Hypotension due to Chemotherapy in a Patient with Small Cell Lung Cancer and Lambert-Eaton Myasthenic Syndrome Undergoing Hemodialysis: A First Case Report

We present the first case of small cell lung cancer with Lambert-Eaton myasthenic syndrome during hemodialysis (HD). A 72-year-old male patient receiving HD experienced progressive muscle weakness. He was diagnosed with small cell lung cancer with Lambert-Eaton myasthenic syndrome due to an increased serum level of anti-voltage-gated calcium channel antibody and aspiration cytology on endobronchial ultrasonography for the swelling of a subcarinal lymph node. He received chemotherapy consisting of carboplatin (300 mg/m2) and etoposide (50 mg/m2), to which he had a partial response. However, the second therapy course could not be administered because of the unexpected development of severe hematological adverse events, which also prevented him from undergoing further HD. This case indicates that caution should be taken when using chemotherapy for such patients because of hypotension due to chemotherapy, with which it is impossible to undergo HD

Growing Local arm inferred by the breathing motion

Theoretical models of spiral arms suggest that the spiral arms provoke a vertical bulk motion in disc stars. By analysing the breathing motion, a coherent asymmetric vertical motion around the mid-plane of the Milky Way disc, with Gaia DR3, we found that a compressing breathing motion presents along the Local arm. On the other hand, with an N-body simulation of an isolated Milky Way-like disc galaxy, we found that the transient and dynamic spiral arms induce compressing breathing motions when the arms are in the growth phase, while the expanding breathing motion appears in the disruption phase. The observed clear alignment of the compressing breathing motion with the Local arm is similar to what is seen in the growth phase of the simulated spiral arms. Hence, we suggest that the Local arm’s compressing breathing motion can be explained by the Local arm being in the growth phase of a transient and dynamic spiral arm. We also identified the tentative signatures of the expanding breathing motion associated with the Perseus arm and also the Outer arm coinciding with the compressing breathing motion. This may infer that the Perseus and Outer arms are in the disruption and growth phases, respectively

Impact of bar resonances in the velocity-space distribution of the solar neighbourhood stars in a self-consistent NN-body Galactic disc simulation

The velocity-space distribution of the solar neighbourhood stars shows complex substructures. Most of the previous studies use static potentials to investigate their origins. Instead we use a self-consistent $N$-body model of the Milky Way, whose potential is asymmetric and evolves with time. In this paper, we quantitatively evaluate the similarities of the velocity-space distributions in the $N$-body model and that of the solar neighbourhood, using Kullback-Leibler divergence (KLD). The KLD analysis shows the time evolution and spatial variation of the velocity-space distribution. The KLD fluctuates with time, which indicates the velocity-space distribution at a fixed position is not always similar to that of the solar neighbourhood. Some positions show velocity-space distributions with small KLDs (high similarities) more frequently than others. One of them locates at $(R,\phi)=(8.2\;\mathrm{kpc}, 30^{\circ})$, where $R$ and $\phi$ are the distance from the galactic centre and the angle with respect to the bar's major axis, respectively. The detection frequency is higher in the inter-arm regions than in the arm regions. In the velocity maps with small KLDs, we identify the velocity-space substructures, which consist of particles trapped in bar resonances. The bar resonances have significant impact on the stellar velocity-space distribution even though the galactic potential is not static.Comment: 9 pages, 11 figures. Accepted by MNRA

Trimodal structure of Hercules stream explained by originating from bar resonances

Gaia Data Release 2 revealed detailed structures of nearby stars in phase space. These include the Hercules stream, whose origin is still debated. Most of the previous numerical studies conjectured that the observed structures originate from orbits in resonance with the bar, based on static potential models for the Milky Way. We, in contrast, approach the problem via a self-consistent, dynamic, and morphologically well-resolved model, namely a full $N$-body simulation of the Milky Way. Our simulation comprises about 5.1 billion particles in the galactic stellar bulge, bar, disk, and dark-matter halo and is evolved to 10 Gyr. Our model's disk component is composed of 200 million particles, and its simulation snapshots are stored every 10 Myr, enabling us to resolve and classify resonant orbits of representative samples of stars. After choosing the Sun's position in the simulation, we compare the distribution of stars in its neighborhood with Gaia's astrometric data, thereby establishing the role of identified resonantly trapped stars in the formation of Hercules-like structures. From our orbital spectral-analysis we identify multiple, especially higher order resonances. Our results suggest that the Hercules stream is dominated by the 4:1 and 5:1 outer Lindblad and corotation resonances. In total, this yields a trimodal structure of the Hercules stream. From the relation between resonances and ridges in phase space, our model favored a slow pattern speed of the Milky-Way bar (40--45 $\mathrm{km \; s^{-1} \; kpc^{-1}}$).Comment: 11 pages, 9 figures, MNRAS accepte

Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: Focusing on neuroprotective effects of stromal cell-derived factor-1α

