525 research outputs found

    The Effects of Gender and Self Construal on Perception of Racism

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    When looking into the idea of if one\u27s gender and their self-construal has an effect on how they perceive racism, we hypothesize that women will take a more interdependent self-construal and men will take a more independent self-construal. Based on how they identify, we believe that those in the interdependent condition will perceive more racism and those in the independent condition will perceive less racism

    Genome signature analysis of thermal virus metagenomes reveals Archaea and thermophilic signatures

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    <p>Abstract</p> <p>Background</p> <p>Metagenomic analysis provides a rich source of biological information for otherwise intractable viral communities. However, study of viral metagenomes has been hampered by its nearly complete reliance on BLAST algorithms for identification of DNA sequences. We sought to develop algorithms for examination of viral metagenomes to identify the origin of sequences independent of BLAST algorithms. We chose viral metagenomes obtained from two hot springs, Bear Paw and Octopus, in Yellowstone National Park, as they represent simple microbial populations where comparatively large contigs were obtained. Thermal spring metagenomes have high proportions of sequences without significant Genbank homology, which has hampered identification of viruses and their linkage with hosts. To analyze each metagenome, we developed a method to classify DNA fragments using genome signature-based phylogenetic classification (GSPC), where metagenomic fragments are compared to a database of oligonucleotide signatures for all previously sequenced Bacteria, Archaea, and viruses.</p> <p>Results</p> <p>From both Bear Paw and Octopus hot springs, each assembled contig had more similarity to other metagenome contigs than to any sequenced microbial genome based on GSPC analysis, suggesting a genome signature common to each of these extreme environments. While viral metagenomes from Bear Paw and Octopus share some similarity, the genome signatures from each locale are largely unique. GSPC using a microbial database predicts most of the Octopus metagenome has archaeal signatures, while bacterial signatures predominate in Bear Paw; a finding consistent with those of Genbank BLAST. When using a viral database, the majority of the Octopus metagenome is predicted to belong to archaeal virus Families <it>Globuloviridae </it>and <it>Fuselloviridae</it>, while none of the Bear Paw metagenome is predicted to belong to archaeal viruses. As expected, when microbial and viral databases are combined, each of the Octopus and Bear Paw metagenomic contigs are predicted to belong to viruses rather than to any Bacteria or Archaea, consistent with the apparent viral origin of both metagenomes.</p> <p>Conclusion</p> <p>That BLAST searches identify no significant homologs for most metagenome contigs, while GSPC suggests their origin as archaeal viruses or bacteriophages, indicates GSPC provides a complementary approach in viral metagenomic analysis.</p

    Knowledge of hepatitis C screening and management by internal medicine residents: trends over 2 years

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    Over 2 million people in the United States are infected with hepatitis C, and there has been an explosion in knowledge regarding this disease in the last decade. Internal medicine residents must be able to identify patients at risk for hepatitis C and institute appropriate diagnostic testing and referral of these patients. Methods : A survey regarding hepatitis C risk factors and the management of hepatitis C patients was administered on three occasions over 15 months (time 0, 1 month, and 15 months) to members of a large university-based internal medicine residency. Results : During the study period 59 residents completed all three surveys. Less than half of the residents (39%) ask patients about hepatitis C risk factors. Only 58% reported that they would refer a hepatitis C antibody positive patient with elevated liver enzymes to a subspecialist on the initial survey. The residents who did not refer patients cited low response rates, high side-effect profiles, and the high cost of therapy as reasons for not referring the patient. There was significant improvement (58% vs 78%, p < 0.01 ) in the rate of patient referral during the 15-month study period but no substantial improvement in the other knowledge deficits. Conclusions : The knowledge base of the internal medicine residents about hepatitis C screening and management is suboptimal. New, more effective hepatitis C education programs for internal medicine residents should be initiated.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75407/1/j.1572-0241.2002.05708.x.pd

    Substantia nigra activity level predicts trial-to-trial adjustments in cognitive control

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    Effective adaptation to the demands of a changing environment requires flexible cognitive control. The medial and the lateral frontal cortices are involved in such control processes, putatively in close interplay with the BG. In particular, dopaminergic projections from the midbrain (i.e., from the substantia nigra [SN] and the ventral tegmental area) have been proposed to play a pivotal role in modulating the activity in these areas for cognitive control purposes. In that dopaminergic involvement has been strongly implicated in reinforcement learning, these ideas suggest functional links between reinforcement learning, where the outcome of actions shapes behavior over time, and cognitive control in a more general context, where no direct reward is involved. Here, we provide evidence from functional MRI in humans that activity in the SN predicts systematic subsequent trial-to-trial RT prolongations that are thought to reflect cognitive control in a stop-signal paradigm. In particular, variations in the activity level of the SN in one trial predicted the degree of RT prolongation on the subsequent trial, consistent with a modulating output signal from the SN being involved in enhancing cognitive control. This link between SN activity and subsequent behavioral adjustments lends support to theoretical accounts that propose dopaminergic control signals that shape behavior both in the presence and in the absence of direct reward. This SN-based modulatory mechanism is presumably mediated via a wider network that determines response speed in this task, including frontal and parietal control regions, along with the BG and the associated subthalamic nucleus

