Radioprotective Effect of Vitamin C as an Antioxidant

Vitamin C is known as a potent antioxidant. We studied vitamin C as a radioprotective agent, focusing on its antioxidative effect. When the body is exposed to radiation, free radicals and reactive oxygen species (ROS) are produced and oxidize cell components, resulting in cell damage. Vitamin C has the potential to scavenge these radical products, thereby protecting against radiation-induced cell damage. We investigated the effects of vitamin C on radiation-induced gastrointestinal (GI) syndrome in mice. The mice received whole-body irradiation followed by bone marrow transplantation 24 h after exposure. Despite avoiding bone marrow failure, the mice eventually died of GI syndrome. Pretreatment with per os administration of high-dose vitamin C effectively mitigated radiation-induced GI syndrome and improved mouse survivals, while per os post-treatment with vitamin C was ineffective, presumably due to impaired absorption from the radiation-damaged intestine. We also investigated the effect of post-exposure treatment with intraperitoneal administration of vitamin C on radiation-induced bone marrow dysfunction in mice. Intraperitoneal administration with high-dose vitamin C, even at 24 h after whole-body irradiation, was still effective in avoiding bone marrow dysfunction, thereby increasing mouse survival after radiation. In conclusion, administration of high-dose vitamin C effectively reduced the radiation lethality in mice

On Ultraviolet Absorption of a Component from Leaves of the Photo periodically Induced Plant

ArticleJournal of the Faculty of Liberal Arts and Science, Shinshu University. Part 2, Natural science 10: 7-13(1961)departmental bulletin pape

Net Production in Several Mature Plants Grown at Different Altitudes

The net productions of Polygonum reynoutria L. ssp. asiatica, Solidago virgaaurea L. ssp. asiatica, and Prunella vulgaris L. ssp. asiatica were measured by the leaf-half method modified monthly in several native habitats of different altitude. With P. reynoutria, the net productivity was decreased from late July to late September, and also was decreased in higher habitats. The productivities of S. virga-aurea and P. vulgaris, however, were increased from late July to late August, and from about 600m to about 1500m elevation in the same season, and then decreased in both cases. The temperature that showed the maximum productivity was lower in S. virga-aurea than in P. vulgaris. It was suggested that the plants distribution of these 3 species may be related to the difference in their productivities.Article信州大学理学部紀要 10(1): 35-39(1975)departmental bulletin pape

Advanced Applications of Wireless Sensor Network Using Sensor Cloud Infrastructure

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Photosynthesis in Polygonum reynoutria L. ssp. asiatica Grown at Different Altitudes

A relation between environmental conditions and photosynthetic ability was investigated with Polygonum reynoutria L. ssp. asiatica growing in various conditions. The optimum and the maximum temperatures for photosynthesis in the plants under field conditions varied seasonally with the variation of air-temperature. Both temperatures were located on much lower level with the plants grown at high elevation. In their seedlings cultured under an artificial controlled condition, the optimum temperature differed to every seed-source which was different in environmental temperature. The optimum temperature had a wide range in the plants grown natively at low elevation, and had a narrow range in those grown natively at high elevation. The width of the range was narrowed by transplantation into high elevation from low one, and was similar to that of the range in the native plants in the habitat into which the plants were transplanted. The width, however, was never changed by transplantation into low elevation from high one. The optimum and the maximum temperatures for photosynthesis may be genotypically decided, although both temperatures showed a variance with the seasonal variation of air-temperature. Such plasticity on both temperatures for photosynthesis seems to be larger in the plants grown natively at low elevation than ones grown natively at high elevation.Article信州大学理学部紀要 10(1): 27-34(1975)departmental bulletin pape

A Bankruptcy Problem Approach to Load-shedding in Multiagent-based Microgrid Operation

A microgrid is composed of distributed power generation systems (DGs), distributed energy storage devices (DSs), and loads. To maintain a specific frequency in the islanded mode as an important requirement, the control of DGs’ output and charge action of DSs are used in supply surplus conditions and load-shedding and discharge action of DSs are used in supply shortage conditions. Recently, multiagent systems for autonomous microgrid operation have been studied. Especially, load-shedding, which is intentional reduction of electricity use, is a critical problem in islanded microgrid operation based on the multiagent system. Therefore, effective schemes for load-shedding are required. Meanwhile, the bankruptcy problem deals with dividing short resources among multiple agents. In order to solve the bankruptcy problem, division rules, such as the constrained equal awards rule (CEA), the constrained equal losses rule (CEL), and the random arrival rule (RA), have been used. In this paper, we approach load-shedding as a bankruptcy problem. We compare load-shedding results by above-mentioned rules in islanded microgrid operation based on wireless sensor network (WSN) as the communication link for an agent’s interactions

A New Algorithm for Numerical Calculation of Link Invariants

We propose a new method for numerical calculation of link plynomials for knots given in 3 dimensions. We calculate derivatives of the Jones polynomial in a computational time proportional to $N^{\alpha}$ with respect to the system size $N$ . This method gives a new tool for determining topology of knotted closed loops in three dimensions using computers.Comment: 20 pages, September 199

Ectopic expression of Klotho in fibroblast growth factor 23 (FGF23)-producing tumors that cause tumor-induced rickets/osteomalacia (TIO)

Tumor-induced rickets/osteomalacia (TIO) is a rare paraneoplastic syndrome caused by tumors that ectopically express fibroblast growth factor 23 (FGF23). FGF23 is a bone-derived hormone that regulates serum phosphate concentrations. Patients with TIO develop hypophosphatemic rickets/osteomalacia due to FGF23 excess and suffer from symptoms such as leg deformities, bone pain, skeletal muscle myopathy, and multiple fractures/ pseudofractures. Usually, successful surgical removal of the causative tumors normalizes serum FGF23 and phosphate concentrations in patients with TIO. Most FGF23-producing tumors associated with TIO are histologically called phosphaturic mesenchymal tumor, mixed connective tissue variant (PMTMCT). The precise mechanism by which these tumors ectopically overproduce FGF23 outside of bone is yet to be clarified. Therefore, we performed an RNA sequencing analysis of a PMTMCT that was found in the left parotid gland of a patient with TIO. Among the upregulated genes, we focused on Klotho, the protein product of which is a single pass transmembrane protein that works along with an FGF receptor 1c as a receptor complex for FGF23. Subsequent histological analysis confirmed the ectopic expression of Klotho in other PMTMCTs. From these results, we assume that the ectopic expression of Klotho in PTMMCTs enables a positive feedback loop in FGF23 production via the activation of FGF receptor 1c and exacerbates disease manifestations in TIO

Cervicomediastinal Lipoma

A 67-year-old female was hospitalized with complaints of cough and shortness of breath. A chest roentgenogram showed a right upper mediatinal mass. Computed tomography demonstrated a well circumscribed large mass, with a fat density, extending from the azygos arch to the thyroid cartilage. The mass displaced the superior vena cava anteriorly and trachea laterally to the left. It was hourglass shaped, 250g in weight and could be easily removed completely along with the thoracic portion from the cervix. The histologic findings were consistent with lipoma. Its CT diagnosis was discussed