Профессору И. В. Гончарову - 65 лет

3 января 2012 г. исполнилось 65 лет со дня рождения профессора, доктора геолого-минералогических наук, профессора кафедры геологии и разведки полезных ископаемых Института природных ресурсов ТПУ Ивана Васильевича Гончарова

Nucleon-Nucleon Scattering in a Harmonic Potential

The discrete energy-eigenvalues of two nucleons interacting with a finite-range nuclear force and confined to a harmonic potential are used to numerically reconstruct the free-space scattering phase shifts. The extracted phase shifts are compared to those obtained from the exact continuum scattering solution and agree within the uncertainties of the calculations. Our results suggest that it might be possible to determine the amplitudes for the scattering of complex systems, such as n-d, n-t or n-alpha, from the energy-eigenvalues confined to finite volumes using ab-initio bound-state techniques.Comment: 19 pages, 13 figure

Preparation and characterization of low concentrated suspensions of industrial nanoparticles

В настоящее время одним из наиболее первпективных и развивающихся методов исследования размеров наночастиц является масс-спектрометрия с индуктивно связанной плазмой по методу единичных частиц (SP ICP-MS), позволяющая исседовать частицы в очень низких эколонически-эквивалентных концентарциях. В настоящей работе рассмотрены различные метдики приготовления суспензий промышленных наночастиц для исследования с помощью SP ICP-MS, выбраны оптимальные условия и представлены первые результаты

Особенности продвижения образовательных услуг ТПУ на китайском рынке

В статье рассмотрены особенности продвижения образовательных услуг ТПУ на китайском рынке, приведены доводы целесообразности выхода университета на международную арену, описаны способы, с помощью которых ТПУ предоставляет свои услуги. На базе данных характеристик проводится маркетинговое исследование информационной обеспеченности университета

Alcohol-induced decrease in muscle protein synthesis associated with increased binding of mTOR and raptor: Comparable effects in young and mature rats

<p>Abstract</p> <p>Background</p> <p>Acute alcohol (EtOH) intoxication decreases muscle protein synthesis via inhibition of mTOR-dependent translation initiation. However, these studies have been performed in relatively young rapidly growing rats in which muscle protein accretion is more sensitive to growth factor and nutrient stimulation. Furthermore, some in vivo-produced effects of EtOH vary in an age-dependent manner. The hypothesis tested in the present study was that young rats will show a more pronounced decrement in muscle protein synthesis than older mature rats in response to acute EtOH intoxication.</p> <p>Methods</p> <p>Male F344 rats were studied at approximately 3 (young) or 12 (mature) months of age. Young rats were injected intraperitoneally with 75 mmol/kg of EtOH, and mature rats injected with either 75 or 90 mmol/kg EtOH. Time-matched saline-injected control rats were included for both age groups. Gastrocnemius protein synthesis and the activity of the mTOR pathway were assessed 2.5 h after EtOH using [³H]-labeled phenylalanine and the phosphorylation of various protein factors known to regulate peptide-chain initiation.</p> <p>Results</p> <p>Blood alcohol levels (BALs) were lower in mature rats compared to young rats after administration of 75 mmol/kg EtOH (154 ± 23 vs 265 ± 24 mg/dL). However, injection of 90 mmol/kg EtOH in mature rats produced BALs comparable to that of young rats (281 ± 33 mg/dL). EtOH decreased muscle protein synthesis similarly in both young and high-dose EtOH-treated mature rats. The EtOH-induced changes in both groups were associated with a concomitant reduction in 4E-BP1 phosphorylation, and redistribution of eIF4E between the active eIF4E·eIF4G and inactive eIF4E·4EBP1 complex. Moreover, EtOH increased the binding of mTOR with raptor in a manner which appeared to be AMPK- and TSC-independent. In contrast, although muscle protein synthesis was unchanged in mature rats given low-dose EtOH, compared to control values, the phosphorylation of rpS6 and eIF4G was decreased.</p> <p>Conclusion</p> <p>These data indicate that muscle protein synthesis is equally sensitive to the inhibitory effects of EtOH in young rapidly growing rats and older mature rats which are growing more slowly, but that mature rats must be given a relatively larger dose of EtOH to achieve the same BAL. Based on the differential response in mature rats to low- and high-dose EtOH, the decreased protein synthesis was associated with a reduction in mTOR activity which was selectively mediated via a reduction in 4E-BP1 phosphorylation and an increase in mTOR·raptor formation.</p