60 research outputs found

    The N=4 effective action of type IIA supergravity compactified on SU(2)-structure manifolds

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    We study compactifications of type IIA supergravity on six-dimensional manifolds with SU(2) structure and compute the low-energy effective action in terms of the non-trivial intrinsic torsion. The consistency with gauged N=4 supergravity is established and the gauge group is determined. Depending on the structure of the intrinsic torsion, antisymmetric tensor fields can become massive.Comment: 29 pages, latex, v2: minor corrections, added references, published versio

    Imaging of Red-Shifted Light From Bioluminescent Tumors Using Fluorescence by Unbound Excitation From Luminescence

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    Early detection of tumors is today a major challenge and requires sensitive imaging methodologies coupled with new efficient probes. In vivo optical bioluminescence imaging has been widely used in the field of preclinical oncology to visualize tumors and several cancer cell lines have been genetically modified to provide bioluminescence signals. However, the light emitted by the majority of commonly used luciferases is usually in the blue part of the visible spectrum, where tissue absorption is still very high, making deep tissue imaging non-optimal, and calling for optimized optical imaging methodologies. We have previously shown that red-shifting of bioluminescence signal by Fluorescence Unbound Excitation from Luminescence (FUEL) is a mean to increase bioluminescence signal sensitivity detection in vivo. Here, we applied FUEL to tumor detection in two different subcutaneous tumor models: the auto-luminescent human embryonic kidney (HEK293) cell line and the murine B16-F10 melanoma cell line previously transfected with a plasmid encoding the Luc2 firefly luciferase. Tumor size and bioluminescence were measured over time and tumor vascularization characterized. We then locally injected near infrared emitting Quantum Dots (NIR QDs) in the tumor site and observed a red-shifting of bioluminescence signal by (FUEL) indicating that FUEL could be used to allow deeper tumor detection in mice

    Type IIA orientifold compactification on SU(2)-structure manifolds

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    We investigate the effective theory of type IIA string theory on six-dimensional orientifold backgrounds with SU(2)-structure. We focus on the case of orientifolds with O6-planes, for which we compute the bosonic effective action in the supergravity approximation. For a generic SU(2)-structure background, we find that the low-energy effective theory is a gauged N=2 supergravity where moduli in both vector and hypermultiplets are charged. Since all these supergravities descend from a corresponding N=4 background, their scalar target space is always a quotient of a SU(1,1)/U(1) x SO(6,n)/SO(6)xSO(n) coset, and is therefore also very constrained.Comment: 31 pages; v2: local report number adde

    Synchronization of mutually delay-coupled non-identical quantum cascade lasers

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    The rate equations for two delayed coupled quantum cascade lasers (QCLs) are investigated analytically in the limit of weak coupling and small frequency detuning. Our analysis is motivated by the observations of Bogris et al (IEEE J. Sel. Top. Quant. 23, 1500107 (2017)) who found higher sensing performances when one laser is operating close to threshold. We show that the previously determined coupled delayed Adler equations fail to describe this particular limit and derive equations for a single mode optically injected laser where the delay is no more present into the arguments of the dependent variables
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