Segregation of Polymers in Confined Spaces

We investigate the motion of two overlapping polymers with self-avoidance confined in a narrow 2d box. A statistical model is constructed using blob free-energy arguments. We find spontaneous segregation under the condition: $L > R_{//}$, and mixing under $L < R_{//}$, where L is the length of the box, and $R_{//}$ the polymer extension in an infinite slit. Segregation time scales are determined by solving a mean first-passage time problem, and by performing Monte Carlo simulations. Predictions of the two methods show good agreement. Our results may elucidate a driving force for chromosomes segregation in bacteria

Strong pressure-energy correlations in van der Waals liquids

Strong correlations between equilibrium fluctuations of the configurational parts of pressure and energy are found in the Lennard-Jones liquid and other simple liquids, but not in hydrogen-bonding liquids like methanol and water. The correlations, that are present also in the crystal and glass phases, reflect an effective inverse power-law repulsive potential dominating fluctuations, even at zero and slightly negative pressure. In experimental data for supercritical Argon, the correlations are found to be approximately 96%. Consequences for viscous liquid dynamics are discussed.Comment: Phys. Rev. Lett., in pres

Critical Phenomena with Linked Cluster Expansions in a Finite Volume

Linked cluster expansions are generalized from an infinite to a finite volume. They are performed to 20th order in the expansion parameter to approach the critical region from the symmetric phase. A new criterion is proposed to distinguish 1st from 2nd order transitions within a finite size scaling analysis. The criterion applies also to other methods for investigating the phase structure such as Monte Carlo simulations. Our computational tools are illustrated at the example of scalar O(N) models with four and six-point couplings for $N=1$ and $N=4$ in three dimensions. It is shown how to localize the tricritical line in these models. We indicate some further applications of our methods to the electroweak transition as well as to models for superconductivity.Comment: 36 pages, latex2e, 7 eps figures included, uuencoded, gzipped and tarred tex file hdth9607.te

Multicanonical Ensemble: A New Approach to Simulate First-order Phase Transitions

Relying on the recently proposed multicanonical algorithm, we present a numerical simulation of the first order phase transition in the 2d 10-state Potts model on lattices up to sizes $100\times100$. It is demonstrated that the new algorithm $lacks$ an exponentially fast increase of the tunneling time between metastable states as a function of the linear size $L$ of the system. Instead, the tunneling time diverges approximately proportional to $L^{2.65}$. Thus the computational effort as counted per degree of freedom for generating an independent configuration in the unstable region of the model rises proportional to $V^{2.3}$, where $V$ is the volume of the system. On our largest lattice we gain more than two orders of magnitude as compared to a standard heat bath algorithm. As a first physical application we report a high precision computation of the interfacial tension

Numerical study of duality and universality in a frozen superconductor

The three-dimensional integer-valued lattice gauge theory, which is also known as a "frozen superconductor," can be obtained as a certain limit of the Ginzburg-Landau theory of superconductivity, and is believed to be in the same universality class. It is also exactly dual to the three-dimensional XY model. We use this duality to demonstrate the practicality of recently developed methods for studying topological defects, and investigate the critical behavior of the phase transition using numerical Monte Carlo simulations of both theories. On the gauge theory side, we concentrate on the vortex tension and the penetration depth, which map onto the correlation lengths of the order parameter and the Noether current in the XY model, respectively. We show how these quantities behave near the critical point, and that the penetration depth exhibits critical scaling only very close to the transition point. This may explain the failure of superconductor experiments to see the inverted XY model scaling.Comment: 17 pages, 18 figures. Updated to match the version published in PRB (http://link.aps.org/abstract/PRB/v67/e014525) on 27 Jan 200

Impact of the NK Cell Receptor LIR-1 (ILT-2/CD85j/LILRB1) on Cytotoxicity against Multiple Myeloma

