341 research outputs found

    Coupled feedback loops maintain synaptic long-term potentiation: A computational model of PKMzeta synthesis and AMPA receptor trafficking

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    In long-term potentiation (LTP), one of the most studied types of neural plasticity, synaptic strength is persistently increased in response to stimulation. Although a number of different proteins have been implicated in the sub-cellular molecular processes underlying induction and maintenance of LTP, the precise mechanisms remain unknown. A particular challenge is to demonstrate that a proposed molecular mechanism can provide the level of stability needed to maintain memories for months or longer, in spite of the fact that many of the participating molecules have much shorter life spans. Here we present a computational model that combines simulations of several biochemical reactions that have been suggested in the LTP literature and show that the resulting system does exhibit the required stability. At the core of the model are two interlinked feedback loops of molecular reactions, one involving the atypical protein kinase PKM{\zeta} and its messenger RNA, the other involving PKM{\zeta} and GluA2-containing AMPA receptors. We demonstrate that robust bistability - stable equilibria both in the synapse's potentiated and unpotentiated states - can arise from a set of simple molecular reactions. The model is able to account for a wide range of empirical results, including induction and maintenance of late-phase LTP, cellular memory reconsolidation and the effects of different pharmaceutical interventions

    Outgroup Homogeneity Bias Causes Ingroup Favoritism

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    Ingroup favoritism, the tendency to favor ingroup over outgroup, is often explained as a product of intergroup conflict, or correlations between group tags and behavior. Such accounts assume that group membership is meaningful, whereas human data show that ingroup favoritism occurs even when it confers no advantage and groups are transparently arbitrary. Another possibility is that ingroup favoritism arises due to perceptual biases like outgroup homogeneity, the tendency for humans to have greater difficulty distinguishing outgroup members than ingroup ones. We present a prisoner's dilemma model, where individuals use Bayesian inference to learn how likely others are to cooperate, and then act rationally to maximize expected utility. We show that, when such individuals exhibit outgroup homogeneity bias, ingroup favoritism between arbitrary groups arises through direct reciprocity. However, this outcome may be mitigated by: (1) raising the benefits of cooperation, (2) increasing population diversity, and (3) imposing a more restrictive social structure.Comment: 7 pages, 9 figure
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