<p>Abstract</p> <p>Background</p> <p>Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from bone marrow with secretory functions of various neurotrophic factors. Stromal cell-derived factor-1α (SDF-1α) is also reported as one of chemokines released from MSCs. In this research, the therapeutic effects of MSCs through SDF-1α were explored. 6-hydroxydopamine (6-OHDA, 20 μg) was injected into the right striatum of female SD rats with subsequent administration of GFP-labeled MSCs, fibroblasts, (i.v., 1 × 10⁷cells, respectively) or PBS at 2 hours after 6-OHDA injection. All rats were evaluated behaviorally with cylinder test and amphetamine-induced rotation test for 1 month with consequent euthanasia for immunohistochemical evaluations. Additionally, to explore the underlying mechanisms, neuroprotective effects of SDF-1α were explored using 6-OHDA-exposed PC12 cells by using dopamine (DA) assay and TdT-mediated dUTP-biotin nick-end labeling (TUNEL) staining.</p> <p>Results</p> <p>Rats receiving MSC transplantation significantly ameliorated behaviorally both in cylinder test and amphetamine-induced rotation test compared with the control groups. Correspondingly, rats with MSCs displayed significant preservation in the density of tyrosine hydroxylase (TH)-positive fibers in the striatum and the number of TH-positive neurons in the substantia nigra pars compacta (SNc) compared to that of control rats. In the <it>in vitro </it>study, SDF-1α treatment increased DA release and suppressed cell death induced by 6-OHDA administration compared with the control groups.</p> <p>Conclusions</p> <p>Consequently, MSC transplantation might exert neuroprotection on 6-OHDA-exposed dopaminergic neurons at least partly through anti-apoptotic effects of SDF-1α. The results demonstrate the potentials of intravenous MSC administration for clinical applications, although further explorations are required.</p

Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons

<p>Abstract</p> <p>Background</p> <p>Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the neuroprotective effects of edaravone (MCI-186, 3-methyl-1-phenyl-2-pyrazolin-5-one), which has already been used for the treatment of cerebral ischemia in Japan, on TH-positive dopaminergic neurons using PD model both <it>in vitro </it>and <it>in vivo</it>. 6-hydroxydopamine (6-OHDA), a neurotoxin for dopaminergic neurons, was added to cultured dopaminergic neurons derived from murine embryonal ventral mesencephalon with subsequet administration of edaravone or saline. The number of surviving TH-positive neurons and the degree of cell damage induced by free radicals were analyzed. In parallel, edaravone or saline was intravenously administered for PD model of rats receiving intrastriatal 6-OHDA lesion with subsequent behavioral and histological analyses.</p> <p>Results</p> <p><it>In vitro </it>study showed that edaravone significantly ameliorated the survival of TH-positive neurons in a dose-responsive manner. The number of apoptotic cells and HEt-positive cells significantly decreased, thus indicating that the neuroprotective effects of edaravone might be mediated by anti-apoptotic effects through the suppression of free radicals by edaravone. <it>In vivo </it>study demonstrated that edaravone-administration at 30 minutes after 6-OHDA lesion reduced the number of amphetamine-induced rotations significantly than edaravone-administration at 24 hours. Tyrosine hydroxylase (TH) staining of the striatum and substantia nigra pars compacta revealed that edaravone might exert neuroprotective effects on nigrostriatal dopaminergic systems. The neuroprotective effects were prominent when edaravone was administered early and in high concentration. TUNEL, HEt and Iba-1 staining <it>in vivo </it>might demonstrate the involvement of anti-apoptotic, anti-oxidative and anti-inflammatory effects of edaravone-administration.</p> <p>Conclusion</p> <p>Edaravone exerts neuroprotective effects on PD model both <it>in vitro and in vivo</it>. The underlying mechanisms might be involved in the anti-apoptotic effects, anti-oxidative effects, and/or anti-inflammatory effects of edaravone. Edaravone might be a hopeful therapeutic option for PD, although the high therapeutic dosage remains to be solved for the clinical application.</p

Stress control and human nutrition

Stress is a pervasive factor in everyday life that critically affects development and functioning. Severe and prolonged stress exposure impairs homeostatic mechanisms, particularly associated with the onset of depressive illness. Brain food is aimed at preventing as well as treating a growing number of stress-related mental disorders. Some topics on the association of stress and nutrition is reviewed. (1) An increased activity of serotonergic neurons in the brain is an established consequence of stress. An increase in brain tryptophan levels on the order of that produced by eating a carbohydrate-rich/protein-poor meal causes parallel increases in the amounts of serotonin released into synapses. (2) Eating is thought to be suppressed during stress, due to anorectic effects of corticotrophin releasing hormone, and increased during recovery from stress, due to appetite stimulating effects of residual cortisol. (3) A strong inverse association between coffee intake and risk of suicide. (4) Night eating syndrome has been found to occur during periods of stress and is associated with poor results at attempts to lose weight and disturbances in the hypothalamic-pituitaryadrenal axis. (5) Dietary antioxidants present in fruits and vegetables may improve cognitive function. Therefore, it is concluded that the establishment of functional foods that correctly regulate stress response must be firmly based upon scientific knowledge and legal regulation