Modelling of River Flow and Sediment Load Based on the Hydrological Behavior Model in Yahagi River Basin, Japan

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Molecular Mechanisms of Receptor-Mediated Endocytosis in the Renal Proximal Tubular Epithelium

Receptor-mediated endocytosis is a pivotal function of renal proximal tubule epithelial cells (PTECs) to reabsorb and metabolize substantial amounts of proteins and other substances in glomerular filtrates. The function accounts for the conservation of nutrients, including carrier-bound vitamins and trace elements, filtered by glomeruli. Impairment of the process results in a loss of such substances and development of proteinuria, an important clinical sign of kidney disease and a risk marker for cardiovascular disease. Megalin is a multiligand endocytic receptor expressed at clathrin-coated pits of PTEC, playing a central role in the process. Megalin cooperates with various membrane molecules and interacts with many intracellular adaptor proteins for endocytic trafficking. Megalin is also involved in signaling pathways in the cells. Megalin-mediated endocytic overload leads to damage of PTEC. Further studies are needed to elucidate the mechanism of megalin-mediated endocytosis and develop strategies for preventing the damage of PTEC

Shear Resistance Mechanisms on Steel Sheet Shear Walls with Burring Holes and Cross-Rails

Steel sheet shear walls with burring holes are employed in low and mid-rise buildings in seismically active regions. A configuration with burrs on the inside enables the thinner wall and omitting the machining of equipment holes. The effects of cross-rails which are generally designed to strengthen the bearing capacities of the studs, on 2.73~4.53m height shear walls were clarified by finite element analysis and experiments. Post-buckling behavior depends on tension fields restrained by the cross-rails. The formulas of the allowable strengths and the indexes of ultimate strengths were developed using the mechanisms

Shear Resistance Mechanisms on Steel Sheet Shear Walls with Burring Holes and Cross-Rails

Steel sheet shear walls with burring holes are employed in low and mid-rise buildings in seismically active regions. A configuration with burrs on the inside enables the thinner wall and omitting the machining of equipment holes. The effects of cross-rails which are generally designed to strengthen the bearing capacities of the studs, on 2.73~4.53m height shear walls were clarified by finite element analysis and experiments. Post-buckling behavior depends on tension fields restrained by the cross-rails. The formulas of the allowable strengths and the indexes of ultimate strengths were developed using the mechanisms