3,217 research outputs found
Operant conditioning of spinal reflexes: from basic science to clinical therapy
New appreciation of the adaptive capabilities of the nervous system, recent recognition that most spinal cord injuries are incomplete, and progress in enabling regeneration are generating growing interest in novel rehabilitation therapies. Here we review the 35-year evolution of one promising new approach, operant conditioning of spinal reflexes. This work began in the late 1970’s as basic science; its purpose was to develop and exploit a uniquely accessible model for studying the acquisition and maintenance of a simple behavior in the mammalian central nervous system (CNS). The model was developed first in monkeys and then in rats, mice, and humans. Studies with it showed that the ostensibly simple behavior (i.e., a larger or smaller reflex) rests on a complex hierarchy of brain and spinal cord plasticity; and current investigations are delineating this plasticity and its interactions with the plasticity that supports other behaviors. In the last decade, the possible therapeutic uses of reflex conditioning have come under study, first in rats and then in humans. The initial results are very exciting, and they are spurring further studies. At the same time, the original basic science purpose and the new clinical purpose are enabling and illuminating each other in unexpected ways. The long course and current state of this work illustrate the practical importance of basic research and the valuable synergy that can develop between basic science questions and clinical needs
A Search for Additional Bodies in the GJ 1132 Planetary System from 21 Ground-based Transits and a 100 Hour Spitzer Campaign
We present the results of a search for additional bodies in the GJ 1132
system through two methods: photometric transits and transit timing variations
of the known planet. We collected 21 transit observations of GJ 1132b with the
MEarth-South array since 2015. We obtained 100 near-continuous hours of
observations with the Space Telescope, including two transits of GJ
1132b and spanning 60\% of the orbital phase of the maximum period at which
bodies coplanar with GJ 1132b would pass in front of the star. We exclude
transits of additional Mars-sized bodies, such as a second planet or a moon,
with a confidence of 99.7\%. When we combine the mass estimate of the star
(obtained from its parallax and apparent band magnitude) with the stellar
density inferred from our high-cadence light curve (assuming zero
eccentricity), we measure the stellar radius of GJ 1132 to be
, and we refine the radius measurement of
GJ 1132b to . Combined with HARPS RV measurements, we
determine the density of GJ 1132b to be \ g cm, with the
mass determination dominating this uncertainty. We refine the ephemeris of the
system and find no evidence for transit timing variations, which would be
expected if there was a second planet near an orbital resonance with GJ 1132b.Comment: 29 pages, 4 Tables, 8 Figures, Submitted to ApJ. Comments welcom
The rotation and Galactic kinematics of mid M dwarfs in the Solar Neighborhood
Rotation is a directly-observable stellar property, and drives magnetic field
generation and activity through a magnetic dynamo. Main sequence stars with
masses below approximately 0.35Msun (mid-to-late M dwarfs) are
fully-convective, and are expected to have a different type of dynamo mechanism
than solar-type stars. Measurements of their rotation rates provide insights
into these mechanisms, but few rotation periods are available for these stars
at field ages. Using photometry from the MEarth transit survey, we measure
rotation periods for 387 nearby, mid-to-late M dwarfs in the Northern
hemisphere, finding periods from 0.1 to 140 days. The typical detected rotator
has stable, sinusoidal photometric modulations at a semi-amplitude of 0.5 to
1%. We find no period-amplitude relation for stars below 0.25Msun and an
anti-correlation between period and amplitude for higher-mass M dwarfs. We
highlight the existence of older, slowly-rotating stars without H{\alpha}
emission that nevertheless have strong photometric variability. The Galactic
kinematics of our sample is consistent with the local population of G and K
dwarfs, and rotators have metallicities characteristic of the Solar
Neighborhood. We use the W space velocities and established age-velocity
relations to estimate that stars with P<10 days are on average <2 Gyrs, and
that those with P>70 days are about 5 Gyrs. The period distribution is mass
dependent: as the mass decreases, the slowest rotators at a given mass have
longer periods, and the fastest rotators have shorter periods. We find a lack
of stars with intermediate rotation periods. [Abridged]Comment: Accepted to ApJ. Machine readable tables and additional figures are
available in the published article or on reques
The Influence of Land Use and Climate Change on Forest Biomass and Composition in Massachusetts, USA
Land use and climate change have complex and interacting effects on naturally dynamic forest landscapes. To anticipate and adapt to these changes, it is necessary to understand their individual and aggregate impacts on forest growth and composition. We conducted a simulation experiment to evaluate regional forest change in Massachusetts, USA over the next 50 years (2010–2060). Our objective was to estimate, assuming a linear continuation of recent trends, the relative and interactive influence of continued growth and succession, climate change, forest conversion to developed uses, and timber harvest on live aboveground biomass (AGB) and tree species composition. We examined 20 years of land use records in relation to social and biophysical explanatory variables and used regression trees to create “probability-of-conversion” and “probability-of-harvest” zones. We incorporated this information into a spatially interactive forest landscape simulator to examine forest dynamics as they were affected by land use and climate change. We conducted simulations in a full-factorial design and found that continued forest