Contextual Simulated Annealing Q-Learning for Pre-negotiation of Agent-Based Bilateral Negotiations

Electricity markets are complex environments, which have been suffering continuous transformations due to the increase of renewable based generation and the introduction of new players in the system. In this context, players are forced to re-think their behavior and learn how to act in this dynamic environment in order to get as much benefit as possible from market negotiations. This paper introduces a new learning model to enable players identifying the expected prices of future bilateral agreements, as a way to improve the decision-making process in deciding the opponent players to approach for actual negotiations. The proposed model introduces a con-textual dimension in the well-known Q-Learning algorithm, and includes a simulated annealing process to accelerate the convergence process. The proposed model is integrated in a multi-agent decision support system for electricity market players negotiations, enabling the experimentation of results using real data from the Iberian electricity market.This work has received funding from the European Union's Horizon 2020 research and innovation programme under project DOMINOES (grant agreement No 771066) and from FEDER Funds through COMPETE program and from National Funds through FCT under the project UID/EEA/00760/2019.info:eu-repo/semantics/publishedVersio

Neurotensin Receptor 1 Is Expressed in Gastrointestinal Stromal Tumors but Not in Interstitial Cells of Cajal

Gastrointestinal stromal tumors (GIST) are thought to derive from the interstitial cells of Cajal (ICC) or an ICC precursor. Oncogenic mutations of the KIT or PDGFRA receptor tyrosine kinases are present in the majority of GIST, leading to ligand-independent activation of the intracellular signal transduction pathways. We previously investigated the gene expression profile in the murine KitK641E GIST model and identified Ntsr1 mRNA, encoding the Neurotensin receptor 1, amongst the upregulated genes. Here we characterized Ntsr1 mRNA and protein expression in the murine KitK641E GIST model and in tissue microarrays of human GIST. Ntsr1 mRNA upregulation in KitK641E animals was confirmed by quantitative PCR. Ntsr1 immunoreactivity was not detected in the Kit positive ICC of WT mice, but was present in the Kit positive hyperplasia of KitK641E mice. In the normal human gut, NTSR1 immunoreactivity was detected in myenteric neurons but not in KIT positive ICC. Two independent tissue microarrays, including a total of 97 GIST, revealed NTSR1 immunoreactivity in all specimens, including the KIT negative GIST with PDGFRA mutation. NTSR1 immunoreactivity exhibited nuclear, cytoplasmic or mixed patterns, which might relate to variable levels of NTSR1 activation. As studies using radio-labeled NTSR1 ligand analogues for whole body tumor imaging and for targeted therapeutic interventions have already been reported, this study opens new perspectives for similar approaches in GIST