Endothelin stimulates PDGF secretion in cultured human mesangial cells

Endothelin stimulates PDGF secretion in cultured human mesangial cells. Endothelin, a 17-DKa peptide originally described as a potent vasoconstrictor, also stimulates the release of important regulators of glomerular hemodynamics such as atrial natriuretic factor and renin. In the present study we investigated the role of endothelin in the release of another potent vasoconstrictor and mitogen of human mesangial cells, the platelet-derived growth factor. Endothelin stimulated PDGF release at 12 hours and the effect was sustained for 36 hours. This effect was associated with the enhanced induction of mRNAs encoding PDGF A-and B-chain. Endothelin also induced mitogenesis in human mesangial cells which was accompanied by activation of phospholipase C with increased inositol phosphate turnover. These data suggest a mechanism by which endothelin may regulate mesangial cell function in disease states

Facing Forward, Looking Back: Religion and Film Studies in the Last Decade

On November 17, 2012, at the American Academy of Religion’s National Meeting, the Religion, Film, and Visual Culture Group sponsored a session entitled, “Facing Forward, Looking Back: Religion and Film Studies in the Last Decade.” The session focused on four recent books in the field of Religion and Film: John Lyden’s Film as Religion: Myths, Morals and Rituals (NYU, 2003); S. Brent Plate’s Religion and Film: Cinema and the Re-Creation of the World (Wallflower Press, 2009); Antonio Sison’s World Cinema, Theology, and the Human: Humanity in Deep Focus (Routledge, 2012); and Sheila Nayar’s The Sacred and the Cinema: Reconfiguring the ‘Genuinely’ Religious Film (Continuum, 2012). Each author was present to make remarks on his or her book, and then three respondents made remarks on each of the books as well. The respondents were Stefanie Knauss, Rachel Wagner, and Jolyon Thomas. Joe Kickasola introduced the session, and moderated the discussion that followed. This session represented a rare opportunity for scholars of the field of Religion and Film to reflect on the past, present, and future directions of the field, and the Journal of Religion and Film is happy to be able to include the remarks of all the presenters here

How do practitioners perceive the relevance of requirements engineering research? An ongoing study

The relevance of Requirements Engineering (RE) research to practitioners is a prerequisite for problem-driven research in the area and key for a long-term dissemination of research results to everyday practice. To understand better how industry practitioners perceive the practical relevance of RE research, we have initiated the RE-Pract project, an international collaboration conducting an empirical study. This project opts for a replication of previous work done in two different domains and relies on survey research. To this end, we have designed a survey to be sent to several hundred industry practitioners at various companies around the world and ask them to rate their perceived practical relevance of the research described in a sample of 418 RE papers published between 2010 and 2015 at the RE, ICSE, FSE, ESEC/FSE, ESEM and REFSQ conferences. In this paper, we summarize our research protocol and present the current status of our study and the planned future steps.Peer ReviewedPostprint (author's final draft

GaMin’11 – an International Inter-laboratory Comparison for Geochemical CO2 - Saline Fluid - Mineral Interaction Experiments

Due to the strong interest in geochemical CO2-fluid-rock interaction in the context of geological storage of CO2 a growing number of research groups have used a variety of different experimental ways to identify important geochemical dissolution or precipitation reactions and – if possible – quantify the rates and extent of mineral or rock alteration. In this inter-laboratory comparison the gas-fluid-mineral reactions of three samples of rock-forming minerals have been investigated by 11 experimental labs. The reported results point to robust identification of the major processes in the experiments by most groups. The dissolution rates derived from the changes in composition of the aqueous phase are consistent overall, but the variation could be reduced by using similar corrections for changing parameters in the reaction cells over time. The comparison of experimental setups and procedures as well as of data corrections identified potential improvements for future gas-fluid-rock studies

How do practitioners perceive the relevance of Requirements Engineering research?

