20 research outputs found
California Environmental Protection Agency
Comite (pages 2-6) 2. Dermal absorption of 14C-bensulfuron-methyl (pages 7-9) 3. Dermal absorption of captan (pages 10-16) 4. Dermal absorption of radiolabeled maneb in male rats (pages 17-18
Risk Assessment of Florists Exposed to Pesticide Residues through Handling of Flowers and Preparing Bouquets
Microsomal monooxygenases in diamondback moth larvae resistant to fenvalerate and piperonyl butoxide
The effect of the cytochrome P-450 system inducers on the development of drosophila melanogaster
Biomonitoring and whole body cotton dosimetry to estimate potential human dermal exposure to semivolatile chemicals
Aldrin epoxidation and dihydroisodrin hydroxylation as probes ofin vivo andin vitro oxidative metabolic capability of some caterpillars
A detailed urinary excretion time course study of captan and folpet biomarkers in workers for the estimation of dose, main route-of-entry and most appropriate sampling and analysis strategies
Captan and folpet are two fungicides largely used in agriculture, but biomonitoring data are mostly limited to measurements of captan metabolite concentrations in spot urine samples of workers, which complicate interpretation of results in terms of internal dose estimation, daily variations according to tasks performed, and most plausible routes of exposure. This study aimed at performing repeated biological measurements of exposure to captan and folpet in field workers (i) to better assess internal dose along with main routes-of-entry according to tasks and (ii) to establish most appropriate sampling and analysis strategies. The detailed urinary excretion time courses of specific and non-specific biomarkers of exposure to captan and folpet were established in tree farmers (n = 2) and grape growers (n = 3) over a typical workweek (seven consecutive days), including spraying and harvest activities. The impact of the expression of urinary measurements [excretion rate values adjusted or not for creatinine or cumulative amounts over given time periods (8, 12, and 24 h)] was evaluated. Absorbed doses and main routes-of-entry were then estimated from the 24-h cumulative urinary amounts through the use of a kinetic model. The time courses showed that exposure levels were higher during spraying than harvest activities. Model simulations also suggest a limited absorption in the studied workers and an exposure mostly through the dermal route. It further pointed out the advantage of expressing biomarker values in terms of body weight-adjusted amounts in repeated 24-h urine collections as compared to concentrations or excretion rates in spot samples, without the necessity for creatinine corrections