575 research outputs found
Analytical solution of the Gross-Neveu model at finite density
Recent numerical calculations have shown that the ground state of the
Gross-Neveu model at finite density is a crystal. Guided by these results, we
can now present the analytical solution to this problem in terms of elliptic
functions. The scalar potential is the superpotential of the non-relativistic
Lame Hamiltonian. This model can also serve as analytically solvable toy model
for a relativistic superconductor in the Larkin-Ovchinnikov-Fulde-Ferrell
phase.Comment: 5 pages, no figures, revtex; vs2: appendix with analytical proof of
self-consistency adde
Parathyroid localization
Twenty-nine consecutive patients with suspected primary hyperparathyroidism were examined preoperatively using ultrasound, sonographically guided fine needle aspiration, and aspirate immunostaining for PTH. In 25 patients, localization of enlarged parathyroid glands was successful. In 2 patients, the tumors were located retrosternally and, thus, could not be detected by ultrasound. One patient had a multinodular goiter which impeded localization. In 1 patient with renal osteodystrophy, 2 enlarged parathyroid glands in the neck were not visualized preoperatively. Cytology was not diagnostic, although some cytological features were suggestive of parathyroid cells. Immunostaining of the aspirated smears for PTH, however, correctly diagnosed all preoperatively localized lesions. Ultrasound should be the routine procedure of choice for preoperative localization of abnormal parathyroid glands in primary hyperparathyroidism. Fine needle aspiration and immunocytochemistry can supply confirmation, if necessary
Lectin binding to cutaneous malignant melanoma: HPA is associated with metastasis formation
Changes in protein glycosylation of tumour cells, as detected by lectin histochemistry, have been associated with metastasis formation in several human malignancies. This study analysed the association between lectin binding and metastasis in cutaneous malignant melanoma. In a 10-year retrospective study, sections of 100 primary cutaneous malignant melanomas were histochemically stained for the following 5 lectins: HPA, SNA-I, MAA, WGA and PHA-L, differing in their carbohydrate specificity. Since differences in the results of HPA binding depending on methodology have been reported, an indirect and a biotinylated method were employed for HPA. KaplanâMeier analysis of time to first metastasis revealed a positive correlation between HPA binding and metastasis for both methods, with the biotinylated HPA method (P< 0.0001) being superior to the âindirectâ method (P = 0.0006). Cox regression analysis demonstrated that even after adjustment for stage, HPA positivity is an independent predictor for metastasis. The results of the present study indicate that N -acetyl-galactosamine/-glucosamine residues, recognized by HPA, are linked to metastasis in malignant melanoma. In contrast, ÎČ1-6 branched oligosaccharides or sialic acid residues, both of which were correlated with metastasis in other malignancies, are of no functional importance for metastasis formation in malignant melanoma. Thus, HPA proved to be a useful and independent prognostic marker for the metastatic phenotype of melanoma. © 2001 Cancer Research Campaign http://www.bjcancer.co
Objective measures of rollator user stability and device loading during different walking scenarios
Walking aids are widely used by older adults, however, alarmingly, their use has been linked to increased falls-risk, yet clinicians have no objective way of assessing user stability. This work aims to demonstrate the application of a novel methodology to investigate how the type of walking task, the amount of body weight supported by the device (i.e., device loading), and task performance strategy affect stability of rollator users. In this context, ten users performed six walking tasks with an instrumented rollator. The combined stability margin âSMâ was calculated, which considers user and rollator as a combined system. A Friedman Test was used to investigate the effects of task on SM and a least-squares regression model was applied to investigate the relationship between device loading and SM. In addition, the effects of task performance strategy on SM were explored. As a result, it was found that: the minimum SM for straight line walking was higher than for more complex tasks (p<0.05); an increase in device loading was associated with an increase in SM (p<0.05); stepping up a kerb with at least 1 rollator wheel in ground contact at all times resulted in higher SM than lifting all four wheels simultaneously. Hence, we conclude that training should not be limited to straight line walking but should include various everyday tasks. Within person, SM informs on which tasks need practicing, and which strategy facilitates stability, thereby enabling person-specific guidance/training. The relevance of this work lies in an increase in walking aid users, and the costs arising from fall-related injuries.
Supplementary data is available in Figshare
Revised Phase Diagram of the Gross-Neveu Model
We confirm earlier hints that the conventional phase diagram of the discrete
chiral Gross-Neveu model in the large N limit is deficient at non-zero chemical
potential. We present the corrected phase diagram constructed in mean field
theory. It has three different phases, including a kink-antikink crystal phase.
