Director\u27s report of research in Kansas 2014

This report contains the title, author, and publication information for manuscripts published by station scientists

Director\u27s report of research in Kansas 2003

This report contains the title, author, and publication information for manuscripts published by station scientists. It also contains a list of the research projects that were active during that period and a financial statement for the fiscal year

Director\u27s report of research in Kansas 2012

This report contains the title, author, and publication information for manuscripts published by station scientists

Director\u27s report of research in Kansas 2013

This report contains the title, author, and publication information for manuscripts published by station scientists

Targeting RTK signaling pathways in cancer

The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of proliferation, differentiation and survival. The induction of these pathways depends on Receptor Tyrosine Kinases (RTKs) that are activated upon ligand binding. In cancer, constitutive and aberrant activations of components of those pathways result in increased proliferation, survival and metastasis. For instance, mutations affecting RTKs, Ras, B-Raf, PI3K and AKT are common in perpetuating the malignancy of several types of cancers and from different tissue origins. Therefore, these signaling pathways became prime targets for cancer therapy. This review aims to provide an overview about the most frequently encountered mutations, the pathogenesis that results from such mutations and the known therapeutic strategies developed to counteract their aberrant functions

Peroxisomal regulation of redox homeostasis and adipocyte metabolism

Peroxisomes are ubiquitous cellular organelles required for specific pathways of fatty acid oxidation and lipid synthesis, and until recently their functions in adipocytes have not been well appreciated. Importantly, peroxisomes host many oxygen-consumption reactions and play a major role in generation and detoxification of reactive oxygen species (ROS) and reactive nitrogen species (RNS), influencing whole cell redox status. Here, we review recent progress in peroxisomal functions in lipid metabolism as related to ROS/RNS metabolism and discuss the roles of peroxisomal redox homeostasis in adipogenesis and adipocyte metabolism. We provide a framework for understanding redox regulation of peroxisomal functions in adipocytes together with testable hypotheses for developing therapies for obesity and the related metabolic diseases