    Data Ownership—A Property Rights Approach from a European Perspective

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    Data has become one of the most important resources in post-modern information society. However, European civil law does not reflect this development adequately. In fact, so far, European civil law seems to struggle with handling data as a legal entity. Against this background, the article provides a transnational overview and a comprehensive analysis of the legal situation in Europe. It discusses why data ownership is widely perceived as a problem on this side of the Atlantic and how this perception can be overcome by a fundamental property law approach. Taking into account economic realities, we argue that European property law provides a sufficient framework for establishing a theoretical concept of data ownership. Therefore, we draft the dimensions of a data ownership concept by proposing potential criteria for assigning ownership and analyzing both positive access and negative restriction rights

    Symbolic Manipulators Affect Mathematical Mindsets

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    Symbolic calculators like Mathematica are becoming more commonplace among upper level physics students. The presence of such a powerful calculator can couple strongly to the type of mathematical reasoning students employ. It does not merely offer a convenient way to perform the computations students would have otherwise wanted to do by hand. This paper presents examples from the work of upper level physics majors where Mathematica plays an active role in focusing and sustaining their thought around calculation. These students still engage in powerful mathematical reasoning while they calculate but struggle because of the narrowed breadth of their thinking. Their reasoning is drawn into local attractors where they look to calculation schemes to resolve questions instead of, for example, mapping the mathematics to the physical system at hand. We model the influence of Mathematica as an integral part of the constant feedback that occurs in how students frame, and hence focus, their work

    Performance of an Annular Linear Induction Pump with Applications to Space Nuclear Power Systems

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    Results of performance testing of an annular linear induction pump are presented. The pump electromagnetically pumps liquid metal through a circuit specially designed to allow for quantification of the performance. Testing was conducted over a range of conditions, including frequencies of 33, 36, 39, and 60 Hz, liquid metal temperatures from 125 to 525 C, and input voltages from 5 to 120 V. Pump performance spanned a range of flow rates from roughly 0.16 to 5.7 L/s (2.5 to 90 gpm), and pressure head less than 1 to 90 kPa (less than 0.145 to 13 psi). The maximum efficiency measured during testing was slightly greater than 6%. The efficiency was fairly insensitive to input frequency from 33 to 39 Hz, and was markedly lower at 60 Hz. In addition, the efficiency decreased as the NaK temperature was raised. The performance of the pump operating on a variable frequency drive providing 60 Hz power compared favorably with the same pump operating on 60 Hz power drawn directly from the electrical grid

    Epistemic Complexity and the Journeyman-Expert Transition

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    Physics students can encounter difficulties in physics problem solving as a result of failing to use knowledge that they have but do not perceive as relevant or appropriate. In previous work the authors have demonstrated that some of these difficulties may be epistemological. Students may limit the kinds of knowledge that they use. For example, they may use formal manipulations and ignore physical sense making or vice versa. Both beginning (novice) and intermediate (journeymen) students demonstrate these difficulties. Learning both to switch one's epistemological lens on a problem and to integrate different kinds of knowledge is a critical component of learning to solve problems in physics effectively. In this paper, we present two case studies in which journeyman students (upper-division physics majors) demonstrate switching between epistemological resources in approaching a complex problem. We conjecture that mastering these epistemological skills is an essential component of learning complex problem solving in physics.Comment: 12 page

    Five Geneseo Monuments: Exhibition Catalog

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    SUNY Geneseo Museum Studies Class Exhibition, Fall 2019. Bridge Gallery, December 4, 2019. The Big Tree The Bear Fountain Monument: A Symbol of Community James Samuel Wadsworth Statue Progression Toward Modernity: Geneseo’s Suffragists, The Shaw Sisters The Geneseo Fire Department Memorialhttps://knightscholar.geneseo.edu/geneseo-authors/1009/thumbnail.jp

    The Drosophila DmGluRA is required for social interaction and memory

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    Metabotropic glutamate receptors (mGluRs) have well-established roles in cognition and social behavior in mammals. Whether or not these roles have been conserved throughout evolution from invertebrate species is less clear. Mammals have eight mGluRs whereas Drosophila has a single DmGluRA, which has both Gi and Gq coupled signaling activity. We have utilized Drosophila to examine the role of DmGluRA in social behavior and various phases of memory. We have found that flies that are homozygous or heterozygous for loss of function mutations of DmGluRA have impaired social behavior in male Drosophila. Futhermore, flies that are heterozygous for loss of function mutations of DmGluRA have impaired learning during training, immediate-recall memory, short-term memory, and long-term memory as young adults. This work demonstrates a role for mGluR activity in both social behavior and memory in Drosophila
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