45 research outputs found
Large angle magnetization dynamics measured by time-resolved ferromagnetic resonance
A time-resolved ferromagnetic resonance technique was used to investigate the
magnetization dynamics of a 10 nm thin Permalloy film. The experiment consisted
of a sequence of magnetic field pulses at a repetition rate equal to the
magnetic systems resonance frequency. We compared data obtained by this
technique with conventional pulsed inductive microwave magnetometry. The
results for damping and frequency response obtained by these two different
methods coincide in the limit of a small angle excitation. However, when
applying large amplitude field pulses, the magnetization had a non-linear
response. We speculate that one possible cause of the nonlinearity is related
to self-amplification of incoherence, known as the Suhl instabilities.Comment: 23 pages, 8 figures, submitted to PR
Spatially resolved ultrafast precessional magnetization reversal
Spatially resolved measurements of quasi-ballistic precessional magnetic
switching in a microstructure are presented. Crossing current wires allow
detailed study of the precessional switching induced by coincident longitudinal
and transverse magnetic field pulses. Though the response is initially
spatially uniform, dephasing occurs leading to nonuniformity and transient
demagnetization. This nonuniformity comes in spite of a novel method for
suppression of end domains in remanence. The results have implications for the
reliability of ballistic precessional switching in magnetic devices.Comment: 17 pages (including 4 figures), submitted to Phys. Rev. Let
Switching of magnetization by non-linear resonance studied in single nanoparticles
Magnetization reversal in magnetic particles is one of the fundamental issues
in magnetic data storage. Technological improvements require the understanding
of dynamical magnetization reversal processes at nanosecond time scales. New
strategies are needed to overcome current limitations. For example, the problem
of thermal stability of the magnetization state (superparamagnetic limit) can
be pushed down to smaller particle sizes by increasing the magnetic anisotropy.
High fields are then needed to reverse the magnetization that are difficult to
achieve in current devices. Here we propose a new method to overcome this
limitation. A constant applied field, well below the switching field, combined
with a radio-frequency (RF) field pulse can reverse the magnetization of a
nanoparticle. The efficiency of this method is demonstrated on a 20 nm cobalt
particle by using the micro-SQUID technique. Other applications of this method
might be nucleation or depinning of domain walls.Comment: 11 pages, 5 figure
Tunable energy transfer between dipolar-coupled magnetic disks by stimulated vortex gyration
A wide variety of coupled harmonic oscillators exist in nature1. Coupling
between different oscillators allows for the possibility of mutual energy
transfer between them2-4 and the information-signal propagation5,6. Low-energy
input signals and their transport with low-energy dissipation are the key
technical factors in the design of information processing devices7. Here,
utilizing the concept of coupled oscillators, we experimentally demonstrated a
robust new mechanism for energy transfer between spatially separated
dipolar-coupled magnetic disks - stimulated vortex gyration. Direct
experimental evidence was obtained by time-resolved soft X-ray microscopy. The
rate of energy transfer from one disk to the other was deduced from the two
normal modes' frequency splitting caused by dipolar interaction. This mechanism
provides the advantages of tunable energy transfer rate, low-power input
signal, and low-energy dissipation for magnetic elements with negligible
damping. Coupled vortex-state disks are promising candidates for
information-signal processing devices that operate above room temperature
Imaging the dephasing of spin wave modes in a square thin film magnetic element
Copyright © 2004 The American Physical SocietyWe have used time-resolved scanning Kerr effect microscopy to study dephasing of spin wave modes in a square Ni81Fe19 element of 10 μm width and 150 nm thickness. When a static magnetic field H was applied parallel to an edge of the square, demagnetized regions appeared at the edges orthogonal to the field. When H was applied along a diagonal, a demagnetized region appeared along the opposite diagonal. Time-resolved images of the out-of-plane magnetization component showed stripes that lie perpendicular to H and indicate the presence of spin wave modes with wave vector parallel to the static magnetization. The transient Kerr rotation was measured at different positions along an axis parallel to H, and the power spectra revealed a number of different modes. Micromagnetic simulations reproduce both the observed images and the mode frequencies. This study allows us to understand an anisotropic damping observed at the center of the square element in terms of dephasing of the resonant mode spectrum
Circulating microparticles: square the circle
Background: The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance. Results: MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50 and 1000 nm. MPs are capable of transferring peptides, proteins, lipid components, microRNA, mRNA, and DNA from one cell to another without direct cell-to-cell contact. Growing evidence suggests that MPs present in peripheral blood and body fluids contribute to the development and progression of cancer, and are of pathophysiological relevance for autoimmune, inflammatory, infectious, cardiovascular, hematological, and other diseases. MPs have large diagnostic potential as biomarkers; however, due to current technological limitations in purification of MPs and an absence of standardized methods of MP detection, challenges remain in validating the potential of MPs as a non-invasive and early diagnostic platform. Conclusions: Improvements in the effective deciphering of MP molecular signatures will be critical not only for diagnostics, but also for the evaluation of treatment regimens and predicting disease outcomes
Pharmacoperones for misfolded gonadotropin receptors
The gonadotropin receptors (luteinising hormone receptor; LHR and follicle-stimulating hormone receptor; FSHR) are G protein-coupled receptors (GPCRs) that play an important role in the endocrine control of reproduction. Thus genetic mutations that cause impaired function of these receptors have been implicated in a number of reproductive disorders. Disease-causing genetic mutations in GPCRs frequently result in intracellular retention and degradation of the nascent protein through misfolding and subsequent recognition by cellular quality control machinery. The discovery and development of novel compounds termed pharmacological chaperones (pharmacoperones) that can stabilise misfolded receptors and restore trafficking and plasma membrane expression are therefore of great interest clinically, and promising in vitro data describing the pharmacoperone rescue of a number of intracellularly retained mutant GPCRs has provided a platform for taking these compounds into in vivo trials. Thienopyrimidine small molecule allosteric gonadotropin receptor agonists (Org 42599 and Org 41841) have been demonstrated to have pharmacoperone activity. These compounds can rescue cell surface expression and in many cases, hormone responsiveness, of a range of retained mutant gonadotropin receptors. Should gonadotropin receptor selectivity of these compounds be improved, they could offer therapeutic benefit to subsets of patients suffering from reproductive disorders attributed to defective gonadotropin receptor trafficking.https://www.springer.com/series/1642018-12-01hj2018Immunolog
The effect of gonadectomy on the clinical course of chronic experimental allergic encephalomyelitis
Experimental allergic encephalomyelitis (EAE) is an animal model for the human neurological disease multiple sclerosis (MS). Upon immunization with guinea pig spinal cord under a low dose of Cyclosporin A, male Lewis rats develop a severe chronic (relapsing) course of EAE (CR-EAE). By contrast, female Lewis rats develop a more mitigated course of EAE: only half of the female rats develop relapses. To Further analyze factors determining this sexual dimorphism in the course of EAE, in the present study male and female Lewis rats were gonadectomized before induction of CR-EAE. Now both male and female rats all developed a severe chronic course of EAE, showing extensive pathological changes in the CNS. In the female sham-gonadectomy (control) group only one third of the rats developed relapses. These female rats only showed mild pathological changes in the CNS. In the male sham-gonadectomy (control) group all rats developed relapses of EAE and showed extensive pathological changes in the CNS. From these data we conclude that the presence of the ovaries (partially) protects female rats against relapses of EAE and CNS injury. Presence or absence of the testes apparently makes no difference on the course of EAE. We propose that sex hormones produced in the ovaries protect female rats against relapses of EAE and underlying CNS injury