19 research outputs found
Artificial gut-on-a-disc platform to evaluate PH sensitive coatings of oral drug delivery devices
Rapid testing of pH coatings of oral drug delivery (ODD) devices is often complex and time consuming. A lab-on-a-disc (LoD) platform was developed which enables detection of integrity of pH coatings for up to four different pHs. The platform was designed to perfuse ODD devices through different pH in a sequential manner, mimicking the pH variations in the gastrointestinal (GI) tract. The disintegration of pH coatings causes release of drugs, which in turn is used to monitor integrity of pH coatings. Combining âevent-triggeredâ flow control, based on dissolvable film with electrochemical detection, enables accelerated, real-time characterization of ODD devices