Bidirectional Associations between Objective Physical Activity and Sleep Patterns in Spanish School Children

We are grateful to Ana Yara Postigo Fuentes for her assistance with the English language. Also, we would like to express our gratitude to the children, parents, teachers and schools for allowing us to carry out this school program, as well as for their involvement and support during the process. Finally, we would also like to express our gratitude to the University of Granada, Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme: Scientific Units of Excellence; Scientific Unit of Excellence on Excercise and Health (UCEES), the Regional Ministry of Economy, Knowledge, Enterprise and Universities, and the European Regional Development Fund (ERDF) [SOMM17/6107/UGR].Physical activity (PA) and sleep contribute to better children’s health. Nonetheless, the bidirectional relationship between both of these health-related factors is unclear when using objective measures. The aims of this study were (1) to describe the PA (light PA and moderate-to-vigorous PA (MVPA) and sleep (duration, latency, and efficiency) patterns of children and compare them with recommendations, and (2) to analyze the bidirectional association between PA levels and sleep patterns in 470 Spanish children according to sex (average age of 8.4 (0.4) years, 51.9% boys). A tri-axial accelerometer and sleep logs were used to measure PA (light PA and MVPA) and sleep patterns (duration, latency, and efficiency) in the children for seven consecutive days. Linear mixed models were conducted to analyze the bidirectional association (PA → sleep and sleep → PA) adjusted for the child, the sex, the school, and the day of observation. The results showed that, overall, the children did not meet the sleep duration recommendations per day. Regarding the bidirectional association, increased light PA and MVPA during the day was related to decreased sleep duration but an improvement in sleep efficiency that night. However, sleep duration and sleep efficiency were only related negatively and positively to light PA the following day, respectively. Regarding sex, light PA was associated with decreased sleep duration in both sexes, although the average value was lower in boys. In addition, light PA was also related only to an improvement in sleep efficiency the same night in both sexes, with girls generally having more efficient sleep. More studies in a representative sample of children that use objective measures to corroborate these results are neededEuropean Regional Development Fund (ERDF) [SOMM17/6107/UGR]

Systemic Minoxidil Accidental Exposure in a Paediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects

This article will be part of the doctoral thesis of the author Manuel Sánchez-Díaz.Oral minoxidil is an approved treatment for high blood pressure which is also used as an off-label drug for alopecia. Knowledge about the effects of systemic minoxidil in the paediatric population is limited. A retrospective case series study of paediatric patients with history of systemic minoxidil intake due to contaminated sets of omeprazole was performed to describe side effects of high dose oral minoxidil intake in children. Twenty patients aged between 2 months and 13 years joined the study. They had received high doses of oral minoxidil (mean dose 0.90 mg/kg/day) during a mean time of 38.3 days. Hypertrichosis appeared in 65%, with a mean latency time of 24.31 days. Treatment time was associated with the appearance of hypertrichosis (p < 0.05). Most common initial zone of hypertrichosis was the face. Systemic effects developed in 15%, with no cases of severe disorders. The present study shows a novel insight into the side effects of high doses of oral minoxidil in children

Heterozygous Arrhythmogenic Cardiomyopathy-desmoplakin Mutation Carriers Exhibit a Subclinical Cutaneous Phenotype with Cell Membrane Disruption and Lack of Intercellular Adhesion

Genetic variants that result in truncation in desmoplakin (DSP) are a known cause of arrhythmogenic cardiomyopathy (AC). In homozygous carriers, the combined involvement of skin and heart muscle is well defined, however, this is not the case in heterozygous carriers. The aim of this work is to describe cutaneous findings and analyze the molecular and ultrastructural cutaneous changes in this group of patients. Four women and eight men with a mean age of 48 ± 14 years were included. Eight met definitive criteria for AC, one was borderline and three were silent carriers. No relevant macroscopic changes in skin and hair were detected. However, significantly lower skin temperature (29.56 vs. 30.97 ◦C, p = 0.036) and higher transepidermal water loss (TEWL) (37.62 vs. 23.95 g m 2 h 1, p = 0.028) were observed compared to sex- and age-matched controls. Histopathology of the skin biopsy showed widening of intercellular spaces and acantholysis of keratinocytes in the spinous layer. Immunohistochemistry showed a strongly reduced expression of DSP in all samples. Trichogram showed regular nodules (thickening) compatible with pseudomonilethrix. Therefore, regardless of cardiac involvement, heterozygous patients with truncation-type variants in DSP have lower skin temperature and higher TEWL, constant microscopic skin involvement with specific patterns and pseudomonilethrix in the trichogram.Andalusian Society of Cardiology with a “beca de Investigación general

