Multiple Thresholds in a Model System of Noisy Ion Channels

Voltage-activated ion channels vary randomly between open and closed states, influenced by the membrane potential and other factors. Signal transduction is enhanced by noise in a simple ion channel model. The enhancement occurs in a finite range of signals; the range can be extended using populations of channels. The range increases more rapidly in multiple-threshold channel populations than in single-threshold populations. The diversity of ion channels may thus be present as a strategy to reduce the metabolic costs of handling a broad class of electrochemical signals.Comment: REVTeX 4, 5 pages, 4 figures; added paragrap

Symbol of Turkish modernity and Bastion of the West: the Hilton Hotel in İstanbul

Middle Eastern Studie

The Missing Margin: How Sample Corruption Affects Distance to the Boundary in ANNs

Classification margins are commonly used to estimate the generalization ability of machine learning models. We present an empirical study of these margins in artificial neural networks. A global estimate of margin size is usually used in the literature. In this work, we point out seldom considered nuances regarding classification margins. Notably, we demonstrate that some types of training samples are modelled with consistently small margins while affecting generalization in different ways. By showing a link with the minimum distance to a different-target sample and the remoteness of samples from one another, we provide a plausible explanation for this observation. We support our findings with an analysis of fully-connected networks trained on noise-corrupted MNIST data, as well as convolutional networks trained on noise-corrupted CIFAR10 data.Comment: This work is a preprint of a published paper by the same name, which it subsumes. This preprint is an extended version: it contains additional empirical evidence and discussio

Reconfigurable contour beam synthesis using a mechanical FEM surface description of dual offset reflector antenna surfaces

No abstract availableThesis (PhD (Electronic Engineering))--University of Pretoria, 2007.Electrical, Electronic and Computer Engineeringunrestricte

The early identification of risk factors on the pathway to school dropout in the SIODO study:A sequential mixed-methods study

BACKGROUND: School dropout is a persisting problem with major socioeconomic consequences. Although poor health probably contributes to pathways leading to school dropout and health is likely negatively affected by dropout, these issues are relatively absent on the public health agenda. This emphasises the importance of integrative research aimed at identifying children at risk for school dropout at an early stage, discovering how socioeconomic status and gender affect health-related pathways that lead to dropout and developing a prevention tool that can be used in public health services for youth. METHODS/DESIGN: The SIODO study is a sequential mixed-methods study. A case–control study will be conducted among 18 to 24 year olds in the south of the Netherlands (n = 580). Data are currently being collected from compulsory education departments at municipalities (dropout data), regional public health services (developmental data from birth onwards) and an additional questionnaire has been sent to participants (e.g. personality data). Advanced analyses, including cluster and factor analyses, will be used to identify children at risk at an early stage. Using the quantitative data, we have planned individual interviews with participants and focus groups with important stakeholders such as parents, teachers and public health professionals. A thematic content analysis will be used to analyse the qualitative data. DISCUSSION: The SIODO study will use a life-course perspective, the ICF-CY model to group the determinants and a mixed-methods design. In this respect, the SIODO study is innovative because it both broadens and deepens the study of health-related determinants of school dropout. It examines how these determinants contribute to socioeconomic and gender differences in health and contributes to the development of a tool that can be used in public health practice to tackle the problem of school dropout at its roots

Vortex lattices in strong type-II superconducting two-dimensional strips

We show how to calculate semi-analytically the dense vortex state in strong type-II superconducting nanostructures. For the specific case of a strip, we find vortex lattice solutions which also incorporate surface superconductivity. We calculate the energy cost to displace individual vortex rows parallel to the surfaces and find that this energy oscillates with the magnetic field. Remarkably, we also find that, at a critical field $H^*$ below $H_{c2}$, this ''shear'' energy becomes strictly zero for the surface rows due to an unexpected mismatch with the bulk lattice.Comment: Title, abstract, and some text paragraphs have been rewritte

Effect of Pulsed or Continuous Delivery of Salt on Sensory Perception Over Short Time Intervals

Salt in the human diet is a major risk factor for hypertension and many countries have set targets to reduce salt consumption. Technological solutions are being sought to lower the salt content of processed foods without altering their taste. In this study, the approach was to deliver salt solutions in pulses of different concentrations to determine whether a pulsed delivery profile affected sensory perception of salt. Nine different salt profiles were delivered by a Dynataste device and a trained panel assessed their saltiness using time–intensity and single-score sensory techniques. The profile duration (15 s) was designed to match eating conditions and the effects of intensity and duration of the pulses on sensory perception were investigated. Sensory results from the profiles delivered in either water or in a bouillon base were not statistically different. Maximum perceived salt intensities and the area under the time– intensity curves correlated well with the overall perceived saltiness intensity despite the stimulus being delivered as several pulses. The overall saltiness scores for profiles delivering the same overall amount of sodium were statistically not different from one another suggesting that, in this system, pulsed delivery did not enhance salt perception but the overall amount of salt delivered in each profile did affect sensory perception

Nonlocal Conductivity in the Vortex-Liquid Regime of a Two-Dimensional Superconductor

We have simulated the time-dependent Ginzburg-Landau equation with thermal fluctuations, to study the nonlocal dc conductivity of a superconducting film. Having examined points in the phase diagram at a wide range of temperatures and fields below the mean-field upper critical field, we find a portion of the vortex-liquid regime in which the nonlocal ohmic conductivity in real space is negative over a distance several times the spacing between vortices. The effect is suppressed when driven beyond linear response. Earlier work had predicted the existence of such a regime, due to the high viscosity of a strongly-correlated vortex liquid. This behavior is clearly distinguishable from the monotonic spatial fall-off of the conductivity in the higher temperature or field regimes approaching the normal state. The possibilities for experimental study of the nonlocal transport properties are discussed.Comment: 18 pages, revtex, 6 postscript figure

Influence of temperature and relative humidity on the survival of <i>Chlamydia pneumoniae</i> in aerosols

The survival of Chlamydia pneumoniae in aerosols was investigated by using a chamber with a capacity of 114.5 liters. We injected 5 x 107 inclusion- forming units (IFU) of C. pneumoniae in aerosols with a droplet size of 3 to 5 μm. Samples were taken after 30 s and every 1 min thereafter. The survival of C. pneumoniae was measured at four temperatures (8.5, 15, 25, and 35°C) and at three different relative humidities (RH) of 5, 50, and 95% for each temperature. The survival rates of Streptococcus pneumoniae, Streptococcus faecalis, Klebsiella pneumoniae, Chlamydia trachomatis LGV2, and cytomegalovirus were also determined at 25°C and 95% RH and compared with that of C. pneumoniae. At the mentioned temperatures and RH, a rapid decrease of C. pneumoniae IFU was observed in the first 30 s. After this the decrease in the number of IFU was more gradual. The survival of C. pneumoniae in aerosols was optimal at 15 to 25°C and 95% RH; it was good compared with those of other microorganisms. A lower death rate was observed only in S. faecalis. In C. trachomatis, the death rate during the first 30 s was higher than that in C. pneumoniae (85 and 53.3%, respectively). After the first 30 s, the death rates in the two organisms were identical. It was concluded that transmission of C. pneumoniae via aerosols was possible. There is probably a direct transmission from person to person, taking into account the relatively short survival period of C. pneumoniae in aerosols.</p