68 research outputs found
The Discovery of a Very Narrow-Line Star Forming Obat a Redshift of 5.66ject
We report on the discovery of a very narrow-line star forming object beyond
redshift of 5. Using the prime-focus camera, Suprime-Cam, on the 8.2 m Subaru
telescope together with a narrow-passband filter centered at
= 8150 \AA with passband of = 120 \AA, we have obtained a very
deep image of the field surrounding the quasar SDSSp J104433.04012502.2 at a
redshift of 5.74. Comparing this image with optical broad-band images, we have
found an object with a very strong emission line. Our follow-up optical
spectroscopy has revealed that this source is at a redshift of
, forming stars at a rate
yr. Remarkably, the velocity dispersion of Ly-emitting gas is
only 22 km s. Since a blue half of the Ly emission could be
absorbed by neutral hydrogen gas, perhaps in the system, a modest estimate of
the velocity dispersion may be 44 km s. Together with a linear
size of 7.7 kpc, we estimate a lower limit of the dynamical mass
of this object to be . It is thus suggested that
LAE J10440123 is a star-forming dwarf galaxy (i.e., a subgalactic object or
a building block) beyond redshift 5 although we cannot exclude a possibility
that most Ly emission is absorbed by the red damping wing of neutral
intergalactic matter.Comment: 6 pages, 2 figures. ApJ Letters, in pres
A Focal Mass-Forming Autoimmune Pancreatitis Mimicking Pancreatic Cancer with Obstruction of the Main Pancreatic Duct
Pancreatic Volumetric Assessment as a Predictor of New-Onset Diabetes Following Distal Pancreatectomy
M1230 Thymidylate Synthase Expression May Be Related to the Antitumor Effect of S-1 in Patients with Biliary Tract Cancer
S1789 Decreased Expression of Intestinal Chemokine TECK/CCL25 in Experimental Obstructive Jaundice and Its Reversal By Internal Biliary Drainage
Pharmacokinetic study of adjuvant gemcitabine therapy for biliary tract cancer following major hepatectomy (KHBO1101)
Background: Biliary tract cancer (BTC) patients who have undergone surgical resection with major hepatectomy cannot tolerate the standard gemcitabine regimen (1, 000 mg/m2 on days 1, 8, and 15 every 4 weeks) due to severe toxicities such as myelosuppression. Our dose-finding study of adjuvant gemcitabine therapy for biliary tract cancer following major hepatectomy determined that the recommended dose is 1, 000 mg/m2 on days 1 and 15 every 4 weeks. Here, we evaluate the pharmacokinetics and pharmacodynamics of gemcitabine in these subjects. Methods: We evaluated BTC patients scheduled to undergo surgical resection with major hepatectomy followed by gemcitabine therapy. A pharmacokinetic evaluation of gemcitabine and its main metabolite, 2′, 2′-difluorodeoxyuridine (dFdU), was conducted at the initial administration of gemcitabine, which was given by intravenous infusion over 30 min at a dose of 800-1, 000 mg/m2. Physical examination and adverse events were monitored for 12 weeks. Results: Thirteen patients were enrolled from August 2011 to January 2013, with 12 ultimately completing the pharmacokinetic study. Eight patients had hilar cholangiocarcinoma, three had intrahepatic cholangiocarcinoma, and one had superficial spreading type cholangiocarcinoma. The median interval from surgery to first administration of gemcitabine was 65.5 days (range, 43-83 days). We observed the following toxicities: neutropenia (n = 11, 91.7%), leukopenia (n = 10, 83.3%), thrombocytopenia (n = 6, 50.0%), and infection (n = 5, 41.7%). Grade 3 or 4 neutropenia was observed in 25% (n = 3) of patients. There were differences in clearance of gemcitabine and dFdU between our subjects and the subjects who had not undergone hepatectomy. Conclusion: Major hepatectomy did not affect the pharmacokinetics of gemcitabine or dFdU. Trial Registration: UMIN-CTR in (JPRN) UMIN000005109
Double Cancer of Gall Bladder and Bile Duct not Associated with Anomalous Junction of the Pancreaticobiliary Duct System
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