1,556 research outputs found
Combined Palladium-Silver and Iodine-Xenon Isotope Systematics for Allegan (H5) and Dhofar 125 (Acapulcoite)
Engineering adiabaticity at an avoided crossing with optimal control
We investigate ways to optimize adiabaticity and diabaticity in the
Landau-Zener model with non-uniform sweeps. We show how diabaticity can be
engineered with a pulse consisting of a linear sweep augmented by an
oscillating term. We show that the oscillation leads to jumps in populations
whose value can be accurately modeled using a model of multiple,
photon-assisted Landau-Zener transitions, which generalizes work by Wubs et al.
[New J. Phys. 7, 218 (2005)]. We extend the study on diabaticity using methods
derived from optimal control. We also show how to preserve adiabaticity with
optimal pulses at limited time, finding a non-uniform quantum speed limit
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Long-term follow-up of 22 psoriatic patients treated with ixekizumab after failure of secukinumab
Switching of biologic agents in treatment of plaque psoriasis is a common strategy. Only a few studies are available on switching between IL17A-blockers. In a retrospective study, we identified 22 psoriasis patients who, after failing secukinumab as a first IL17A-blocker received ixekizumab with an observation period of at least 24 weeks. At last observation 10/22 patients had a good response (PASI75 or PASI<3) using ixekizumab therapy. None of five patients with primary non-response to secukinumab reached a good, durable response to ixekizumab. In conclusion, ixekizumab appears to be a therapeutic option as a second IL17A-blocker in psoriasis patients who did not show a primary non-response to secukinumab
Tuning the scattering length with an optically induced Feshbach resonance
We demonstrate optical tuning of the scattering length in a Bose-Einstein
condensate as predicted by Fedichev {\em et al.} [Phys. Rev. Lett. {\bf 77},
2913 (1996)]. In our experiment atoms in a Rb condensate are exposed to
laser light which is tuned close to the transition frequency to an excited
molecular state. By controlling the power and detuning of the laser beam we can
change the atomic scattering length over a wide range. In view of laser-driven
atomic losses we use Bragg spectroscopy as a fast method to measure the
scattering length of the atoms.Comment: submitted to PRL, 5 pages, 5 figure
Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data
Spatial patterns are ubiquitous on the subcellular, cellular and tissue level, and can be studied using imaging techniques such as light and fluorescence microscopy. Imaging data provide quantitative information about biological systems; however, mechanisms causing spatial patterning often remain elusive. In recent years, spatio-temporal mathematical modelling has helped to overcome this problem. Yet, outliers and structured noise limit modelling of whole imaging data, and models often consider spatial summary statistics. Here, we introduce an integrated data-driven modelling approach that can cope with measurement artefacts and whole imaging data. Our approach combines mechanistic models of the biological processes with robust statistical models of the measurement process. The parameters of the integrated model are calibrated using a maximum-likelihood approach. We used this integrated modelling approach to study in vivo gradients of the chemokine (C-C motif) ligand 21 (CCL21). CCL21 gradients guide dendritic cells and are important in the adaptive immune response. Using artificial data, we verified that the integrated modelling approach provides reliable parameter estimates in the presence of measurement noise and that bias and variance of these estimates are reduced compared to conventional approaches. The application to experimental data allowed the parametrization and subsequent refinement of the model using additional mechanisms. Among other results, model-based hypothesis testing predicted lymphatic vessel-dependent concentration of heparan sulfate, the binding partner of CCL21. The selected model provided an accurate description of the experimental data and was partially validated using published data. Our findings demonstrate that integrated statistical modelling of whole imaging data is computationally feasible and can provide novel biological insights
Atom-molecule dark states in a Bose-Einstein condensate
We have created a dark quantum superposition state of a Rb Bose-Einstein
condensate (BEC) and a degenerate gas of Rb ground state molecules in a
specific ro-vibrational state using two-color photoassociation. As a signature
for the decoupling of this coherent atom-molecule gas from the light field we
observe a striking suppression of photoassociation loss. In our experiment the
maximal molecule population in the dark state is limited to about 100 Rb
molecules due to laser induced decay. The experimental findings can be well
described by a simple three mode model.Comment: 4 pages, 6 figure
Molecular mode-coupling theory for supercooled liquids: Application to water
We present mode-coupling equations for the description of the slow dynamics
observed in supercooled molecular liquids close to the glass transition. The
mode-coupling theory (MCT) originally formulated to study the slow relaxation
in simple atomic liquids, and then extended to the analysis of liquids composed
by linear molecules, is here generalized to systems of arbitrarily shaped,
rigid molecules. We compare the predictions of the theory for the -vector
dependence of the molecular nonergodicity parameters, calculated by solving
numerically the molecular MCT equations in two different approximation schemes,
with ``exact'' results calculated from a molecular dynamics simulation of
supercooled water. The agreement between theory and simulation data supports
the view that MCT succeeds in describing the dynamics of supercooled molecular
liquids, even for network forming ones.Comment: 22 pages 4 figures Late
Influence of retardation effects on 2D magnetoplasmon spectrum
Within dissipationless limit the magnetic field dependence of magnetoplasmon
spectrum for unbounded 2DEG system found to intersect the cyclotron resonance
line, and, then approaches the frequency given by light dispersion relation.
Recent experiments done for macroscopic disc-shape 2DEG systems confirm theory
expectations.Comment: 2 pages,2 figure
The Star Clusters in the Irregular Galaxy NGC 4449
We examine the star clusters in the irregular galaxy NGC 4449. We use a
near-infrared spectrum and broad-band images taken with the HST to place a
limit of 8--15 Myrs on the age of the bright central ojbect in NGC 4449. Its
luminosity and size suggest that it is comparable to young super star clusters.
However, there is a peculiar nucleated-bar structure at the center of this star
cluster, and we suggest that this structure is debris from the interaction that
has produced the counter-rotating gas systems and extended gas streamers in the
galaxy.
From the images we identify 60 other candidate compact star clusters in NGC
4449. Fourteen of these could be background elliptical galaxies or old globular
star clusters. Of the star clusters, three, in addition to the central object,
are potentially super star clusters, and many others are comparable to the
populous clusters found in the LMC. The star clusters span a large range in
ages with no obvious peak in cluster formation that might be attributed to the
interaction that the galaxy has experienced.Comment: To be published in PASP, Feb. 2001; also attainable from
ftp.lowell.edu, cd pub/dah/n4449pape
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