Context: The relevance of Requirements Engineering (RE) research to practitioners is vital for a long-term dissemination of research results to everyday practice. Some authors have speculated about a mismatch between research and practice in the RE discipline. However, there is not much evidence to support or refute this perception. Objective: This paper presents the results of a study aimed at gathering evidence from practitioners about their perception of the relevance of RE research and at understanding the factors that influence that perception. Method: We conducted a questionnaire-based survey of industry practitioners with expertise in RE. The participants rated the perceived relevance of 435 scientific papers presented at five top RE-related conferences. Results: The 153 participants provided a total of 2,164 ratings. The practitioners rated RE research as essential or worthwhile in a majority of cases. However, the percentage of non-positive ratings is still higher than we would like. Among the factors that affect the perception of relevance are the paper?s links to industry, the research method used, and respondents? roles. The reasons for positive perceptions were primarily related to the relevance of the problem and the soundness of the solution, while the causes for negative perceptions were more varied. The respondents also provided suggestions for future research, including topics researchers have studied for decades, like elicitation or requirement quality criteria. Conclusions: The study is valuable for both researchers and practitioners. Researchers can use the reasons respondents gave for positive and negative perceptions and the suggested research topics to help make their research more appealing to practitioners and thus more prone to industry adoption. Practitioners can benefit from the overall view of contemporary RE research by learning about research topics that they may not be familiar with, and compare their perception with those of their colleagues to self-assess their positioning towards more academic research.X. Franch’s work was partially supported by the Spanish project GENESIS TIN2016-79269-R. D. Mendez’ work was partially supported by the KKS foundation through the S.E.R.T. Research Profile project at Blekinge Institute of Technology. G.H. Travassos’ work is partically supported by CNPq (grant 304234/2018-4).Peer ReviewedPostprint (author's final draft

How do practitioners perceive the relevance of requirements engineering research? An ongoing study

The relevance of Requirements Engineering (RE) research to practitioners is a prerequisite for problem-driven research in the area and key for a long-term dissemination of research results to everyday practice. To understand better how industry practitioners perceive the practical relevance of RE research, we have initiated the RE-Pract project, an international collaboration conducting an empirical study. This project opts for a replication of previous work done in two different domains and relies on survey research. To this end, we have designed a survey to be sent to several hundred industry practitioners at various companies around the world and ask them to rate their perceived practical relevance of the research described in a sample of 418 RE papers published between 2010 and 2015 at the RE, ICSE, FSE, ESEC/FSE, ESEM and REFSQ conferences. In this paper, we summarize our research protocol and present the current status of our study and the planned future steps.Peer Reviewe

Continuous versus Intermittent Infusion of Vancomycin in Severe Staphylococcal Infections: Prospective Multicenter Randomized Study

A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections. A multicenter, prospective, randomized study was designed to compare CIV (targeted plateau drug serum concentrations of 20 to 25 mg/liter) and intermittent infusions of vancomycin (IIV; targeted trough drug serum concentrations of 10 to 15 mg/liter) in 119 critically ill patients with MRS infections (bacteremic infections, 35%; pneumonia, 45%). Microbiological and clinical outcomes, safety, pharmacokinetics, ease of treatment adjustment, and cost were compared. Microbiological and clinical outcomes and safety were similar. CIV patients reached the targeted concentrations faster (36 ± 31 versus 51 ± 39 h, P = 0.029) and fewer samples were required for treatment monitoring than with IIV patients (7.7 ± 2.2 versus 11.8 ± 3.9 per treatment, P < 0.0001). The variability between patients in both the area under the serum concentration-time curve (AUC(24h)) and the daily dose given over 10 days of treatment was lower with CIV than with IIV (variances, 14,621 versus 53,975 mg(2)/liter(2)/h(2) [P = 0.026] and 414 versus 818 g(2) [P = 0.057], respectively). The 10-day treatment cost per patient was $454 ± 137 in the IIV group and was 23$321 ± 81: P < 0.0001). In summary, for comparable efficacy and tolerance, CIV may be a cost-effective alternative to IIV