41 research outputs found
Perspectivas clásicas y modernas de las virtudes en la empresa (I)
Este cuaderno contiene: "La justicia como virtud global en Tomás de Aquino" "La virtud y el comercio en el pensamiento de Domingo de Soto: las prácticas comerciales, el carácter y el bien común" "La virtud en Kant" "Adam Smith y las virtudes burguesas en la competencia
AI is a viable alternative to high throughput screening: a 318-target study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
Relatório de estágio em farmácia comunitária
Relatório de estágio realizado no âmbito do Mestrado Integrado em Ciências Farmacêuticas, apresentado à Faculdade de Farmácia da Universidade de Coimbr
Perspectivas clásicas y modernas de las virtudes en la empresa (I)
Este cuaderno contiene: "La justicia como virtud global en Tomás de Aquino" "La virtud y el comercio en el pensamiento de Domingo de Soto: las prácticas comerciales, el carácter y el bien común" "La virtud en Kant" "Adam Smith y las virtudes burguesas en la competencia
Safe Handling of Hazardous Drugs: ASCO Standards.
PURPOSE: To provide 2019 ASCO standards on the safe handling of hazardous drugs.
METHODS: An Expert Panel was formed, and a systematic review of the literature on closed system transfer devices was performed to May 2017 using PubMed. The Cochrane Database of Systematic Reviews, PubMed, and Google Scholar were used to search for studies of medical surveillance and external ventilation/health effects of exposure to vapors to November 2017. Available standards were considered for endorsement. Public comments were solicited and considered in preparation of the final manuscript.
RESULTS: The search for primary research found no studies that addressed health outcomes as they relate to the identified interventions of interest. The ASCO Expert Panel endorses the best practices for safe handling of hazardous drugs as issued by the Occupational Safety and Health Administration, US Pharmacopeia Chapter 800, and Oncology Nursing Society with clarifications in four key areas: medical surveillance, closed system transfer devices, external ventilation of containment secondary engineering controls or containment segregated compounding areas, and alternative duties.
CONCLUSION: The ASCO standards address the need for clear standards concerning safe handling of hazardous oncology drugs. More research is needed in several key areas to quantify the level of risk associated with handling hazardous drugs in current workplace settings where the hierarchy of controls is consistently applied. Additional information is available at www.asco.org/safe-handling-standards
Preoperative Delirium Risk Screening in Patients Undergoing a Cardiac Surgery: Results from the Prospective Observational FINDERI Study
http://dx.doi.org/10.13039/501100005971 German Heart Foundatio
Capillarity-Driven Welding of Semiconductor Nanowires for Crystalline and Electrically Ohmic Junctions
Semiconductor
nanowires (NWs) have been demonstrated as a potential platform for
a wide-range of technologies, yet a method to interconnect functionally
encoded NWs has remained a challenge. Here, we report a simple capillarity-driven
and self-limited welding process that forms mechanically robust and
Ohmic inter-NW connections. The process occurs at the point-of-contact
between two NWs at temperatures 400–600 °C below the bulk
melting point of the semiconductor. It can be explained by capillarity-driven
surface diffusion, inducing a localized geometrical rearrangement
that reduces spatial curvature. The resulting weld comprises two fused
NWs separated by a single, Ohmic grain boundary. We expect the welding
mechanism to be generic for all types of NWs and to enable the development
of complex interconnected networks for neuromorphic computation, battery
and solar cell electrodes, and bioelectronic scaffolds