27 research outputs found
Does HIV adversely influence the outcome in advanced non-small-cell lung cancer in the era of HAART?
Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK Biobank
This is the author accepted manuscriptData availability:
All data in this project was part of the UK Biobank resource and was accessed under application number 74981. Information on how to access the UK Biobank can be found at https://www.ukbiobank.ac.uk/enable-your-research/apply-for-accessCode availability:
All code used to generate results for this study can be found at the author’s Github page: https://github.com/hdg204/ProstateCancerBackground
Prostate cancer is highly heritable, with >250 common variants associated in genome-wide association studies. It commonly presents with non-specific lower urinary tract symptoms that are frequently associated with benign conditions.
Methods
Cohort study using UK Biobank data linked to primary care records. Participants were men with a record showing a general practice consultation for a lower urinary tract symptom. The outcome measure was prostate cancer diagnosis within two years of consultation. The predictor was a genetic risk score of 269 genetic variants for prostate cancer.
Results
A genetic risk score (GRS) is associated with prostate cancer in symptomatic men (OR per SD increase=2.12 [1.86 to 2.41] p=3.5e-30). An integrated risk model including age and GRS applied to symptomatic men predicted prostate cancer (AUC 0.768 [0.739 to 0.796]). Prostate cancer incidence was 8.1% (6.7 to 9.7) in the highest risk quintile. In the lowest quintile, prostate cancer incidence was <1%.
Conclusions
This study is the first to apply GRS in primary care to improve the triage of symptomatic patients. Men with the lowest genetic risk of developing prostate cancer could safely avoid invasive investigation, whilst those identified with the greatest risk could be fast-tracked for further investigation. These results show that a GRS has potential application to improve the diagnostic pathway of symptomatic patients in primary care.Philanthropic Donatio