Design and Performance Assessment of Continuous Crystallization Processes Resolving Racemic Conglomerates

Continuous crystallization processes achieving the complete resolution of racemic feed mixtures of conglomerate forming substances are presented. The processes considered rely on the principles of preferential crystallization or attrition-enhanced deracemization (Viedma ripening). A single mechanistic population balance model is shown to describe both operating modes. For the case of isothermal Viedma ripening, a shortcut method is introduced that allows the rapid and computationally efficient design of processes using a single or multiple ripening stages. The achievable productivity and enantiomeric purity are determined for all process variants in a wide range of operating conditions, and Pareto optimal operating points are identified. Since our results are obtained with a consistent set of kinetics for all operating modes, an unbiased comparison is enabled. It is shown that the productivity of the ripening process can be improved by using cascades of multiple crystallizers, but that the preferential crystallization process still achieves higher productivity at full enantiomeric purity

The Basel Face Database: A validated set of photographs reflecting systematic differences in Big Two and Big Five personality dimensions - Fig 4

<p>An original face (middle) and versions with a reduced (left) and an enhanced value (right) on agency (top) and communion (bottom).</p

Visualization of the process to generate variations of an exemplar face on a specific personality dimension (here: Agreeableness).

<p>First, the face on the standardized and aligned photograph is reconstructed by fitting the Basel Face Model [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0193190#pone.0193190.ref026" target="_blank">26</a>] to the face on the photograph. Second, the resulting 3D reconstruction of the face is manipulated on a specific personality dimension. Finally, the altered faces are rendered back into the 2D photograph, resulting in natural-looking images that vary regarding their value on the respective personality dimension.</p

Additional file 1: of Perceptions about the relative importance of patient care-related topics: a single institutional survey of its anesthesiologists, nurse anesthetists, and surgeons

Perioperative Risk Optimization and Management Planning Tool (PROMPT™) Qualitative Clinician Survey. (PDF 65 kb

Means (and 95% CIs) for personality judgments collapsed over all 40 database faces with reduced, original, and enhanced values on agency and communion.

<p>Means (and 95% CIs) for personality judgments collapsed over all 40 database faces with reduced, original, and enhanced values on agency and communion.</p

Means and standard deviations of the Big Two judgments for the 40 facial identities with reduced, original, and enhanced values on both Big Two personality dimensions.

<p>Please note that the neutral versions (-/+) in the Agency and the Communion columns refer to the exact same stimuli.</p

The Basel Face Database: A validated set of photographs reflecting systematic differences in Big Two and Big Five personality dimensions - Fig 6

<p>An original face (middle) and versions with reduced (left) and enhanced values (right) on both Big Five personality dimensions (from top to bottom: openness, conscientiousness, extraversion, agreeableness, neuroticism).</p

Additional file 2: of Perceptions about the relative importance of patient care-related topics: a single institutional survey of its anesthesiologists, nurse anesthetists, and surgeons

Perioperative Risk Optimization and Management Planning Tool (PROMPT™) Quantitative Clinician Survey. (PDF 73 kb

The Basel Face Database: A validated set of photographs reflecting systematic differences in Big Two and Big Five personality dimensions - Fig 2

<p>The RAW image (left) was edited so that the background color was standardized, the axis between the eyes was centered, and the face size was fixed by aligning the chin and hairline (right).</p

Means and standard deviations of the Big Five judgments for the 40 facial identities with reduced, original, and enhanced values on all Big Five personality dimensions.

<p>Please note that the neutral versions (-/+) of all five personality dimensions refer to the exact same stimuli.</p