Title VII: An Overview of Some Common Employer Pitfalls

Titile VII of the Civil Rights Act of 1964 and other supporting acts and laws have established certain employment rights for the vast majority of employees throughout the United States, and the procedures for enforcing those rights. Substantial efforts have been made by federal and state agencies, as well as minority interest groups, to publicize the laws and their enforcement procedures. In 1974 it can be safely assumed that virtually all employees affected by the equal employment laws are familiar with their rights or, minim- ally, know where to obtain sufficient information to be fully apprised of those rights. Surprisingly, the corollary is not true. Employers often are woefully uninformed regarding permitted and prohibited employment practices. Often, employment relations are a minor or even insignificant facet of the general operation of a business. Problems rarely occur as a result of an overt desire to violate the equal em- ployment laws or the rights of any employees. On the contrary, management\u27s policies and practices are most often genuinely motivated by a desire to maintain or improve the conduct of business. However, decisions implemented without sufficient knowledge of or concern for protected employee rights can prove to be disastrous, as will be discussed later in this article

New York State Disability and Employment Status Report, 2009.

This Status Report is intended to provide information on disability in New York State, focusing on the working-age population (16-64 years old, except where noted). The report presents: 1) estimates of disability prevalence overall and among various groups; 2) indications of where disparities exist in employment rate, educational attainment, and financial status between people with and without disabilities; and 3) characteristics of New York State which may influence employment outcomes for people with disabilities

Molekulare Kapseln und Protein - Rezeptoren auf Calixaren - Basis

Im Rahmen dieser Dissertation wurden molekulare Kapseln durch Selbstorganisation zweier ionischer Calix[4]arenhalbschalen in polarer Lösung hergestellt und mittels verschiedener Methoden wie NMR - Titration, Job, NOESY - Experimenten detailliert untersucht. Weiterhin wurden die kapseln durch ESI-MS genau charakterisiert. Zum erstenmal gelang uns die Bestimmung der relativen Stabilität der selbstorganisierten Kapseln in Lösung. Unsere Ergebnisse belegen eine relativ gute Übereinstimmung zwischen Bindungskonstanten aus der Lösung (NMR-Titration) und absoluten Peakintensitäten in den ESI-MS Spektren. Über MS/MS-Experimente gelang darüber hinaus die Bestimmung der Stabilität der molekularen Kapseln in der Gasphase. Wegen des amphiphilen Charakters des Calix[4]arentetraphosphonats wurde es in eine Stearinsäure - Monoschicht an der Luft/Wasser-Grenzfläche eingelagert. Dadurch wurde ein biomimetisches Membrane - Modell mit darin befindlichen mobilem Rezeptoren aufgebaut. Mit Hilfe dessen können Proteine je nach IEP in bis zu nanomolaren Konzentrationen in Wasser, Puffer - Lösung bzw. Salz - Lösung nachgewiesen werden

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation.

Molecular tweezers (MTs) are supramolecular host molecules equipped with two aromatic pincers linked together by a spacer (Gakh, 2018). They are endowed with fascinating properties originating from their ability to hold guests between their aromatic pincers (Chen and Whitlock, 1978; Zimmerman, 1991; Harmata, 2004). MTs are finding an increasing number of medicinal applications, e.g., as bis-intercalators for DNA such as the anticancer drug Ditercalinium (Gao et al., 1991), drug activity reverters such as the bisglycoluril tweezers Calabadion 1 (Ma et al., 2012) as well as radioimmuno detectors such as Venus flytrap clusters (Paxton et al., 1991). We recently embarked on a program to create water-soluble tweezers which selectively bind the side chains of lysine and arginine inside their cavity. This unique recognition mode is enabled by a torus-shaped, polycyclic framework, which is equipped with two hydrophilic phosphate groups. Cationic amino acid residues are bound by the synergistic effect of disperse, hydrophobic, and electrostatic interactions in a kinetically fast reversible process. Interactions of the same kind play a key role in numerous protein-protein interactions, as well as in pathologic protein aggregation. Therefore, these particular MTs show a high potential to disrupt such events, and indeed inhibit misfolding and self-assembly of amyloidogenic polypeptides without toxic side effects. The mini-review provides insight into the unique binding mode of MTs both toward peptides and aggregating proteins. It presents the synthesis of the lead compound CLR01 and its control, CLR03. Different biophysical experiments are explained which elucidate and help to better understand their mechanism of action. Specifically, we show how toxic aggregates of oligomeric and fibrillar protein species are dissolved and redirected to form amorphous, benign assemblies. Importantly, these new chemical tools are shown to be essentially non-toxic in vivo. Due to their reversible moderately tight binding, these agents are not protein-, but rather process-specific, which suggests a broad range of applications in protein misfolding events. Thus, MTs are highly promising candidates for disease-modifying therapy in early stages of neurodegenerative diseases. This is an outstanding example in the evolution of supramolecular concepts toward biological application

Virtual health care center in Georgia

Application of telemedicine systems to cover distant geographical areas has increased recently. However, the potential usefulness of similar systems for creation of national networks does not seem to be widely appreciated. The article describes the "Virtual Health Care Knowledge Center in Georgia" project. Its aim was the set up of an online integrated web-based platform to provide remote medical consultations and eLearning cycles. The project "Virtual Health Care Knowledge Center in Georgia" was the NATO Networking Infrastructure Grant dedicated for development of telemedicine in non-NATO countries. The project implemented a pilot to organize the creation of national eHealth network in Georgia and to promote the use of innovative telemedicine and eLearning services in the Georgian healthcare system. In June 2007 it was continued under the NATO Networking Infrastructure Grant "ePathology – Virtual Pathology Center in Georgia as the Continuation of Virtual Health Care Center"

