Hydrogenation processes at the surface of ruthenium nanoparticles: A NMR study

1022-5528The reactivity of ruthenium nanoparticles stabilized by 4-(3-phenylpropyl)pyridine in hydrogen transfer and hydrogenation processes was monitored by NMR spectroscopy. Unsaturated substrates such as styrene, 4-vinylpyridine and 4-phenyl-but-3-en-2-one were used as model molecules to investigate the surface properties of nanoparticles by a combination of NMR studies. Interestingly, the hydrides present at the metallic surface after nanoparticles synthesis are selectively transferred to vinylic groups without reducing the aromatic rings, under dihydrogen-free atmosphere. DOSY and NOE NMR experiments permitted to propose a way of interaction of the organic compounds at the metallic surface. In particular, the coordination of the substrate could be evidenced for 4-vinylpyridine and 4-ethylpyridine but not for styrene derivatives. Curved double arrows represent magnetization exchanges. Straight arrows represent adsorption/desorption phenomena

Membranous glomerulonephritis as a novel paraneoplastic syndrome in a young man with chronic myeloid leukemia

International audienc

Renal adverse effects of immune checkpoints inhibitors in clinical practice: ImmuNoTox study

International audienceBackground/objectives: Acute Kidney Injury (AKI), induced by Checkpoint Inhibitors therapies (CPI-induced AKI), is an uncommon but severe Immune-Related Adverse Event (IRAE). The aim was to describe the epidemiology, risks factors, clinical, and laboratory characteristics of these renal adverse events (AEs) in a real-life cohort treatment.Design/participants: Consecutive patients undergoing a checkpoint inhibitor (CPI) therapy at the Hopital Lyon Sud from January 2015 to July 2017 were included. A systematic retrospective analysis of medical files was performed, monthly serum creatinine levels, associated treatments, and occurrence of other IRAEs data were collected. AKI episodes explained by classic AKI aetiologies (prerenal, obstructive, septic) were excluded from the analysis.Results: CPI-induced AKI incidence was 3.7% (13/ 352) and appeared to be time- dependent (7.7% (11/143) for patients with >3 months of CPI exposure), ranging from 1 to 16 months. All cases with available histology were acute tubulointerstitial nephritis (ATIN), with poor urinary sediment. The severity of AKI was mild (stage 1 in 50% of cases), with no need for renal-replacement therapy. Although CPI-induced AKI patients had more frequently other IRAEs (77% versus 39%), this was not associated with a greater risk of AKI. Pre-existing chronic kidney disease (defined as an estimated glomerular filtration rate (eGFR) <60 ml/ min) was not associated with a greater risk of CPI-induced AKI. Treatments of CPIinduced AKI were heterogeneous, with discontinuation of CPIs, and inconstant systemic corticosteroid therapy.Conclusion: The monitoring of renal function and early identification of AKI during CPIs treatment is essential. The optimal management of CPI-induced AKI remains unclear and requires a close collaboration between the oncology and nephrology departments

Integrating catalyst and co-catalyst design in olefin polymerization catalysis: Transferable dianionic ligands for the activation of late transition metal polymerization catalysts

10 páginas, figurasTreatment of nickel and palladium alpha-diimine catecholate complexes with alkylaluminum catecholates leads to active ethylene polymerization catalysts. Comparison of the catalytic activities achieved with combinations of alpha-diimine catecholate or halide complexes as catalyst precursors with different activators (MMAO or alkylaluminum catecholates) reveals that the presence of the catecholate ligand in both catalyst components is beneficial for achieving high activity levels at very low M/Al ratios.Financial support from the DGI (Project CTQ2006–05527/BQU), Junta de Andalucia and Repsol-YPF is gratefully acknowledged. M. D. and E. T. gratefully thank research contracts from the European Union (Research and Training Network RTN1–1999–00164 “Polycat”).Peer reviewe