PROTECTIVE ROLE OF PTEROSTILBENE ON PLASMA AND TISSUE GLYCOPROTEIN COMPONENTS IN HIGH-FAT DIET-FED AND STREPTOZOTOCIN-INDUCED TYPE 2 DIABETIC MICE

Objective: The aim of the current study is to evaluate the effect of pterostilbene (PTS), on deranged plasma and tissue glycoprotein components in high-fat-diet (HFD) and streptozotocin (STZ)-induced type 2 diabetic mice. Methods: The experimental duration was 16 weeks. The C57BL6/J mice were fed a normal diet, normal diet with PTS, HFD, and STZ injection (10th week only), and diabetic mice with PTS for the past 6 weeks. Results: A significant increase in glycoprotein components such as hexose, hexosamine, fucose, and sialic acid (SA) in plasma was observed in diabetic mice. In hepatic and renal tissues, a significant decrease in SA with an increase in other glycoprotein components was detected in diabetic mice when compared with control mice. Oral administration of PTS significantly improved the glycoprotein levels in plasma and tissues of diabetic mice to near normal level. Conclusion: In this study, we resolved that PTS improves disturbed glycoprotein metabolism in HFD and STZ-induced type 2 diabetic mice

Flexural Resistance of Steel-Coconut Shell Concrete-Steel Composite Beam with Normal and J-Hook Shear Studs

Many research on double skin sandwich having top and bottom steel plates and in between concrete core called as steel-concrete-steel (SCS) were carried out by them on this SCS type using with different materials. Yet, use of coconut shell concrete (CSC) as a core material on this SCS form construction and their results are very limited. Study investigated to use j-hook shear studs under flexure in the concept of steel-concrete-steel (SCS) in which the core concrete was CSC. To compare the results of CSC, the conventional concrete (CC) was also considered. To study the effect of quarry dust (QD) in its place of river sand (RS) was also taken. Hence four different mixes two without QD and two with QD both in CC and CSC was considered. The problem statement is to examine about partial and fully composite, moment capacity, deflection and ductility properties of CSC used SCS form of construction. Core concrete strength and the j-hook shear studs used are influences the moment carrying capacity of the SCS beams. Use of QD in its place of RS enhances the strength of concrete produced. Deflections predicted theoretically were compared with experimental results. The SCS beams showed good ductility behavior

An Empirical Analysis of Training Facilities in Micro-Small-Medium Enterprises (MSME) for Self-Help Groups (SHG)

The article presents the findings from the study on the training facilities in Micro-Small-Medium Enterprises (MSME) for Self-Help Groups (SHG) in the Union Territory of Puducherry region. The research variables were adopted in accordance to the legal provisions of SHG. Primary data of 127 random sample of MSMEs was collected through a survey method using structured questionnaire. Results show that 63% of the MSME has not undertaken any training for their suppliers, while a good proportion of the companies consisting of 15.7% have provided between 1-2 trainings. The study argues that the policy maker should identify large number of economically development-oriented skills and include them in training programmes to encourage increased development of microenterprises

Analytical review on competitive priorities for operations under manufacturing firms

Purpose: To developed and introduced a measurement scale that may be useful to assess the competitive priorities practices in the manufacturing industries. The objective is to investigate the competitive priorities domains’ implementation and its defining measurement items emphasizing manufacturing industries in the Union Territory of Puducherry. Design/methodology/approach: The essential information has been gathered from 350 manufacturing firms located in Union Territory of Puducherry; most parts of the datawere gathered from best dimension working people like Operations Managers, General Managers and Directors. For analyzing the data the researchers used SPSS and LISREL 8.72 software packages. To find out the result the researchers applied Confirmatory Factor Analysis in this research work. Findings: From the six domains analyzed the result shows that Delivery plays an important role as it occupies the first rank among the domains in competitive priority. Next to Delivery, the majority of the firms fasten more importance to Quality as it ranks second. Cost is ranked as third, while Know-how is ranked as fourth, Flexibility is ranked as fifth and Customer Focus is ranked as sixth. Practical implications: Based on the existing recommendations on scale development literature, the authors developed the measurement scale. This measurement scale is helpful for both academicians and practitioners. In this research work, the authors used the measurement scale to measure the competitive priorities domains. Originality/value: The research paper explains the manufacturing industries situated in the Union Territory of Puducherry. The researchers developed the measurement instrument of competitive priorities practices based on six domains namely quality, cost, delivery, flexibility, customer focus, and know-how. This research work gives innovative literature by recommendations and validating a measurement scale for the competitive priorities. The result reveals that the manufacturing enterprises in the Union Territory of Puducherry.Peer Reviewe

Razvoj robusnog diskretnog regulatora za silazni pretvarač s dvostrukom frekvencijom preklapanja

