Land Grant Application- Libby, Thomas (Gorham)

Land grant application submitted to the Maine Land Office on behalf of Thomas Libby for service in the Revolutionary War, by their widow Mary.https://digitalmaine.com/revolutionary_war_me_land_office/1566/thumbnail.jp

First determination of the CPCP content of D→π+π−π+π−D \to \pi^+\pi^-\pi^+\pi^- and updated determination of the CPCP contents of D→π+π−π0D \to \pi^+\pi^-\pi^0 and D→K+K−π0D \to K^+K^-\pi^0

Quantum-correlated $\psi(3770) \to D\bar{D}$ decays collected by the CLEO-c experiment are used to perform a first measurement of $F_+^{4\pi}$, the fractional $CP$-even content of the self-conjugate decay $D \to \pi^+\pi^-\pi^+\pi^-$, obtaining a value of $0.737 \pm 0.028$. An important input to the measurement comes from the use of $D \to K^0_{\rm S}\pi^+\pi^-$ and $D \to K^0_{\rm L}\pi^+\pi^-$ decays to tag the signal mode. This same technique is applied to the channels $D \to\pi^+\pi^-\pi^0$ and $D \to K^+K^-\pi^0$, yielding $F_+^{\pi\pi\pi^0} = 1.014 \pm 0.045 \pm 0.022$ and $F_+^{KK\pi^0} = 0.734 \pm 0.106 \pm 0.054$, where the first uncertainty is statistical and the second systematic. These measurements are consistent with those of an earlier analysis, based on $CP$-eigenstate tags, and can be combined to give values of $F_+^{\pi\pi\pi^0} = 0.973 \pm 0.017$ and $F_+^{KK\pi^0} = 0.732 \pm 0.055$. The results will enable the three modes to be included in a model-independent manner in measurements of the unitarity triangle angle $\gamma$ using $B^\mp \to DK^\mp$ decays, and in time-dependent studies of $CP$ violation and mixing in the $D\bar{D}$ system.Comment: Minor revisions following journal acceptanc

A CLINICAL, RADIOLOGICAL AND IL-6 EVALUATION OF SUBGINGIVALLY DELIVERED SIMVASTATIN IN THE TREATMENT OF CHRONIC PERIODONTITIS

Simvastatin (SMV) are specific competitive inhibitors which are widely used to lower cholesterol for the treatment of hyperlipidemia and arteriosclerosis. They have shown to modulate bone formation by increasing the expression of bone morphogenetic protein-2, inflammation, and angiogenesis,3 thus providing a new direction in the field of periodontal therapy. The aim of this randomized trial was to assess the clinical and radiographic effects of 1.2% Simvastatin  gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis. The IL-6 level in the sulcular epithelium was also evaluated before and after treatment with 1.2% simvastatin. 60 sites were selected with minimum one intrabony defect and probing pocket depth of >5mm and were divided into 2 groups; 30 sites were treated with SRP and placebo (Group A) and 30 sites were treated with SRP along with Simvastatin (SMV) (group B). Clinical parameters recorded at baseline before SRP and at 60th, 90th and 180th day; included plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD), and clinical attachment level (CAL). Radiologic assessment of intrabony defect (IBD) fill was done at baseline and after 6 months using computer-aided software. Interleukin-6-mRNA (IL-6-mRNA) levels in sulcular epithelium was analysed for Group B at baseline and 3 months after the drug application. Both therapies resulted in significant improvements in the parameters however SRP along with simvastatin showed statistically significant decrease in PI, mSBI and PD and gain in CAL at 6 months. In Group B, there was greater decrease in mean IBD as compared to Group A. At the molecular level the simvastatin group showed a significant decrease in IL-6-mRNA levels. The statistically significant improvement in clinical and hard tissue parameters at sites treated with SRP plus locally delivered SMV as well as its potency in reducing IL-6-mRNA levels proved the efficacy of  the drug as a local drug delivery system in the treatment of chronic periodontitis not only in clinical but as well as in molecular level

Comparative Design, Scaling, and Control of Appendages for Inertial Reorientation

This paper develops a comparative framework for the design of an actuated inertial appendage for planar reorientation. We define the Inertial Reorientation template, the simplest model of this behavior, and leverage its linear dynamics to reveal the design constraints linking a task with the body designs capable of completing it. As practicable inertial appendage designs lead to physical bodies that are generally more complex, we advance a notion of “anchoring” whereby a judicious choice of physical design in concert with an appropriate control policy yields a system whose closed loop dynamics are sufficiently captured by the template as to permit all further design to take place in its far simpler parameter space. This approach is effective and accurate over the diverse design spaces afforded by existing platforms, enabling performance comparison through the shared task space. We analyze examples from the literature and find advantages to each body type, but conclude that tails provide the highest potential performance for reasonable designs. Thus motivated, we build a physical example by retrofitting a tail to a RHex robot and present empirical evidence of its efficacy. For more information: Kod*la