growth and succession had the largest effect on AGB, increasing stores from 181.83 Tg to 309.56 Tg over 50 years. The increase varied from 49% to 112% depending on the ecoregion within the state. Compared to simulations with no climate or land use, forest conversion reduced gains in AGB by 23.18 Tg (or 18%) over 50 years. Timber harvests reduced gains in AGB by 5.23 Tg (4%). Climate change (temperature and precipitation) increased gains in AGB by 17.3 Tg (13.5%). Pinus strobus and Acer rubrum were ranked first and second, respectively, in terms of total AGB throughout all simulations. Climate change reinforced the dominance of those two species. Timber harvest reduced Quercus rubra from 10.8% to 9.4% of total AGB, but otherwise had little effect on composition. Forest conversion was generally indiscriminate in terms of species removal. Under the naïve assumption that future land use patterns will resemble the recent past, we conclude that continued forest growth and recovery will be the dominant mechanism driving forest dynamics over the next 50 years, and that while climate change may enhance growth rates, this will be more than offset by land use, primarily forest conversion to developed uses
Implementing Effective Tiered Interventions in Secondary Schools: Survey of school and support staff
An online survey and a series of interviews were focused on students in Years 7 to 9 who lack the foundational literacy and numeracy skills that are required to engage with a secondary curriculum, in schools where most students have these skills. These students are referred to throughout this report as struggling students. The students in scope are likely to struggle to engage in classes without significant differentiation on the part of classroom teachers, and the skill disparity may be so great that differentiating lessons for them is not feasible. The project sought to address 4 questions: What methods and/or assessments do schools use to identify students in this cohort? What frameworks do schools use to make decisions on how to support these students? What supports are provided? What confidence do school leaders and teachers have in the approaches currently used? This report provides an overview of the survey development, administration, and respondent demographics, and looks at the results of the survey for literacy and for numeracy. Additional detail and context provided by interview responses is included in the appropriate sections that discuss survey responses
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Four Centuries of Change in Northeastern United States Forests
The northeastern United States is a predominately-forested region that, like most of the eastern U.S., has undergone a 400-year history of intense logging, land clearance for agriculture, and natural reforestation. This setting affords the opportunity to address a major ecological question: How similar are today's forests to those existing prior to European colonization? Working throughout a nine-state region spanning Maine to Pennsylvania, we assembled a comprehensive database of archival land-survey records describing the forests at the time of European colonization. We compared these records to modern forest inventory data and described: (1) the magnitude and attributes of forest compositional change, (2) the geography of change, and (3) the relationships between change and environmental factors and historical land use. We found that with few exceptions, notably the American chestnut, the same taxa that made up the pre-colonial forest still comprise the forest today, despite ample opportunities for species invasion and loss. Nonetheless, there have been dramatic shifts in the relative abundance of forest taxa. The magnitude of change is spatially clustered at local scales (<125 km) but exhibits little evidence of regional-scale gradients. Compositional change is most strongly associated with the historical extent of agricultural clearing. Throughout the region, there has been a broad ecological shift away from late successional taxa, such as beech and hemlock, in favor of early- and mid-successional taxa, such as red maple and poplar. Additionally, the modern forest composition is more homogeneous and less coupled to local climatic controls
Co-designed Land-use Scenarios and their Implications for Storm Runoff and Streamflow in New England
Landscape and climate changes have the potential to create or exacerbate problems with stormwater management, high flows, and flooding. In New England, four plausible land-use scenarios were co-developed with stakeholders to give insight to the effects on ecosystem services of different trajectories of socio-economic connectedness and natural resource innovation. With respect to water, the service of greatest interest to New England stakeholders is the reduction of stormwater and flooding. To assess the effects of these land-use scenarios, we applied the Soil and Water Assessment Tool to two watersheds under two climates. Differences in land use had minimal effects on the water balance but did affect high flows and the contribution of storm runoff to streamflow. For most scenarios, the effect on high flows was small. For one scenario—envisioned to have global socio-economic connectedness and low levels of natural resource innovation—growth in impervious areas increased the annual maximum daily flow by 10%, similar to the 5–15% increase attributable to climate change. Under modest population growth, land-use decisions have little effect on storm runoff and high flows; however, for the two scenarios characterized by global socio-economic connectedness, differences in choices regarding land use and impervious area have a large impact on the potential for flooding. Results also indicate a potential interaction between climate and land use with a shift to more high flows resulting from heavy rains than from snowmelt. These results can help inform land use and development, especially when combined with assessments of effects on other ecosystem services
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