M@TE - Monitoring at TeV Energies

Blazars are extremely variable objects emitting radiation across the electromagnetic spectrum and showing variability on time scales from minutes to years. For the understanding of the emission mechanisms, simultaneous multi-wavelength observations are crucial. Various models for flares predict simultaneous flux increases in the X-ray and gamma-ray band or more complex variability patterns, depending on the dominant process responsible for the gamma-ray emission. Monitoring at TeV energies is providing important information to distinguish between different models. To study duty cycle and variability time scales of an object, an unbiased data sample is essential, and good sensitivity and continuous monitoring are needed to resolve smaller time scales. A dedicated long-term monitoring program at TeV energies has been started by the FACT project. Its success clearly illustrated that the usage of silicon based photo sensors (SIPMs) is ideal for long-term monitoring. They provide not only an excellent and stable detector performance, but also allow for observations during bright ambient light minimizing observational gaps and increasing the instrument's duty cycle. The observation time in a single longitude is limited to 6 hours. To study typical variability time scales of few hours to one day, the ultimate goal is 24/7 monitoring with a network of small telescopes around the globe (DWARF project). The installation of an Imaging Air Cherenkov Telescope is planned in San Pedro Martir, Mexico. For the M@TE (Monitoring at TeV energies) telescope, a mount from a previous experiment is being refurbished to be equipped with a camera using the new generation of SiPMs. In the presentation, the status of the M@TE project will be reported outlining the scientific potential, including the possibility to extend monitoring campaigns to 12 hours by coordinated observations together with FACT.Comment: 5 pages, 1 figure. Contribution to the 6th International Symposium on High Energy Gamma-Ray Astronomy (Gamma2016), Heidelberg, Germany. To be published in the AIP Conference Proceeding

Contributions of ambient assisted living for health and quality of life in the elderly and care services - a qualitative analysis from the experts’ perspective of care service professionals

BACKGROUND: Because of the demographic change in industrial countries new technical solutions for the independent living of elderly will become important in the next years. Ambient Assisted Living seeks to address the upcoming challenges by providing technical aids for elderly and care givers. Therefore it is crucial to understand how those socio-technical solutions can address their needs and quality of life (QOL). The aim of this study was to analyse the main needs of dependent elderly and to investigate how different solutions can contribute to health and quality of life. METHODS: A qualitative study design consisting of interviews with 11 professionals of geriatric care organisations was chosen. The data analysis was done by applying the qualitative content analysis by Philipp Mayring. The analysis was based on the basic principle of the bio-psycho-social model of health RESULTS: Ambient Assisted Living solutions and assistive technologies can have positive impacts on different dimensions of health and quality of life. The needs and problems of elderly can be addressed by applying appropriate solutions which influence the physical, mental and social dimensions of quality of life. There are also benefits for social care providers, their staff and caring relatives of impaired elderly. Ambient Assisted Living solutions can also be used as a facilitator for operational optimization of care services. CONCLUSIONS: Solutions for telemedicine and telecare which are connected to Ambient Assisted Living solutions will have the biggest positive impact on care giving services. Also simple technical aids can be beneficial for elderly to enhance QOL by enabling autonomy in their familiar surroundings

Detection of Very-High Energy Gamma-Rays from the BL Lac Object PG 1553+113 with the MAGIC Telescope

The MAGIC telescope has observed very-high energy gamma-ray emission from the BL Lac object PG 1553+113 in 2005 and 2006 at an overall significance is 8.8 sigma. The light curve shows no significant flux variations on a daily timescale. The flux level during 2005 was, however, significantly higher as compared to 2006. The differential energy spectrum between approx. 90 GeV and 500 GeV is well described by a power law with a spectral index of -4.2+-0.3. The photon energy spectrum and spectral modeling allow to pose upper limits of z=0.74 and z=0.56, respectively, on the yet undetermined redshift of PG 1553+113. Recent VLT observations of this blazar show featureless spectra in the near-IR, thus no direct redshift could be determined from these measurements.Comment: 4 pages, 4 figures, to appear in the proceedings of the 30th International Cosmic Ray Conference, Merida, July 200

Real-world Quantum Sensors: Evaluating Resources for Precision Measurement

Quantum physics holds the promise of enabling certain tasks with better performance than possible when only classical resources are employed. The quantum phenomena present in many experiments signify nonclassical behavior, but do not always imply superior performance. Quantifying the enhancement achieved from quantum behavior requires careful analysis of the resources involved. We analyze the specific case of parameter estimation using an optical interferometer, where increased precision can be achieved using quantum probe states. Common performance measures are examined and it is shown that some overestimate the improvement. For the simplest experimental case we compare the different measures and show this overestimate explicitly. We give the preferred analysis of real-world experiments and calculate benchmark values for experimental parameters necessary to realize a precision enhancement.Comment: 8 pages, 3 figure

East-West gradient in cardio-vascular mortality in Austria: how much can we explain by following the pattern of risk factors?

