Formal Controller Synthesis for Markov Jump Linear Systems with Uncertain Dynamics

Automated synthesis of provably correct controllers for cyber-physical systems is crucial for deployment in safety-critical scenarios. However, hybrid features and stochastic or unknown behaviours make this problem challenging. We propose a method for synthesising controllers for Markov jump linear systems (MJLSs), a class of discrete-time models for cyber-physical systems, so that they certifiably satisfy probabilistic computation tree logic (PCTL) formulae. An MJLS consists of a finite set of stochastic linear dynamics and discrete jumps between these dynamics that are governed by a Markov decision process (MDP). We consider the cases where the transition probabilities of this MDP are either known up to an interval or completely unknown. Our approach is based on a finite-state abstraction that captures both the discrete (mode-jumping) and continuous (stochastic linear) behaviour of the MJLS. We formalise this abstraction as an interval MDP (iMDP) for which we compute intervals of transition probabilities using sampling techniques from the so-called 'scenario approach', resulting in a probabilistically sound approximation. We apply our method to multiple realistic benchmark problems, in particular, a temperature control and an aerial vehicle delivery problem.Comment: 14 pages, 6 figures, under review at QES

A Review of Numerical Models for Slab-Asphalt Track Railways

Higher train speeds and heavier axle loads trigger elevated stresses and vibrations in the track, potentially increasing track deterioration rates and maintenance costs. Alternative track forms made of combinations of reinforced concrete and asphalt layers have been developed. A thorough understanding of the slab and asphalt tracks is needed to investigate track performance. Thus, analytical and numerical models have been developed and validated by many researchers. This paper reviews numerical models developed to investigate railway track performance. The synthesis of major finite element models is described in detail, highlighting the main components and their outputs. For slab track models, the use of a structural asphalt layer within the railway track remains an active research topic and firm conclusions on its efficacy are not yet available. It can be expected that slab track structures will also be affected by train-induced ground vibrations. There is thus a gap in the literature regarding the measurement of dynamic effects on high-speed railway lines, and further research is needed to investigate the dynamic behaviour of slab–asphalt track systems. In this review, novel solutions for mitigating the vibrations in high-speed rail are discussed and compared. The use of asphalt material in railways appears to have beneficial effects, such as increasing the bearing capacity and stiffness of the structure and improving its dynamic performance and responses, particularly under high-speed train loads

Effects of Doxorubicin on Extracellular Matrix Regulation in Primary Cardiac Fibroblasts from Mice

Objective Doxorubicin (DOX) is a highly effective chemotherapeutic used to treat many adult and pediatric cancers. However, its use is limited due to a dose-dependent cardiotoxicity, which can lead to lethal cardiomyopathy. In contrast to the extensive research efforts on toxic effects of DOX in cardiomyocytes, its effects and mechanisms on cardiac extracellular matrix (ECM) homeostasis and remodeling are poorly understood. In this study, we examined the potential effects of DOX on cardiac ECM to further our mechanistic understanding of DOX-induced cardiotoxicity. Results DOX-induced significant down-regulation of several ECM related genes in primary cardiac fibroblasts, including Adamts1, Adamts5, Col4a1, Col4a2, Col5a1, Fbln1, Lama2, Mmp11, Mmp14, Postn, and TGFβ. Quantitative proteomics analysis revealed significant global changes in the fibroblast proteome following DOX treatment. A pathway analysis using iPathwayGuide of the differentially expressed proteins revealed changes in a list of biological pathways that involve cell adhesion, cytotoxicity, and inflammation. An apparent increase in Picrosirius red staining indicated that DOX-induced an increase in collagen production in cardiac primary fibroblasts after 3-day treatment. No significant changes in collagen organization nor glycoprotein production were observed

Implementing and Measuring KEMTLS

KEMTLS is a novel alternative to the Transport Layer Security (TLS) handshake that integrates post-quantum algorithms. It uses key encapsulation mechanisms (KEMs) for both confidentiality and authentication, achieving post-quantum security while obviating the need for expensive post-quantum signatures. The original KEMTLS paper presents a security analysis, Rust implementation, and benchmarks over emulated networks. In this work, we provide full Go implementations of KEMTLS and other post-quantum handshake alternatives, describe their integration into a distributed system, and provide performance evaluations over real network conditions. We compare the standard (nonquantum-resistant) TLS 1.3 handshake with three alternatives: one that uses post-quantum signatures in combination with post-quantum KEMs (PQTLS), one that uses KEMTLS, and one that is a reduced round trip version of KEMTLS (KEMTLS-PDK). In addition to the performance evaluations, we discuss how the design of these protocols impacts TLS from an implementation and configuration perspective

Volumetric and microstructural abnormalities of the amygdala in focal epilepsy with varied levels of SUDEP risk

Although the mechanisms of sudden unexpected death in epilepsy (SUDEP) are not yet well understood, generalised- or focal-to-bilateral tonic-clonic seizures (TCS) are a major risk factor. Previous studies highlighted alterations in structures linked to cardio-respiratory regulation; one structure, the amygdala, was enlarged in people at high risk of SUDEP and those who subsequently died. We investigated volume changes and the microstructure of the amygdala in people with epilepsy at varied risk for SUDEP since that structure can play a key role in triggering apnea and mediating blood pressure. The study included 53 healthy subjects and 143 patients with epilepsy, the latter separated into two groups according to whether TCS occur in years before scan. We used amygdala volumetry, derived from structural MRI, and tissue microstructure, derived from diffusion MRI, to identify differences between the groups. The diffusion metrics were obtained by fitting diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) models. The analyses were performed at the whole amygdala level and at the scale of amygdaloid nuclei. Patients with epilepsy showed larger amygdala volumes and lower neurite density indices (NDI) than healthy subjects; the left amygdala volumes were especially enhanced. Microstructural changes, reflected by NDI differences, were more prominent on the left side and localized in the lateral, basal, central, accessory basal and paralaminar amygdala nuclei; basolateral NDI lowering appeared bilaterally. No significant microstructural differences appeared between epilepsy patients with and without current TCS. The central amygdala nuclei, with prominent interactions from surrounding nuclei of that structure, project to cardiovascular regions and respiratory phase switching areas of the parabrachial pons, as well as to the periaqueductal gray. Consequently, they have the potential to modify blood pressure and heart rate, and induce sustained apnea or apneusis. The findings here suggest that lowered NDI, indicative of reduced dendritic density, could reflect an impaired structural organization influencing descending inputs that modulate vital respiratory timing and drive sites and areas critical for blood pressure control

TRY plant trait database – enhanced coverage and open access

Plant traits - the morphological, anatomical, physiological, biochemical and phenological characteristics of plants - determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait‐based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits - almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives

Using Adobe XD to collaborate with peers

This project helps students to create a collaborative XD file to provide a space to collaborate and work with their peers on projects. It teaches students how to integrate modular plugins with Adobe XD to create presentations, mock-ups and whiteboard. Students will develop their knowledge in Adobe XD using this project instruction resource to help them maximise Adobe XD for collaboration and teamwork