Cardiac atrioventricular junctional tissues in hearts from infants who died suddenly

The cause of sudden infant death syndrome is not known at present. Most agree that in the majority of cases it involves primary apnea. However, cardiac abnormalities probably account for a subset of these deaths. An investigation into the structure of the atrioventricular (A V) junctional tissues of the heart would provide insight into the frequency of sudden death in infants that might result from abnormal cardiac morphology. The hearts of seven infants who died from diagnosed sudden infant death syndrome were examined by serially sectioning and studying this critical region of the heart.The hearts of these infants could be divided into three groups on the basis of their morphologic features. In the first group, represented by two cases, there were marked variations from normal, the most striking feature being the presence of accessory pathways. In the second group, represented by four cases, the A V junctional tissues were not fully mature and clusters of AY nodal and bundle cells were dispersed throughout the anulus fibrosus. In the third group, the structure of the junctional tissues was normal. There remains a distinct subset of infants who might have died suddenly and unexpectedly from cardiac abnormalities that needs to be more completely defined

The Effect of Randomized School Admissions on Voter Participation

There is little causal evidence on the effect of economic and policy outcomes on voting behavior. This paper uses randomized outcomes from a school choice lottery to examine if lottery outcomes affect voting behavior in a school board election. We show that losing the lottery has no significant impact on overall voting behavior; however, among white families, those with above median income and prior voting history, lottery losers were significantly more likely to vote than lottery winners. Using propensity score methods, we compare the voting of lottery participants to similar families who did not participate in the lottery. We find that losing the school choice lottery caused an increase in voter turnout among whites, while winning the lottery had no effect relative to non-participants. Overall, our empirical results lend support to models of expressive and retrospective voting, where likely voters are motivated to vote by past negative policy outcomes.

Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis.

The role of the CXC chemokine ligand 9 (CXCL9) in host defense following infection with mouse hepatitis virus (MHV) was determined. Inoculation of the central nervous system (CNS) of CXCL9-/- mice with MHV resulted in accelerated and increased mortality compared to wild type mice supporting an important role for CXCL9 in anti-viral defense. In addition, infection of RAG1-/- or CXCL9-/- mice with a recombinant MHV expressing CXCL9 (MHV-CXCL9) resulted in protection from disease that correlated with reduced viral titers within the brain and NK cell-mediated protection in the liver. Survival in MHV-CXCL9-infected CXCL9-/- mice was associated with reduced viral burden within the brain that coincided with increased T cell infiltration. Similarly, viral clearance from the livers of MHV-CXCL9-infected mice was accelerated but independent of increased T cell or NK cell infiltration. These observations indicate that CXCL9 promotes protection from coronavirus-induced neurological and liver disease

A Potential Super-Venus in the Kepler-69 System

Transiting planets have greatly expanded and diversified the exoplanet field. These planets provide greater access to characterization of exoplanet atmospheres and structure. The Kepler mission has been particularly successful in expanding the exoplanet inventory, even to planets smaller than the Earth. The orbital period sensitivity of the Kepler data is now extending into the habitable zones of their host stars, and several planets larger than the Earth have been found to lie therein. Here we examine one such proposed planet, Kepler-69c. We provide new orbital parameters for this planet and an in-depth analysis of the habitable zone. We find that, even under optimistic conditions, this 1.7 R_⊕ planet is unlikely to be within the habitable zone of Kepler-69. Furthermore, the planet receives an incident flux of 1.91 times the solar constant, which is similar to that received by Venus. We thus suggest that this planet is likely a super-Venus rather than a super-Earth in terms of atmospheric properties and habitability, and we propose follow-up observations to disentangle the ambiguity

Factors Affecting Users’ Decisions to Migrate from Initial Use of Information Technology to Continuing Use

Supervisor: Dr. Patrick J. FahyCommunity college teachers completed survey and interview questions designed to elicit data on reasons for continuing use of web-based educational technology. The data were analyzed in relationship to two models of innovative technology evaluation. The research sample was small. Nonetheless, the data demonstrated a good relationship with the Technology Acceptance Model (TAM). Responses concerning “usefulness” and “ease of use” rated high among the identified influences. The data did not relate as well with the innovation attributes identified by the “Diffusion of Innovations” model. The results point to the value of continuing research. Two limitations in this study point to the necessity of conducting such research. One of these was the small sample; the other was the concentration on continuing users rather than the inclusion of subjects who stopped using the system after their first trial