Foundations in Wisconsin: A Directory [23rd ed. 2004]

This 2004 edition of Foundations in Wisconsin marks the 23rd release of the print directory and the 4th year of the online version. The directory is designed as a research tool for grantseekers interested in locating information on private, corporate, and community foundations registered in Wisconsin. Each entry in this new edition has been updated or reviewed to provide the most current information available. Most of the data was extracted from IRS 990-PF tax returns filed by the foundations. However, additional information was obtained from surveys, annual reports, and foundation Web sites. Wisconsin foundations have shown small increases as compared to the 2003 edition. The number of active foundations has grown to an all-time high of 1184. Both total assets and grants for the state’s foundations increased from 2003, albeit not to the heights documented in the 2002 edition. Total assets grew by 1.53% and total grants by .23%. The following table details the financial pattern over the 10 years.https://epublications.marquette.edu/lib_fiw/1007/thumbnail.jp

Starre biomimetische Adrenalinrezeptor-Modelle

Im Rahmen dieser Arbeit wurden starre biomimetische Rezeptoren auf Bisphosphonat-Basis für Catecholamine, die eine wichtige Klasse von Hormonen und Neurotransmittern darstellen, entwickelt und synthetisiert. Diese makrozyklischen oder pinzettenförmigen Wirtverbindungen wurden durch 1H-NMR-Titrationen auf ihre Bindungseigenschaften in polarer Lösung untersucht. Desweiteren wurden die amphiphilen Rezeptoren in eine Lipidmonoschicht an der Luft/Wasser-Grenzschicht eingelagert und zeigten auch in diesem einfachen Membranmodell starke und selektive Bindung von Adrenalinderivaten

Mobile education in autopsy conferences of pathology: presentation of complex cases

BACKGROUND: MeduMobile was a project to develop and evaluate learning scenarios for medical students and teachers by use of video communication and notebooks. Its core part was assigned to various medical routines, conferences or meetings such as doctor-patient bedside conversation. These were filmed by video teams and broadcasted live via the WLAN of the Charité campus to course participating students. One type of the learning arrangements was the autopsy conference as an on-call scenario. MATERIALS AND METHODS: The MeduMobile project consisted of two main compartments: the regular seminar event which took place every week or month, and the on-call event. For an on-call event the students were informed two hours before the lesson's start. A mobile video team organised the video conference via a specific MeduMobile seminar system. This software offered the students to log. The MeduMobile seminar system is based on the Windows operating system and realises an extended video communication via WLAN. Thirteen access points were implemented at the Charité Campus Virchow Klinikum and Campus Mitte. A questionnaire was developed to investigate in the response and learning effect of the mobile seminar system. RESULTS: During the MeduMobile project 42 video conferences with (cumulative) 145 participating students took place. Four autopsy conferences could be organised as on-call scenarios within this project. A prospective, not randomised follow-up study was included 25 students of the 1(st )– 6(th )clinical semester. According to the answers, professional reasoning, professional performance, sustainability, and the complexity were broadly accepted by the students. DISCUSSION: In principle, the MeduMobile realised an interdisciplinary case presentation using video conference and web page. The evaluation indicates a high acception of such complex case presentation with multidisciplinary settings. The use of the notebooks in mobile learning enables an interconnective training and promotes a complex learning

Wasserlösliche molekulare Klammern und Pinzetten zur Komplexierung von biorelevanten Molekülen

Wasserlösliche molekulare Klammern und Pinzetten zur Komplexierung von biorelevanten Molekülen. Die Synthese und die Eigenschaften von neuartigen molekularen Klammern und Pinzetten werden beschrieben. Aufgrund ihrer Struktur und elektronischen Eigenschaften können diese elektronenarme Verbindungen in ihre elektronenreiche Kavität einschließen. Die hier vorgestellte molekulare Klammer auf Bisphosphonat-Basis bietet erstmalig die Möglichkeit wichtige Co-Faktoren wie NAD+ und Thiaminpyrophosphat in wässriger Lösung zu komplexieren. Die ebenfalls vorgestellte molekulare Pinzette auf Bisphosphonat-Basis gehört zu den besten künstlichen Rezeptoren für die Aminosäure Lysin die momentan bekannt sind. Das Bindungsverhalten beider Moleküle wird mit verschiedenen Methoden, wie z.B. NMR-Titrationen, Isothermaler Titrationskalorimetrie, Langmuir-Blodgett Experimenten und Molecular Modelling untersucht und beschrieben

Dendrimere Bisphosphonatrezeptoren zur molekularen Erkennung von basischen Proteinoberflächen

Im Rahmen dieser Arbeit wurde aus der, bereits aus den Arbeiten von Schrader et al. bekannten Bisphosphonatpinzette, die eine selektive Erkennungseinheit für die basischen Aminosäuren Arginin und Lysin in nicht-wäßrigen Lösungen darstellt, ein multivalenter Rezeptor auf Dendrimerbasis entwickelt. Dieser wurde mit verschiedenen spektroskopische Methoden wie PFG-NMR, UV/Vis-Titration und Fluoreszenzmessungen auf seine Affinität zu Proteinoberflächen in wäßriger, gepufferter Lösung untersucht, die eine große Anzahl basischer Aminosäuren präsentieren (z.B. Cytochrom c, BSA)