<p>Abstract</p> <p>Background</p> <p>Various studies show major regional differences in the prevalence of cardio-vascular disease morbidity and mortality, both in Europe and within European countries. In Austria, these differences are documented by an East-West gradient with declining morbidity and mortality rates when moving from the East to the West of the country. It was the aim of this study to analyse if, and to what extent, socio-demographic and socio-economic determinants, social resources and health behaviour can contribute to the clarification of this East-West gradient by conducting secondary analyses of an existing Austrian health dataset.</p> <p>Results</p> <p>The data were analysed using bivariate analyses, as well as univariate and multivariate logistic regression models. These analyses revealed significant East-West gradients for various risk factors, as well as socio-demographic and socio-economic health determinants. There was a gradual decrease of hypertension, diabetes mellitus, obesity, and psycho-social discomfort in both sexes, with the highest prevalences in those Austrian regions with the highest cardio-vascular mortality and a stepwise decrease to the regions with the lowest cardio-vascular mortality. Controlling for educational level significantly raised the odds for diabetes, hypertension and obesity. In the results of the multivariate analyses, factors that significantly and independently predicted diabetes mellitus were geographic location, psycho-social discomfort, lack of physical exercise, and age in both sexes. For women these factors additionally included a low educational level, lack of social support, and being born abroad.</p> <p>Conclusions</p> <p>Our study shows a clear gradual decline of cardio-vascular mortality and some of its risk factors from East to West in Austria. Concerning these risk factors, the geographic region and psycho-social discomfort showed the greatest association with diabetes mellitus, hypertension, and obesity. Hence, they contribute to the explanation of the variance in spatial cardio-vascular disease mortality. Yet, a large proportion of this variance remains unexplained. It would be of great importance to public health and preventive measures to take a closer look at spatial differences in cardio-vascular disease morbidity and mortality to better tailor programmes to the regional environments and settings. Our results also call for a greater importance of preventative measures for psycho-social discomfort and increase of social support.</p

Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case control study

Peptidylarginine deiminase type 4 (PADI4) genotypes were shown to influence susceptibility to rheumatoid arthritis ( RA) in the Japanese population. Such an association could not previously be confirmed in different European populations. In the present study, we analysed exons 2 - 4 of PADI4 in 102 German RA patients and 102 healthy individuals to study the influence of PADI4 variability on RA susceptibility by means of haplotype-specific DNA sequencing. Analyses of the influence of PADI4 and HLA-DRB1 genotypes on disease activity and on levels of anti-cyclic citrullinated peptide antibodies were performed. Comparing the frequencies of PADI4 haplotype 4 (padi4\_89* G, padi4\_90* T, padi4\_92* G, padi4\_94* T, padi4\_104* C, padi4\_95* G, padi4\_96* T) ( patients, 14.7%; controls, 7.8%; odds ratio = 2.0, 95% confidence interval = 1.1 - 3.8) and carriers of this haplotype ( patients, 27.5%; controls, 13.7%; odds ratio = 2.4, 95% confidence interval = 1.2 - 4.8), a significant positive association of PADI4 haplotype 4 with RA could be demonstrated. Other PADI4 haplotypes did not differ significantly between patients and controls. Regarding the individual PADI4 variants, padi4\_89 ( A. G), padi4\_90 (C --> T), and padi4\_94 (C --> T) were significantly associated with RA ( patients, 49.5%; controls, 38.7%; odds ratio = 1.6, 95% confidence interval = 1.1 - 2.3). Considering novel PADI4 variants located in or near to exons 2, 3, and 4, no quantitative or qualitative differences between RA patients (8.8%) and healthy controls (10.8%) could be demonstrated. While the PADI4 genotype did not influence disease activity and the anticyclic citrullinated peptide antibody level, the presence of the HLA-DRB1 shared epitope was significantly associated with higher anti-cyclic citrullinated peptide antibody levels ( P = 0.033). The results of this small case - control study support the hypothesis that variability of the PADI4 gene may influence susceptibility to RA in the German population. Quantitative or qualitative differences in previously undefined PADI4 variants between patients and controls could not be demonstrated