288 research outputs found
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Predictability of frontal waves and cyclones
The statistical properties and skill in predictions of objectively identified and tracked cyclonic features (frontal waves and cyclones) are examined in MOGREPS-15, the global 15-day version of the Met Office Global and Regional Ensemble Prediction System (MOGREPS). The number density of cyclonic features is found to decline with increasing lead-time, with analysis fields containing weak features which are not sustained past the first day of the forecast. This loss of cyclonic features is associated with a decline in area averaged enstrophy with increasing lead time. Both feature number density and area averaged enstrophy saturate by around 7 days into the forecast. It is found that the feature number density and area averaged enstrophy of forecasts produced using model versions that include stochastic energy backscatter saturate at higher values than forecasts produced without stochastic physics. The ability of MOGREPS-15 to predict the locations of cyclonic features of different strengths is evaluated at different spatial scales by examining the Brier Skill (relative to the analysis climatology) of strike probability forecasts: the probability that a cyclonic feature center is located within a specified radius. The radius at which skill is maximised increases with lead time from 650km at 12h to 950km at 7 days. The skill is greatest for the most intense features. Forecast skill remains above zero at these scales out to 14 days for the most intense cyclonic features, but only out to 8
days when all features are included irrespective of intensity
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The added value of convection-permitting ensemble forecasts of sea breeze compared to a Bayesian forecast driven by the global ensemble
Dynamical downscaling of ensemble forecasts to convectionpermitting resolutions aims to improve forecast skill by explicitly
resolving mesoscale dynamical features. The success of this approach is dependent on the ability of the model to spin up smaller
features embedded in the larger scale flow and provide more local information than could be inferred from knowledge of the
climatological response to the large scale flow alone. Here we
test whether such additional information is obtained from the
Met Office Global and Regional Ensemble Prediction Systems
(MOGREPS) for the sea-breeze phenomena which is resolved
properly only at convection-permitting resolutions but is driven
by large-sale conditions that are well represented in the global
driving model. The sea breeze is detected using a new automatic
tracking algorithm suitable for use in convective-scale forecast
data. The skill of probabilistic forecasts of sea-breeze occurrence from the high resolution ensemble is compared to that of a
Bayesian forecast trained on paired high/low resolution ensemble
members. This creates a statistical forecast of the high-resolution
ensemble member given knowledge of the global forecast ensemble alone. The aim of this paper is twofold: -firstly to assess
whether the information about sea breeze occurrence is encoded
in a few large-scale parameters and can be forecast by a statistical
method ; secondly to estimate what information is gained by running the high resolution forecast beyond that which is contained
in these large-scale flow parameters. Comparison of the two
forecasting methods using a variety of verification methods all
lead to the same conclusion: although both the Bayesian forecast
and convection-permitting ensemble provide information about
sea-breeze occurrence, the convection-permitting ensemble is
significantly more able to discriminate between sea-breeze events
and non-events for all lead times
Projective dynamics and first integrals
We present the theory of tensors with Young tableau symmetry as an efficient
computational tool in dealing with the polynomial first integrals of a natural
system in classical mechanics. We relate a special kind of such first
integrals, already studied by Lundmark, to Beltrami's theorem about
projectively flat Riemannian manifolds. We set the ground for a new and simple
theory of the integrable systems having only quadratic first integrals. This
theory begins with two centered quadrics related by central projection, each
quadric being a model of a space of constant curvature. Finally, we present an
extension of these models to the case of degenerate quadratic forms.Comment: 39 pages, 2 figure
Probing BFKL Dynamics in the Dijet Cross Section at Large Rapidity Intervals in ppbar Collisions at sqrt{s}=1800 and 630 GeV
Inclusive dijet production at large pseudorapidity intervals (delta_eta)
between the two jets has been suggested as a regime for observing BFKL
dynamics. We have measured the dijet cross section for large delta_eta in ppbar
collisions at sqrt{s}=1800 and 630 GeV using the DO detector. The partonic
cross section increases strongly with the size of delta_eta. The observed
growth is even stronger than expected on the basis of BFKL resummation in the
leading logarithmic approximation. The growth of the partonic cross section can
be accommodated with an effective BFKL intercept of
