Multiple abnormalities in the skull of a prostitute. An autopsy report (1900)

OBJECTIVE: The study presents and comments on the publication of an autopsy report. CASE REPORT: In 1900 De Blasio published an article entitled "Multiple abnormalities in a prostitute's skull" in the "Journal of Psychiatry, Criminal Anthropology and related sciences". In this work De Blasio related anomalies at the cranial level to the presence of mental pathologies. The skull belonged to a 24-year-old prostitute who died of syphilitic hepatitis. In his article, De Blasio described the life of the woman, after which he gave a macroscopic description of the skull. De Blasio believed that the subject's amoral behavior was caused by the anomalous shape of the subject's skull. CONCLUSION: From the study, it is evident that the school of criminal anthropology influenced De Blasio's autopsy medical practice, and it is interesting to note the interpretation of anthropologists of the time who tried to describe the link between physical and behavioral anomalies

Reconstructing the Density of States by History-Dependent Metadynamics

We present a novel method for the calculation of the energy density of states D(E) for systems described by classical statistical mechanics. The method builds on an extension of a recently proposed strategy that allows the free energy profile of a canonical system to be recovered within a pre-assigned accuracy,[A. Laio and M. Parrinello, PNAS 2002]. The method allows a good control over the error on the recovered system entropy. This fact is exploited to obtain D(E) more efficiently by combining measurements at different temperatures. The accuracy and efficiency of the method are tested for the two-dimensional Ising model (up to size 50x50) by comparison with both exact results and previous studies. This method is a general one and should be applicable to more realistic model systems

RNA denaturation: excluded volume, pseudoknots and transition scenarios

A lattice model of RNA denaturation which fully accounts for the excluded volume effects among nucleotides is proposed. A numerical study shows that interactions forming pseudoknots must be included in order to get a sharp continuous transition. Otherwise a smooth crossover occurs from the swollen linear polymer behavior to highly ramified, almost compact conformations with secondary structures. In the latter scenario, which is appropriate when these structures are much more stable than pseudoknot links, probability distributions for the lengths of both loops and main branches obey scaling with nonclassical exponents.Comment: 4 pages 3 figure

Roles of stiffness and excluded volume in DNA denaturation

The nature and the universal properties of DNA thermal denaturation are investigated by Monte Carlo simulations. For suitable lattice models we determine the exponent c describing the decay of the probability distribution of denaturated loops of length l, $P \sim l^{-c}$. If excluded volume effects are fully taken into account, c= 2.10(4) is consistent with a first order transition. The stiffness of the double stranded chain has the effect of sharpening the transition, if it is continuous, but not of changing its order and the value of the exponent c, which is also robust with respect to inclusion of specific base-pair sequence heterogeneities.Comment: RevTeX 4 Pages and 4 PostScript figures included. Final version as publishe

Specific immunotherapy for allergic rhinitis in Italy: The patients' points of view

Specific immunotherapy (SIT) is the unique causal treatment for allergy, but its use is quite limited. A perspective, cross-sectional telephone interview survey was carried out in Italy to evaluate the characteristics of 500 patients with allergic rhinitis (250 of whom treated with SIT). Relevant differences were found concerning therapeutic management of allergic rhinitis, mainly regarding the use of drugs and co-morbidities. The allergist is the most important consultant who prescribes SIT. This study therefore provides evidence that the course of allergic rhinitis may depend on the therapy prescribed by and the level of allergy awareness of the physician

On the size of knots in ring polymers

We give two different, statistically consistent definitions of the length l of a prime knot tied into a polymer ring. In the good solvent regime the polymer is modelled by a self avoiding polygon of N steps on cubic lattice and l is the number of steps over which the knot ``spreads'' in a given configuration. An analysis of extensive Monte Carlo data in equilibrium shows that the probability distribution of l as a function of N obeys a scaling of the form p(l,N) ~ l^(-c) f(l/N^D), with c ~ 1.25 and D ~ 1. Both D and c could be independent of knot type. As a consequence, the knot is weakly localized, i.e. ~ N^t, with t=2-c ~ 0.75. For a ring with fixed knot type, weak localization implies the existence of a peculiar characteristic length l^(nu) ~ N^(t nu). In the scaling ~ N^(nu) (nu ~0.58) of the radius of gyration of the whole ring, this length determines a leading power law correction which is much stronger than that found in the case of unrestricted topology. The existence of such correction is confirmed by an analysis of extensive Monte Carlo data for the radius of gyration. The collapsed regime is studied by introducing in the model sufficiently strong attractive interactions for nearest neighbor sites visited by the self-avoiding polygon. In this regime knot length determinations can be based on the entropic competition between two knotted loops separated by a slip link. These measurements enable us to conclude that each knot is delocalized (t ~ 1).Comment: 29 pages, 14 figure

Bending-rigidity-driven transition and crumpling-point scaling of lattice vesicles

The crumpling transition of three-dimensional (3D) lattice vesicles subject to a bending fugacity \ensuremath{\rho}=exp(-\ensuremath{\kappa}/${\mathit{k}}_{\mathit{BT}}$) is investigated by Monte Carlo methods in a grand canonical framework. By also exploiting conjectures suggested by previous rigorous results, a critical regime with scaling behavior in the universality class of branched polymers is found to exist for \ensuremath{\rho}\ensuremath{\gtrsim}{\mathrm{\ensuremath{\rho}}}_{\mathit{c}}. For \ensuremath{\rho}{\mathrm{\ensuremath{\rho}}}_{\mathit{c}} the vesicles undergo a first-order transition that has remarkable similarities to the line of droplet singularities of inflated 2D vesicles. At the crumpling point (\ensuremath{\rho}={\mathrm{\ensuremath{\rho}}}_{\mathit{c}}), which has a tricritical character, the average radius and the canonical partition function of vesicles with n plaquettes scale as {\mathit{n}}^{{\ensuremath{\nu}}_{\mathit{c}}} and {\mathit{n}}^{\mathrm{\ensuremath{-}}{\mathrm{\ensuremath{\theta}}}_{\mathit{c}}}, respectively, with {\ensuremath{\nu}}_{\mathit{c}}=0.4825\ifmmode\pm\else\textpm\fi{}0.0015 and {\mathrm{\ensuremath{\theta}}}_{\mathit{c}}=1.78\ifmmode\pm\else\textpm\fi{}0.03. These exponents indicate a new class, distinct from that of branched polymers, for scaling at the crumpling point. \textcopyright{} 1996 The American Physical Society