Induced gamma band responses predict recognition delays during object identification

Peer reviewedPublisher PD

Ab-initio calculations of carbon and boron nitride allotropes and their structural phase transitions using periodic coupled cluster theory

We present an ab-initio study of boron nitride as well as carbon allotropes. Their relative thermodynamic stabilities and structural phase transitions from low- to high-density phases are investigated. Pressure-temperature phase diagrams are calculated and compared to experimental findings. The calculations are performed using quantum chemical wavefunction based as well as density functional theories. Our findings reveal that predicted energy differences often depend significantly on the choice of the employed method. Comparison between calculated and experimental results allows for benchmarking the accuracy of various levels of theory. The produced results show that quantum chemical wavefunction based theories allow for achieving systematically improvable estimates. We find that on the level of coupled cluster theories the low- and high-density phases of boron nitride become thermodynamically degenerate at 0 K. This is in agreement with recent experimental findings, indicating that cubic boron nitride is not the thermodynamically stable allotrope at ambient conditions. Furthermore we employ the calculated results to assess transition probabilities from graphitic low-density to diamond-like high-density phases in an approximate manner. We conclude that the stacking order of the parent graphitic material is crucial for the possible formation of meta-stable wurtzite boron nitride and hexagonal carbon diamond also known as lonsdaleite

Induced gamma-band activity is related to the time point of object identification

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Working Capital Management in der wertorientierten Unternehmenssteuerung bei Siemens Transformers

Die Erhöhung operativer Cash Flows führt nach dem Discounted-Cash-Flow-Modell unmittelbar zu einer Unternehmenswertsteigerung. Die Praxis der wertorientierten Unternehmensführung misst demgegenüber den Erfolg zumeist auf Basis des Economic Value Added. In diesem Konzept schlagen sich Cash-Flow-Verbesserungen nur mittelbar durch reduzierte Kapitalkosten erfolgserhöhend nieder. Die Siemens AG hat den Zusammenhang von Cash Flows, Kapitaleffizienz und Wertsteigerung frühzeitig erkannt und im Jahr 2007 ihr Konzept der wertorientierten Unternehmensführung weiterentwickelt. Seitdem werden auf Basis der Cash Conversion Rate Cash-Flow-Wirkungen unmittelbar berücksichtigt. Am Beispiel des Working Capital Managements bei Siemens Transformers wird das neue Steuerungskonzept im Hinblick auf die Incentivierung des Managements und die Umsetzung operativer Maßnahmen untersucht.Based on the Discounted Cash Flow Model an increase of the Operating Cash Flow leads to an immediate effect on value creation. The practice of value based management however, predominantly measures corporate performance based on Economic Value Added. This concept considers improvements in cash flow only indirectly through a reduction in the cost of capital. Siemens AG recognized the importance of combining cash flow, capital efficiency and value creation and adapted their concept of value based management in 2007. Since then cash flow changes are directly reflected through the cash conversion rate. This paper analyses the effects of the new management concept on the incentives for the management and the execution of operational measures based on the example of the Working Capital Management at Siemens Transformers

Coding of visual object features and feature conjunctions in the human brain

Peer reviewedPublisher PD

Reduced CD40L expression on ex vivo activated CD4+T-lymphocytes from patients with excellent renal allograft function measured with a rapid whole blood flow cytometry procedure

Background: The CD40-CD40L (CD154) costimulatory pathway plays a critical role in the pathogenesis of kidney allograft rejection. In renal transplant biopsies, CD4+ CD40L+ graft-infiltrating cells were detected during chronic rejection in contrast to acute rejection episodes. Using a rapid noninvasive FACS procedure, we were able to demonstrate CD40L upregulation in peripheral blood of patients with chronic renal allograft dysfunction. Materials and Methods: Whole blood from recipients of renal allografts was stimulated with PMA and ion-omycin and measured by flow cytometry. Patients were assigned to three groups based on transplant function. Group 1: 26 patients with excellent renal transplant function; group 2: 28 patients with impaired transplant function; group 3: 14 patients with chronic allograft dysfunction and group 4: 8 healthy controls. Results: The median percentage +/-SEM of CD4+/ CD40L+ cells stimulated ex vivo at 10 ng/ml PMA was as follows: group 1: 28.3 +/- 4.1%; group 2: 18.4 +/- 2.4%; group 3: 50.1 +/- 5.0% and group 4: 40.4 +/- 3.4%. Subdivisions of groups 2 and 3 resulted in different CD40L expression patterns. Patients with increased serum creatinine since the initial phase after transplantation ( groups 2a and 3a) revealed a higher percentage of CD4+ CD40L+ cells than patients showing a gradual increase over time ( groups 2b and 3b). Consequently, patients of group 3a exhibited a significantly reduced transplant function compared with those of group 3b. Conclusion: After PMA + ionomycin stimulation, patients with excellent kidney graft function displayed significantly reduced expression of CD40L surface molecules on CD4+ cells early after transplantation. Those with a chronic dysfunction of the renal graft showed significantly more CD4+ cells expressing CD40L compared to the other transplanted groups. These results demonstrate that the percentage of CD4+ CD40L+ cells stimulated ex vivo in peripheral blood may be a valuable marker for chronic allograft nephropathy. Copyright (C) 2004 S. Karger AG, Basel