A discrete controller is designed for high efficiency double frequency buck converter. This double frequency buck converter is comprised of two buck cells: one works at high frequency, and another works at low frequency. It operates in a way that current in the high frequency switch is diverted through the low frequency switch. Thus, the converter can operate at very high frequency without adding any additional control circuits. Moreover, the switching loss of the converter remains small. The proposed converter exhibits improved steady -- state and transient response with low switching loss. A digital compensator further improves the dynamic performance of the closed loop system. Simulation of digitally controlled double frequency buck converter is performed with MATLAB / Simulink. Experimental results are given to demonstrate the effectiveness of the controller using LabVIEW with a Data Acquisition Card (NI - 9221).Dikretni regulator je projektiran za postizanje visoke efikasnosti silaznog pretvarača s dvostrukom frekvencijom preklapanja. Ovaj silazni pretvarač s dvostrukom frekvencijom preklapanja sastoji se od dvaju ćelija: po jedna za rad na visokim i niskim frekvencijama preklapanja. Regulator funkionira tako da se struja preklapanja na visokim frekvencijama preusmjerava kroz prekidač za preklapanje na niskim frekvencijama. Tako pretvarač može funkcionirati na vrlo visokim frekvencijama bez dodatnih upravljačkih krugova. štoviše, gubici prekidanja pretvarača ostaju mali. Prikazani pretvarač pokazuje poboljšanja kod odzivu u ustaljenom stanju te u prijelaznim pojavama uz male gubitke prilikom prekidanja. Digitalni kompenzator nadalje poboljšava dinamičke performanse sustava u zatvorenom krugu. Simulacije digitalno upravljanog silaznog pretvarača s dvostrukom frekvencijom preklapanja su provedene korištenjem MATLAB / Simulink-a. Eksperimentalni rezultati su prikazani kako bi se demonstrirala efikasnost regulatora korištenjem LabVIEW-a i kartice za prikupljanje podataka (NI - 9221)

Potential for Thermal Enhancement by Quercetin Mediated Mechanisms Targeting p53 Antagonists in Human Melanoma Cells

Introduction: Recently Temozolomide (TMZ) has become the more commonly used analog of DTIC-related oral agents. Although the response rates achieved by TMZ alone are less than satisfactory, there is great interest in identifying compounds that could be used in combination therapy. We have previously demonstrated that the bioflavonoid quercetin (Qct) promotes a p53-mediated response in melanoma and sensitizes melanoma to DTIC. Here we demonstrate that Qct also sensitizes cells to TMZ by a mechanism that involves the modulation of a truncated p53 family member, ΔNp73. Society for Thermal Medicine Annual Meeting April 23-26, Clearwater Beach, FL

Switching power control for multimode multiband power amplifier

Driven by ever-increasing consumer demand for wireless devices capable of supporting multiple air standards and applications, the implementation of multimode multiband (MMMB) power amplifier (PA) has been steadily increasing. This paper presents a design of a MMMB PA based on an industry-standard 130nm CMOS process technology, capable of operating in three power modes and in three different bands. Multiple gated transistor technique (MTGR) has been designed whereby the output power from the PA is controlled by external switching control voltage. Series combining transformer has been to adopted to achieve higher output power. The PA has 300MHz bandwidth starting from the frequency of 1.7GHz up to 2.0GHz, covering the LTE bands 1, 2 and 3, with output saturated power of 33dBm

Point Process Algorithm: A New Bayesian Approach for Planet Signal Extraction with the Terrestrial Planet Finder

The capability of the Terrestrial Planet Finder Interferometer (TPF-I) for planetary signal extraction, including both detection and spectral characterization, can be optimized by taking proper account of instrumental characteristics and astrophysical prior information. We have developed the Point Process Algorithm (PPA), a Bayesian technique for extracting planetary signals using the sine-chopped outputs of a dual nulling interferometer. It is so-called because it represents the system being observed as a set of points in a suitably-defined state space, thus providing a natural way of incorporating our prior knowledge of the compact nature of the targets of interest. It can also incorporate the spatial covariance of the exozodi as prior information which could help mitigate against false detections. Data at multiple wavelengths are used simultaneously, taking into account possible spectral variations of the planetary signals. Input parameters include the RMS measurement noise and the a priori probability of the presence of a planet. The output can be represented as an image of the intensity distribution on the sky, optimized for the detection of point sources. Previous approaches by others to the problem of planet detection for TPF-I have relied on the potentially non-robust identification of peaks in a "dirty" image, usually a correlation map. Tests with synthetic data suggest that the PPA provides greater sensitivity to faint sources than does the standard approach (correlation map + CLEAN), and will be a useful tool for optimizing the design of TPF-I.Comment: 17 pages, 6 figures. AJ in press (scheduled for Nov 2006

RF CMOS switch design methodologies for multiband transceiver applications

Multimode multiband connectivity has become a de-facto requirement for smartphones with 3G WCDMA/4G LTE applications. In transceivers, multiband operation is achieved by selecting an output from two or more signal path targeting for a specific frequency range in parallel or by using switched capacitor/inductor. In this paper, design methodology of 280nm CMOS switch is presented. Design optimization of RF CMOS switch is presented which is deciding proper selection of CMOS transistor parameters and switch size as per external circuit parameters. The CMOS switch of a 5-transistor stack with W/L=1200µm/280nm provides insertion loss 14dB. The switches designed when implemented in a multiband power amplifier (PA) exhibits 36dB gain at 1900MHz high-band and 34.5dB gain at 900MHz low-band with 27.5dBm peak power at both bands. The switch design methodologies presented in this paper should be of use in designing various blocks in emerging multiband transceiver applications