Capsular Switching in Invasive Neisseria meningitidis, Brazil

During the 1990s, an epidemic of B:4 Neisseria meningitidis infections affected Brazil. Subsequent increase in C:4 disease suggested B→C capsular switching. This study identified B→C switches within the sequence type 32 complex. Substantial disease related to capsular switching emphasizes the need for surveillance of circulating meningococcal strains to optimize disease control

Invasive Neisseria meningitidis Strain Expressing Capsular Polysaccharides W and Y in Brazil

Made available in DSpace on 2015-09-21T17:25:39Z (GMT). No. of bitstreams: 2 license.txt: 1914 bytes, checksum: 7d48279ffeed55da8dfe2f8e81f3b81f (MD5) david_barroso_etal_IOC_2013.pdf: 84101 bytes, checksum: a431715ede4d41e5f442e578b9ade9a6 (MD5) Previous issue date: 2013Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Sistemática Bioquímica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Escola de Medicina. Departamento de Medicina Preventiva. Rio de Janeiro, RJ, Brasil.Secretaria de Saúde do Estado do Rio de Janeiro. Laboratório Central Noel Nutels. Rio de Janeiro, RJ, Brasil.University of Pittsburgh. School of Medicine. Infectious Diseases Epidemiology Research Unit. Graduate School of Public Health. Pittsburgh, Pennsylvania, USA.University of Pittsburgh. School of Medicine. Infectious Diseases Epidemiology Research Unit. Graduate School of Public Health. Pittsburgh, Pennsylvania, USA.University of Pittsburgh. School of Medicine. Infectious Diseases Epidemiology Research Unit. Graduate School of Public Health. Pittsburgh, Pennsylvania, USA.University of Pittsburgh. School of Medicine. Infectious Diseases Epidemiology Research Unit. Graduate School of Public Health. Pittsburgh, Pennsylvania, USA

Three Outbreakcausing Neisseria meningitidis Serogroup C Clones, Brazil

Submitted by sandra infurna ([email protected]) on 2016-01-19T12:41:20Z No. of bitstreams: 1 davi_barroso_etal_IOC_2013.pdf: 385213 bytes, checksum: 87381c26f93fec5eddfa9c1daf62b286 (MD5)Approved for entry into archive by sandra infurna ([email protected]) on 2016-01-19T13:01:33Z (GMT) No. of bitstreams: 1 davi_barroso_etal_IOC_2013.pdf: 385213 bytes, checksum: 87381c26f93fec5eddfa9c1daf62b286 (MD5)Made available in DSpace on 2016-01-19T13:01:33Z (GMT). No. of bitstreams: 1 davi_barroso_etal_IOC_2013.pdf: 385213 bytes, checksum: 87381c26f93fec5eddfa9c1daf62b286 (MD5) Previous issue date: 2013Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Escola de Medicina. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.University of Pittsburgh. Pittsburgh, Pennsylvania, USA.University of Pittsburgh. Pittsburgh, Pennsylvania, USA.University of Pittsburgh. Pittsburgh, Pennsylvania, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Secretaria Estadual de Saúde do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Secretaria Estadual de Saúde do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Cientificalab Laboratory Products and Systems. Rio de Janeiro, RJ, Brasil.Cientificalab Laboratório de Produtos e Sistemas. Rio de Janeiro, RJ, Brasil.Cientificalab Laboratory Products and Systems. Rio de Janeiro, RJ, Brasil.University of Pittsburgh. Pittsburgh, Pennsylvania, USA.During 2003–2012, 8 clusters of meningococcal disease were identified in Rio de Janeiro State, Brazil, all caused by serogroup C Neisseria meningitidis. The isolates were assigned to 3 clonal complexes (cc): cc11, cc32, and cc103. These hyperinvasive disease lineages were associated with endemic disease, outbreaks, and high case-fatality rates

Data from: Evolution and epidemic spread of SARS-CoV-2 in Brazil

Brazil currently has one of the fastest growing SARS-CoV-2 epidemics in the world. Owing to limited available data, assessments of the impact of non-pharmaceutical interventions (NPIs) on virus spread remain challenging. Using a mobility-driven transmission model, we show that NPIs reduced the reproduction number from >3 to 1–1.6 in São Paulo and Rio de Janeiro. Sequencing of 427 new genomes and analysis of a geographically representative genomic dataset identified >100 international virus introductions in Brazil. We estimate that most (76%) of the Brazilian strains fell in three clades that were introduced from Europe between 22 February11 March 2020. During the early epidemic phase, we found that SARS-CoV-2 spread mostly locally and within-state borders. After this period, despite sharp decreases in air travel, we estimated multiple exportations from large urban centers that coincided with a 25% increase in average travelled distances in national flights. This study sheds new light on the epidemic transmission and evolutionary trajectories of SARS-CoV-2 lineages in Brazil, and provide evidence that current interventions remain insufficient to keep virus transmission under control in the country