Exotic spacetimes, superconducting strings with linear momentum, and (not quite) all that

We derive the general exact vacuum metrics associated with a stationary (non static), non rotating, cylindrically symmetric source. An analysis of the geometry described by these vacuum metrics shows that they contain a subfamily of metrics that, although admitting a consistent time orientation, display "exotic" properties, such as "trapping" of geodesics and closed causal curves through every point. The possibility that such spacetimes could be generated by a superconducting string, endowed with a neutral current and momentum, has recently been considered by Thatcher and Morgan. Our results, however, differ from those found by Thatcher and Morgan, and the discrepancy is explained. We also analyze the general possibility of constructing physical sources for the exotic metrics, and find that, under certain restrictions, they must always violate the dominant energy condition (DEC). We illustrate our results by explicitly analyzing the case of concentric shells, where we find that in all cases the external vacuum metric is non exotic if the matter in the shells satisfies the DEC.Comment: 13 pages with no figures. Accepted in PR

Temporal Progression of Aortic Valve Pathogenesis in a Mouse Model of Osteogenesis Imperfecta.

Organization of extracellular matrix (ECM) components, including collagens, proteoglycans, and elastin, is essential for maintaining the structure and function of heart valves throughout life. Mutations in ECM genes cause connective tissue disorders, including Osteogenesis Imperfecta (OI), and progressive debilitating heart valve dysfunction is common in these patients. Despite this, effective treatment options are limited to end-stage interventions. Mice with a homozygous frameshift mutation in col1a2 serve as a murine model of OI (oim/oim), and therefore, they were used in this study to examine the pathobiology of aortic valve (AoV) disease in this patient population at structural, functional, and molecular levels. Temporal echocardiography of oim/oim mice revealed AoV dysfunction by the late stages of disease in 12-month-old mice. However, structural and proteomic changes were apparent much earlier, at 3 months of age, and were associated with disturbances in ECM homeostasis primarily related to collagen and proteoglycan abnormalities and disorganization. Together, findings from this study provide insights into the underpinnings of late onset AoV dysfunction in connective tissue disease patients that can be used for the development of mechanistic-based therapies administered early to halt progression, thereby avoiding late-stage surgical intervention