6 research outputs found
Colorimetric Determination of Cefadroxil and Ceftriazone in Pharmaceutical Dosage Forms
Purpose: To develop a simple, rapid and selective method for the spectrophotometric determination of cefadroxil and ceftriaxone using 1, 2- napthaquinone-4- sulfonic acid sodium.Methods: The method was based on the derivatization of cefadroxil and ceftriaxone with 1, 2-naphthaquinone-4- sulfonic acid sodium in alkaline medium to yield orange-colored products.Results: The reaction products of cefadroxil and ceftriaxone at their respective max of 475 and 480 nm showed linearity in the concentration range of 10 - 100 and 25 - 175 Ïg/ml, respectively. Relative standard deviations of 0.82 % for cefadroxil and 0.95 % for ceftriaxone were obtained. Recoveries of cefadroxil tablets and ceftriaxone injection were in the range of 100.66 ± 0.98 and 99.38 ± 0.84 %, respectively.Conclusion: Recovery studies gave satisfactory results indicating that none of the major additives/excipients interfered with the assay method. Therefore, the proposed method is simple, rapid, precise and convenient for the assay of cefadroxil and ceftriaxone in commercial preparations
Colorimetric Determination of Cefadroxil and Ceftriazone in Pharmaceutical Dosage Forms
Purpose: To develop a simple, rapid and selective method for the
spectrophotometric determination of cefadroxil and ceftriaxone using 1,
2-napthaquinone-4-sulfonic acid sodium. Methods: The method was based
on the derivatization of cefadroxil and ceftriaxone with 1,
2naphthaquinone-4-sulfonic acid sodium in alkaline medium to yield
orange-colored products. Results: The reaction products of cefadroxil
and ceftriaxone at their respective λ max of 475 and 480 nm showed
linearity in the concentration range of 10 -100 and 25 -175 ”g/ml,
respectively. Relative standard deviations of 0.82 % for cefadroxil and
0.95 % for ceftriaxone were obtained. Recoveries of cefadroxil tablets
and ceftriaxone injection were in the range of 100.66 ± 0.98 and
99.38 ± 0.84 %, respectively. Conclusion: Recovery studies gave
satisfactory results indicating that none of the major
additives/excipients interfered with the assay method. Therefore, the
proposed method is simple, rapid, precise and convenient for the assay
of cefadroxil and ceftriaxone in commercial preparations
Dyes Depollution of Water Using Porous TiO2-Based Photocatalysts
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