All transitions are second order. The driving mechanism for the new structure
of baryonic matter in the Gross-Neveu model is an Overhauser type instability
with gap formation at the Fermi surface.Comment: Revtex, 12 pages, 15 figures; v2: Axis labelling in Fig. 9 correcte
Dimensional Reduction of Fermions in Brane Worlds of the Gross-Neveu Model
We study the dimensional reduction of fermions, both in the symmetric and in
the broken phase of the 3-d Gross-Neveu model at large N. In particular, in the
broken phase we construct an exact solution for a stable brane world consisting
of a domain wall and an anti-wall. A left-handed 2-d fermion localized on the
domain wall and a right-handed fermion localized on the anti-wall communicate
with each other through the 3-d bulk. In this way they are bound together to
form a Dirac fermion of mass m. As a consequence of asymptotic freedom of the
2-d Gross-Neveu model, the 2-d correlation length \xi = 1/m increases
exponentially with the brane separation. Hence, from the low-energy point of
view of a 2-d observer, the separation of the branes appears very small and the
world becomes indistinguishable from a 2-d space-time. Our toy model provides a
mechanism for brane stabilization: branes made of fermions may be stable due to
their baryon asymmetry. Ironically, our brane world is stable only if it has an
extreme baryon asymmetry with all states in this ``world'' being completely
filled.Comment: 26 pages, 7 figure
Low-dose mistletoe lectin-I reduces melanoma growth and spread in a scid mouse xenograft model
This study investigates the effects of mistletoe lectin-I (ML-I) on melanoma growth and spread in vivo. The human melanoma cell line MV3 was xenografted into severe combined immunodeficient mice and vehicle solution or purified ML-I was administered at 30, 150 and 500âng per kg body weight (20 mice per group) daily. After 19 days, mice were killed, primary tumours (PTs) and lungs were dissected out, and tumour weights, number of lung metastases (LMs), number of tumour-infiltrating dendritic cells (DCs), and apoptosis rates in the melanoma cells and in the DCs were assessed. A 35% reduction of PT weight (P=0.03) and a 55% decrease in number of LMs (P=0.016) were evident for low-dose ML-I (30ângâkgâ1) treatment but not for higher doses. Mistletoe lectin-I increased apoptosis rates in the melanoma cells of PTs at all doses, while no induction of apoptosis was noted in the LMs. Low-dose ML-I significantly increased the number of DCs infiltrating the PTs (P<0.0001) and protected DCs against apoptosis, while higher doses induced apoptosis in the DCs (P<0.01). Our results demonstrate that low-dose ML-I reduced melanoma growth and number of metastases in vivo, primarily due to immunomodulatory effects
No First-Order Phase Transition in the Gross-Neveu Model?
Within a variational calculation we investigate the role of baryons for the
structure of dense matter in the Gross-Neveu model. We construct a trial ground
state at finite baryon density which breaks translational invariance. Its
scalar potential interpolates between widely spaced kinks and antikinks at low
density and the value zero at infinite density. Its energy is lower than the
one of the standard Fermi gas at all densities considered. This suggests that
the discrete gamma_5 symmetry of the Gross-Neveu model does not get restored in
a first order phase transition at finite density, at variance with common
wisdom.Comment: 16 pages, 7 figures, LaTe
Scaling percentages and distributional patterns of benthic foraminifera with flux rates of organic carbon
Seafloor organic matter flux from marine primary productivity is quantified, and the range of annual flux rates is calculated and compared to the counts of benthic foraminifera at 382 surface sediment stations from the equatorial Guinea Basin to the Arctic Ocean. Benthic foraminifera show high variability in flux range dependent distributional patterns, with maximum deviations at lowest percentages. The occurrence of a single species covers flux ranges within one to three orders of magnitude. Only a small number of species shows a correlation of this broad range of organic fluxes versus percentages in a count. For C. wuellerstorfi a functional relationship for the recalculation of flux rates from percentages in a count can be given within a standard deviation below 2 g organic carbon [m 2 yr 1]. However, such functions have to be restricted to a specific size range counted. The patterns of dominance more closely scale the environmental optimum of the species in general. For interspecific combinations, these patterns identify the ranges of overlap, where it is impossible to distinguish between higher or lower fluxes on the basis of faunal composition. This is quantified for the co-occurrence of C. wuellerstorfi and U. peregrina near 20% for one species. On an ocean wide scale, a number of taxa can be used to define threshold values for the nutritive needs of the assemblages, most pronounced within annual flux ranges at 2-3 g org. C [m-2]. Different trophic needs of species can be attributed to their infaunal, epibenthic, or opportunistic behavior respectively, and examples for the flux dependent takeover in dominance are given. These quantifications may offer approximations for flux rate dependent faunal patterns in surface sediments and for the detection of flux rate dependent faunal fluctuations in the Quaternary record
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