The role of different receptors in natural-killer- (NK-) cell-mediated cytotoxicity against multiple myeloma (MM) cells is unknown. We investigated if an enhancement of NK-cell-mediated cytotoxicity against MM could be reached by blocking of the inhibitory leukocyte immunoglobulin-like receptor 1 (LIR-1). Our investigations revealed high levels of LIR-1 expression not only on the NK cell line NK-92, but also on myeloma cells (MOLP-8, RPMI8226) as well as on a lymphoblastoid cell line (LBCL; IM-9). Subsequent cytotoxicity assays were designed to show the isolated effects of LIR-1 blocking on either the effector or the tumor side to rule out receptor-receptor interactions. Although NK-92 was shown to be capable of myeloma cell lysis, inhibition of LIR-1 on NK-92 did not enhance cytotoxicity. Targeting the receptor on MM and LBCL did not also alter NK-92-mediated lysis. We come to the conclusion that LIR-1 alone does not directly influence NK-cell-mediated cytotoxicity against myeloma. To our knowledge, this work provides the first investigation of the inhibitory capability of LIR-1 in NK-92-mediated cytotoxicity against MM and the first functional evaluation of LIR-1 on MM and LBCL

Компаундирование компонентов высокооктановых бензинов

Объектом исследования является процесс компаундирования товарных бензинов. Цель работы – оптимизация работы установки компаундирования товарных бензинов. Результаты работы подтвердили целесообразность использования компьютерной моделирующей системы для разработки рецептур смешения высокооктановых бензинов. В экономической части рассчитана трудоемкость выполненных работ, временные показатели проведения работ, материальные затраты.The object of the study is the process of compounding commercial gasolines. The aim of the work is to optimize the work of the compounding of commercial gasolines. The results of the work confirmed the expediency of using a computer modeling system for developing formulas for mixing high-octane gasolines. In the economic part, labor intensity of the work performed, time performance indicators, material costs are calculated

Disorder-Induced Depinning Transition

The competition in the pinning of a directed polymer by a columnar pin and a background of random point impurities is investigated systematically using the renormalization group method. With the aid of the mapping to the noisy-Burgers' equation and the use of the mode-coupling method, the directed polymer is shown to be marginally localized to an arbitrary weak columnar pin in 1+1 dimensions. This weak localization effect is attributed to the existence of large scale, nearly degenerate optimal paths of the randomly pinned directed polymer. The critical behavior of the depinning transition above 1+1 dimensions is obtained via an $\epsilon$-expansion.Comment: 47 pages in revtex; postscript files of 6 figures include

Evaluation of noise regression techniques in resting-state fMRI studies using data of 434 older adults

Subject motion is a well-known confound in resting-state functional MRI (rs-fMRI) and the analysis of functional connectivity. Consequently, several clean-up strategies have been established to minimize the impact of subject motion. Physiological signals in response to cardiac activity and respiration are also known to alter the apparent rs-fMRI connectivity. Comprehensive comparisons of common noise regression techniques showed that the Independent Component Analysis based strategy for Automatic Removal of Motion Artifacts (ICA-AROMA) was a preferred pre-processing technique for teenagers and adults. However, motion and physiological noise characteristics may differ substantially for older adults. Here, we present a comprehensive comparison of noise-regression techniques for older adults from a large multi-site clinical trial of exercise and intensive pharmacological vascular risk factor reduction. The Risk Reduction for Alzheimer\u27s Disease (rrAD) trial included hypertensive older adults (60-84 years old) at elevated risk of developing Alzheimer\u27s Disease (AD). We compared the performance of censoring, censoring combined with global signal regression, non-aggressive and aggressive ICA-AROMA, as well as the Spatially Organized Component Klassifikator (SOCK) on the rs-fMRI baseline scans from 434 rrAD subjects. All techniques were rated based on network reproducibility, network identifiability, edge activity, spatial smoothness, and loss of temporal degrees of freedom (tDOF). We found that non-aggressive ICA-AROMA did not perform as well as the other four techniques, which performed table with marginal differences, demonstrating the validity of these techniques. Considering reproducibility as the most important factor for longitudinal studies, given low false-positive rates and a better preserved, more cohesive temporal structure, currently aggressive ICA-AROMA is likely the most suitable noise regression technique for rs-fMRI studies of older adults