Induced Gamma-band Activity Elicited by Visual Representation of Unattended Objects

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Topology of dynamical lattice configurations including results from dynamical overlap fermions

We investigate how the topological charge density in lattice QCD simulations is affected by violations of chiral symmetry in different fermion actions. To this end we compare lattice configurations generated with a number of different actions including first configurations generated with exact overlap quarks. We visualize the topological profiles after mild smearing. In the topological charge correlator we measure the size of the positive core, which is known to vanish in the continuum limit. To leading order we find the core size to scale linearly with the lattice spacing with the same coefficient for all actions, even including quenched simulations. In the subleading term the different actions vary over a range of about 10 %. Our findings suggest that non-chiral lattice actions at current lattice spacings do not differ much for this specific observable related to topology, both among themselves and compared to overlap fermions.Comment: 7 pages, talk presented at The XXIX International Symposium on Lattice Field Theory - Lattice 2011, July 10-16, 2011, Squaw Valley, Lake Tahoe, Californi

PRIMING OF OBJECT CATEGORIZATION WITHIN AND ACROSS LEVELS OF SPECIFICITY

Identification of objects can occur at different levels of specificity. Dependingon task and context, an object can be classified at the superordinate level (as ananimal), at the basic level (a bird) or at the subordinate level (a sparrow). Whatare the interactions between these representational levels and do they rely onthe same sequential processes that lead to successful object identification? Inthis electroencephalogram study, a task-switching paradigm (covert naming orliving/non-living judgment) was used. Images of objects were repeated eitherwithin the same task, or with a switch from a covert naming task to a livingor non-living judgment and vice versa. While covert naming accesses entrylevel(basic or subordinate), living/non-living judgments rely on superordinateclassification. Our beha-vioural results demonstrated clear priming effectswithin both tasks. However, asymmetries were found when task-switching hadoccurred, with facilitation for covert naming but not for categorization. Wealso found lower accuracy and early-starting and persistent enhancements ofevent-related potentials (ERPs) for covert naming, indicating that this task wasmore difficult and involved more intense perceptual and semantic processing.Perceptual priming was marked by consistent reductions of the ERP componentL1 for repeated presentations, both with and without task switching. Additionalrepetition effects were found in early event-related activity between 150-190 ms(N1) when a repeated image had been named at initial presentation. We conclude that differences in N1 indicate task-related changes in the identification processitself. Such enhancements for covert naming again emerge in a later timewindow associated with depth of semantic processing. Meanwhile, L1 reflectsmodulations due to implicit memory of objects. In conclusion, evidence wasfound for representational overlap; changes in ERP markers started early andrevealed cross-task priming at the level of object structure analysis and moreintense perceptual and semantic processing for covert naming

First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI)

The objective of this pilot clinical study was to assess the safety, technical feasibility, pharmacokinetic (PK) profile and tumour response of DC Bead™ with irinotecan (DEBIRI™) delivered by intra-arterial embolisation for the treatment of metastatic colorectal cancer. Eleven patients with unresectable liver metastases from CRC, tumour burden <30% of liver volume, adequate haematological, liver and renal function, performance status of <2 were included in this study. Patients received up to 4 sessions of TACE with DEBIRI at 3-week intervals. Feasibility of the procedure, safety and tumour response were assessed after each cycle. PK was measured after the first cycle. Patients were followed up to 24 weeks. Only mild to moderate adverse events were observed. DEBIRI is a technically feasibile procedure; no technical complications were observed. Average Cmax for irinotecan and SN-38 was 194 ng/ml and 16.7 ng/ml, respectively, with average t½ of 4.6 h and 12.4 h following administration of DEBIRI. Best overall response during the study showed disease control in 9 patients (2 patients with partial response and 7 with stable disease, overall response rate of 18%). Our study shows that transarterial chemoembolisation with irinotecan-loaded DC beads (DEBIRI) is safe, technically feasible and effective with a good PK profile