Uniform estimates of nonlinear spectral gaps

By generalizing the path method, we show that nonlinear spectral gaps of a finite connected graph are uniformly bounded from below by a positive constant which is independent of the target metric space. We apply our result to an $r$-ball $T_{d,r}$ in the $d$-regular tree, and observe that the asymptotic behavior of nonlinear spectral gaps of $T_{d,r}$ as $r\to\infty$ does not depend on the target metric space, which is in contrast to the case of a sequence of expanders. We also apply our result to the $n$-dimensional Hamming cube $H_n$ and obtain an estimate of its nonlinear spectral gap with respect to an arbitrary metric space, which is asymptotically sharp as $n\to\infty$.Comment: to appear in Graphs and Combinatoric

On the Design Rationale of SIMON Block Cipher: Integral Attacks and Impossible Differential Attacks against SIMON Variants

SIMON is a lightweight block cipher designed by NSA in 2013. NSA presented the specification and the implementation efficiency, but they did not provide detailed security analysis nor the design rationale. The original SIMON has rotation constants of $(1,8,2)$, and Kölbl {\it et al}.~regarded the constants as a parameter $(a,b,c)$, and analyzed the security of SIMON block cipher variants against differential and linear attacks for all the choices of $(a,b,c)$. This paper complements the result of Kölbl {\it et al}.~by considering integral and impossible differential attacks. First, we search the number of rounds of integral distinguishers by using a supercomputer. Our search algorithm follows the previous approach by Wang {\it et al}., however, we introduce a new choice of the set of plaintexts satisfying the integral property. We show that the new choice indeed extends the number of rounds for several parameters. We also search the number of rounds of impossible differential characteristics based on the miss-in-the-middle approach. Finally, we make a comparison of all parameters from our results and the observations by Kölbl {\it et al}. Interesting observations are obtained, for instance we find that the optimal parameters with respect to the resistance against differential attacks are not stronger than the original parameter with respect to integral and impossible differential attacks. We also obtain a parameter that is better than the original parameter with respect to security against these four attacks

Improving the Cycle-life of Naphthoquinone-based Active Materials by Their Polymerization for Rechargeable Organic Batteries

AbstractTo increase the cycle-stability of rechargeable batteries using an organic positive-electrode material, we synthesized a polymer from a 5,8-dihydroxy-1,4-naphthoquinone (DHNQ) skeleton, which potentially undergoes a four-electron transfer redox reaction. The polymeric material (PDHNQ) was synthesized by the condensation reaction between DHNQ and formaldehyde under acidic media conditions. The initial capacity of the electrode using the monomer (DHNQ), 193 mAh/g, quickly decayed to 56 mAh/g after 100 cycles. On the other hand, the electrode incorporating the prepared PDHNQ showed the higher initial discharge capacity of 256 mAh/g and a longer cycle-life, retaining about 133 mAh/g after 100 cycles

Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia

Background: Loss of adenomatous polyposis coli (APC) gene function results in constitutive activation of the canonical Wnt pathway and represents the main initiating and rate-limiting event in colorectal tumorigenesis. APC is likely to participate in a wide spectrum of biological functions via its different functional domains and is abundantly expressed in the brain as well as in peripheral tissues. However, the neuronal function of APC is poorly understood. To investigate the functional role of Apc in the central nervous system, we analyzed the neurological phenotypes of Apc 1638T/1638T mice, which carry a targeted deletion of the 3′ terminal third of Apc that does not affect Wnt signaling. Results: A series of behavioral tests revealed a working memory deficit, increased locomotor activity, reduced anxiety-related behavior, and mildly decreased social interaction in Apc 1638T/1638T mice. Apc 1638T/1638T mice showed abnormal morphology of the dendritic spines and impaired long-term potentiation of synaptic transmission in the hippocampal CA1 region. Moreover, Apc 1638T/1638T mice showed abnormal dopamine and serotonin distribution in the brain. Some of these behavioral and neuronal phenotypes are related to symptoms and endophenotypes of schizophrenia. Conclusions: Our results demonstrate that the C-terminus of the Apc tumor suppressor plays a critical role in cognitive and neuropsychiatric functioning. This finding suggests a potential functional link between the C-terminus of APC and pathologies of the central nervous system

Wnt/β-Catenin Signaling Pathway Is a Direct Enhancer of Thyroid Transcription Factor-1 in Human Papillary Thyroid Carcinoma Cells

The Wnt/β-catenin signaling pathway is involved in the normal development of thyroid gland, but its disregulation provokes the appearance of several types of cancers, including papillary thyroid carcinomas (PTC) which are the most common thyroid tumours. The follow-up of PTC patients is based on the monitoring of serum thyroglobulin levels which is regulated by the thyroid transcription factor 1 (TTF-1): a tissue-specific transcription factor essential for the differentiation of the thyroid. We investigated whether the Wnt/β-catenin pathway might regulate TTF-1 expression in a human PTC model and examined the molecular mechanisms underlying this regulation. Immunofluorescence analysis, real time RT-PCR and Western blot studies revealed that TTF-1 as well as the major Wnt pathway components are co-expressed in TPC-1 cells and human PTC tumours. Knocking-down the Wnt/β-catenin components by siRNAs inhibited both TTF-1 transcript and protein expression, while mimicking the activation of Wnt signaling by lithium chloride induced TTF-1 gene and protein expression. Functional promoter studies and ChIP analysis showed that the Wnt/β-catenin pathway exerts its effect by means of the binding of β-catenin to TCF/LEF transcription factors on the level of an active TCF/LEF response element at [−798, −792 bp] in TTF-1 promoter. In conclusion, we demonstrated that the Wnt/β-catenin pathway is a direct and forward driver of the TTF-1 expression. The localization of TCF-4 and TTF-1 in the same area of PTC tissues might be of clinical relevance, and justifies further examination of these factors in the papillary thyroid cancers follow-up

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

Background and purposeThe Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 and published in the Journal of JSICM, [2017; Volume 24 (supplement 2)] https://doi.org/10.3918/jsicm.24S0001 and Journal of Japanese Association for Acute Medicine [2017; Volume 28, (supplement 1)] http://onlinelibrary.wiley.com/doi/10.1002/jja2.2017.28.issue-S1/issuetoc.This abridged English edition of the J-SSCG 2016 was produced with permission from the Japanese Association of Acute Medicine and the Japanese Society for Intensive Care Medicine.MethodsMembers of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ) and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two-thirds (> 66.6%) majority vote of each of the 19 committee members.ResultsA total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J-SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation, and its supporting evidence were also added to each recommendation statement. We conducted meta-analyses for 29 CQs. Thirty-seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for five CQs.ConclusionsBased on the evidence gathered, we were able to formulate Japanese-specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non-specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals

A screening tool to prioritize public health risk associated with accidental or deliberate release of chemicals into the atmosphere

The Chemical Events Working Group of the Global Health Security Initiative has developed a flexible screening tool for chemicals that present a risk when accidentally or deliberately released into the atmosphere. The tool is generic, semi-quantitative, independent of site, situation and scenario, encompasses all chemical hazards (toxicity, flammability and reactivity), and can be easily and quickly implemented by non-subject matter experts using freely available, authoritative information. Public health practitioners and planners can use the screening tool to assist them in directing their activities in each of the five stages of the disaster management cycle