Digital Literacy: A Demand for Nonlinear Thinking Styles

This paper makes a case for a direct relationship between digital literacy and nonlinear thinking styles, articulates a demand for nonlinear thinking styles in education and the workplace, and states implications for a connection between nonlinear thinking styles visual literacy, and intuitive artistic practice

Antimicrobial potent (E)-2-(1-phenylethylidene)-1-tosylhydrazines

399-405A series containing ten (E)-2-(1-phenylethylidene)-1-tosylhydrazines have been synthesized by thionyl chloride catalyst assisted condensation between 1-tosylhydrazine and substituted acetophenones. These benzylidenes have been characterized by their physical constants, UV-Vis, IR, 1H and 13C NMR spectral techniques. The antibacterial and antifungal activities of the synthesized benzylidene have been evaluated

MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR

The Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded chemokine receptor vGPCR acts as an oncogene in Kaposi's sarcomagenesis. Until now, the molecular mechanisms by which the vGPCR contributes to tumor development remain incompletely understood. Here, we show that the KSHV-vGPCR contributes to tumor progression through microRNA (miR)-34a-mediated induction of genomic instability. Large-scale analyses on the DNA, gene and protein level of cell lines derived from a mouse model of vGPCR-driven tumorigenesis revealed that a vGPCR-induced upregulation of miR-34a resulted in a broad suppression of genome maintenance genes. A knockdown of either the vGPCR or miR-34a largely restored the expression of these genes and confirmed miR-34a as a downstream effector of the KSHV-vGPCR that compromises genome maintenance mechanisms. This novel, protumorigenic role of miR-34a questions the use of miR-34a mimetics in cancer therapy as they could impair genome stability

Effect of substituents on phenazine derivatives by spectral studies

C NMR spectral data of prepared phenazines were correlated with Hammett substituent constants, F and R parameters using single and multi-regression analysis. From the results of statistical analysis, the effect of substituents on the infrared frequencies (ν, cm -1 ) and 13 C nmr chemical shifts(δ, ppm) has been studied

A Heterogeneous, Highly Efficient, and Reusable Mo-Al2O3 Composites Based Organocatalyst for One Pot Three-Component Mannich Reaction for the Synthesis of β-aminocarbonyl Compounds

We have successfully developed a new Mo-Al2O3/p-TSA organocatalyst which has improved the yield of the Mannich reaction. This protocol has the advantage of mild conditions, high yield, easy work-up, environmentally friendly procedure, and the solid catalyst was recycled. The catalyst was analysed by XRD, SEM, and EDS techniques. The synthesized Mo-Al2O3composites were used in the presence of p-toluene sulfonic acid (p-TSA) conducts the one-pot three-component Mannich reaction and various β-amino ketones prepared with good yields and characterized by IR, 1H, and 13C NMR Techniques

Synthesis, spectral, antibacterial and docking analyses of (3,4-bis((E)-(arylidene)amino)phenyl)(phenyl)methanones

Biologically active Schiff bases namely (3,4-bis((E)-(arylidene)amino) phenyl)(phenyl)methanones have been synthesized through ultrasonicated condensation of (3,4-diaminophenyl)(phenyl)methanone and various benzaldehydes in ethanol medium. Synthesised Schiff bases have been examined by different techniques like molecular formula calculation, molecular weight determination, melting point determination, micro analysis and spectroscopic data. The in vitro antibacterial actions of these E-imines have been assessed against bacterial strains by zone inhibition and serial dilution methods. Further, molecular docking analysis of all E-imines have been accomplished to comprehend the order of binding of Schiff bases with protein

Ultrasonicated synthesis of some potent antimicrobial aryl sulphonamides

1373-1377Nine N-(2,4-difluorophenyl) substituted benzene sulphonamides have been synthesized by ultrasonication method within short reaction time having more than 90% yield. These sulphonamides have been analyzed by spectral and analytical techniques. The higher yields of sulphonamides have been found to be in case of ultrasonication process as compared to microwave and conventional heating methods. The antimicrobial activities of these sulphonamides have been evaluated using Bauer-Kirby disc diffusion method by means of measurement of mm of zone of inhibition

Student Satisfaction and Performance in an Online Teacher Certification Program

The article presents a study which demonstrates the effectiveness of an online post baccalaureate teacher certification program developed by a Wisconsin university. The case method approach employing multiple methods and multiple data sources were used to investigate the degree to which pre-service teachers were prepared to teach. It was concluded that the study supports online delivery as an effective means of teacher preparation, but it was limited in the number of students followed into their first year of teaching