a_{BFKL}(20GeV)=1.65+/-0.07.Comment: Published in Physical Review Letter
Search for Top Squark Pair Production in the Dielectron Channel
This report describes the first search for top squark pair production in the
channel stop_1 stopbar_1 -> b bbar chargino_1 chargino_1 -> ee+jets+MEt using
74.9 +- 8.9 pb^-1 of data collected using the D0 detector. A 95% confidence
level upper limit on sigma*B is presented. The limit is above the theoretical
expectation for sigma*B for this process, but does show the sensitivity of the
current D0 data set to a particular topology for new physics.Comment: Five pages, including three figures, submitted to PRD Brief Report
ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression
Aberrant glycosylation is a universal feature of cancer cells, and cancer-associated glycans have been detected in virtually every cancer type. A common change in tumour cell glycosylation is an increase in α2,6 sialylation of N-glycans, a modification driven by the sialyltransferase ST6GAL1. ST6GAL1 is overexpressed in numerous cancer types, and sialylated glycans are fundamental for tumour growth, metastasis, immune evasion, and drug resistance, but the role of ST6GAL1 in prostate cancer is poorly understood. Here, we analyse matched cancer and normal tissue samples from 200 patients and verify that ST6GAL1 is upregulated in prostate cancer tissue. Using MALDI imaging mass spectrometry (MALDI-IMS), we identify larger branched α2,6 sialylated N-glycans that show specificity to prostate tumour tissue. We also monitored ST6GAL1 in plasma samples from >400 patients and reveal ST6GAL1 levels are significantly increased in the blood of men with prostate cancer. Using both in vitro and in vivo studies, we demonstrate that ST6GAL1 promotes prostate tumour growth and invasion. Our findings show ST6GAL1 introduces α2,6 sialylated N-glycans on prostate cancer cells and raise the possibility that prostate cancer cells can secrete active ST6GAL1 enzyme capable of remodelling glycans on the surface of other cells. Furthermore, we find α2,6 sialylated N-glycans expressed by prostate cancer cells can be targeted using the sialyltransferase inhibitor P-3FAX-Neu5Ac. Our study identifies an important role for ST6GAL1 and α2,6 sialylated N-glycans in prostate cancer progression and highlights the opportunity to inhibit abnormal sialylation for the development of new prostate cancer therapeutics
Measurement of the Top Quark Mass Using Dilepton Events
The D0 collaboration has performed a measurement of the top quark mass based
on six candidate events for the process t tbar -> b W+ bbar W-, where the W
bosons decay to e nu or mu nu. This sample was collected during an exposure of
the D0 detector to an integrated luminosity of 125 pb^-1 of sqrt(s)=1.8 TeV
p-pbar collisions. We obtain mt = 168.4 +- 12.3 (stat) +- 3.7 (sys) GeV/c^2,
consistent with the measurement obtained using single-lepton events.
Combination of the single-lepton and dilepton results yields mt = 172.0 +- 7.5
GeV/c^2.Comment: 12 pages, 3 figure
Differential Production Cross Section of Z Bosons as a Function of Transverse Momentum at sqrt{s}=1.8 TeV
We present a measurement of the transverse momentum distribution of Z bosons
produced in ppbar collisions at sqrt{s}=1.8 TeV using data collected by the D0
experiment at the Fermilab Tevatron Collider during 1994--1996. We find good
agreement between our data and a current resummation calculation. We also use
our data to extract values of the non-perturbative parameters for a particular
version of the resummation formalism, obtaining significantly more precise
values than previous determinations.Comment: 10 pages, 2 figures, submitted to Phys. Rev. Letters v2 has margin
error correcte
Search for Squarks and Gluinos in Events Containing Jets and a Large Imbalance in Transverse Energy
Using data corresponding to an integrated luminosity of 79 pb-1, D0 has
searched for events containing multiple jets and large missing transverse
energy in pbar-p collisions at sqrt(s)=1.8 TeV at the Fermilab Tevatron
collider. Observing no significant excess beyond what is expected from the
standard model, we set limits on the masses of squarks and gluinos and on the
model parameters m_0 and m_1/2, in the framework of the minimal low-energy
supergravity models of supersymmetry. For tan(beta) = 2 and A_0 = 0, with mu <
0, we exclude all models with m_squark < 250 GeV/c^2. For models with equal
squark and gluino masses, we exclude m < 260 GeV/c^2.Comment: 10 pages, 3 figures, Submitted to PRL, Fixed typo on page bottom of
p. 6 (QCD multijet background is 35.4 events
Search for bottom squarks in pbarp collisions at sqrt(s)=1.8 TeV
We report on a search for bottom squarks produced in pbarp collisions at
sqrt(s) = 1.8 TeV using the D0 detector at Fermilab. Bottom squarks are assumed
to be produced in pairs and to decay to the lightest supersymmetric particle
(LSP) and a b quark with branching fraction of 100%. The LSP is assumed to be
the lightest neutralino and stable. We set limits on the production cross
section as a function of bottom squark mass and LSP mass.Comment: 5 pages, Latex. submitted 3-12-1999 to PRD - Rapid Communicatio
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