefficients (ICC; 2,1), standard error of measurement (SEM), smallest detectable difference (SDD), and 95% limits of agreement (Bland-Altman) were calculated. Results Test-retest reliability was fair to good for AMPS ADL motor (ICC 0.55) and ADL process (ICC 0.58) measures. The SEM was 0.36 and 0.34 logits for AMPS ADL motor and ADL process measures respectively. The SDD was 1.0 (motor) and 0.93 logits (process) measures. A learning effect was evident. Conclusion Test-retest reproducibility of the AMPS was fair to good for children with ABI, which is poorer than previously published data. Administration of the AMPS in an unfamiliar environment, fatigue, and the small time interval between testing sessions may have contributed to poorer results. The AMPS remains a useful measure of ADL, contributing to our understanding of task execution processes