Dermatitis artefacta: a disease with difficult diagnosis

La dermatitis artefacta o facticia es una patología de base psicopatológica que usa la piel como modo de expresión, al ser la persona incapaz de verbalizar su malestar interno. Presentamos un caso de esta patología en una mujer de 34 años con lesiones ampollosas en región peribucal de difícil diagnóstico. Este tipo de pacientes acuden en primer lugar a la consulta del dermatólogo constituyendo un reto diagnóstico, ya que niegan cualquier tipo de alteración psíquica. La variabilidad clínica ocasiona gran dificultad diagnóstica y requiere un manejo multidisclipinar y consumo excesivo de recursos y tiempo.Factitious dermatitis is a condition of psychopathological basis using the skin as a means of expression, being the person unable to verbalize their internal unrest. We present a case of this disease in a 34 year old woman with bullous lesions in perioral region are difficult to diagnose. These patients come first consulting dermatologist to constitute a diagnostic challenge because they deny any mental impairment. The clinical variability brings great diagnostic difficulty and requires multidisclipinar handling and excessive consumption of resources and time

Epidermal Barrier Function and Skin Homeostasis in Atopic Dermatitis: The Impact of Age

We would like to thank all the individuals who generously shared their time to participate in this research. The results of this study are part of the PhD work of Trinidad Montero-Vilchez.Skin is damaged in atopic dermatitis (AD) patients. Age is also believed to have a negative effect on epidermal barrier function. The aim of this study was to investigate skin barrier function changes with age in AD patients. A cross-sectional study was conducted including 162 participants, 81 AD patients and 81 healthy volunteers. Skin barrier function parameters, such as transepidermal water loss (TEWL), erythema, temperature, stratum corneum hydration (SCH), pH, and elasticity, were evaluated. Healthy volunteers were evaluated on the volar forearm. AD patients were measured on two regions: on an eczematous lesion on the volar forearm and on a non-involved area 5 cm from the affected area. TEWL was lower on healthy skin than uninvolved AD skin (9.98 vs. 25.51 g center dot m(-2)center dot h(-1), p < 0.001) and AD eczematous lesions (9.98 vs. 28.38 g center dot m(-2)center dot h(-1), p < 0.001). SCH was lower on AD eczematous lesions than uninvolved AD skin (24.23 vs. 39.36 AU, p < 0.001) and healthy skin (24.23 vs. 44.36 AU, p < 0.001). Elasticity was lower on AD eczematous lesions than uninvolved AD skin (0.69 vs. 0.74, p = 0.038) and healthy skin (0.69 vs. 0.77, p = 0.014). A negative correlation was found between age and elasticity in all the population (r = -0.383, p < 0.001). This correlation was stronger in AD patients (r = -0.494, p < 0.001) than in controls (r = -0.266, p = 0.092). After conducting a linear regression model in AD patients adjusted by age, sex, and SCORing Atopic Dermatitis (SCORAD), it was found that elasticity was impaired by an increasing age (beta = -0.004, p < 0.001) and a higher SCORAD (beta = -0.003, p < 0.001). The skin barrier function is impaired by age and AD, reflected mainly in poor elasticity values in older AD patients

Linking of psoriasis with osteopenia and osteoporosis: A cross‑sectional study

Psoriasis is a multisystem disease which has been related to vitamin‑D deficiency through chronic inflammation. This psoriasis‑related inflammatory state and vitamin‑D deficiency may induce bone mineral density loss. The purpose of this study is to assess the relationship of psoriasis with bone mineral density, by comparing psoriatic patients with healthy controls and patients with osteopenia/osteoporosis. Psoriatic patients showed worse hip and lumbar spine bone mineral density levels than healthy controls (P = 0.001) and better levels than osteoporotic patients (P < 0.001). Multivariate analysis demonstrated a negative association of age and a positive association of body mass index in hip bone mineral density in psoriatic patients. Bone mineral density levels in psoriatic patients are situated halfway between healthy controls and patients with osteopenia/osteoporosis. In addition, the higher body mass index in patients with psoriasis appears to confer a protective effect against further development of lower bone mineral density

Manifestaciones cutáneas en pacientes en hemodiálisis periódica por insuficiencia renal crónica

Se ha realizado un estudio transversal con los siguientes objetivos: 1. conocer las enfermedades cutáneas que padecen los pacientes en hemodiálisis periódica por insuficiencia renal crónica. 2. conocer los factores que motivan estas enfermedades, para lo que se ha realizado un anáisis estadístico para evaluar las relaciones entre los parámetros clínicos, de laboratorio y otros propios de la técnica de diálisis. después de completar el estudio en los 114 enfermos que se controlan en el servicio de nefrología del hospital universitario de Granada se ha llegado a las siguientes conclusiones: 1. los pacientes en hemodiálisis periódica por insuficiencia renal crónica presentan una alta prevalencia de enfermedades cutaneas. 2. las manifestaciones cutaneas son independientes del tipo de membrana utilizado en las hemodiálisis. 3. el prurito es muy frecuente. su origen es multifactorial, estando implicados en nuestra serie la hipermagnesemia y la xerosis. 4. la xerosis, en intima relación con el prurito, se relaciona con deficit hidrolipidicos de la superficie cutanea y con la hipoproteinemia. 5. las onicopatias son muy frecuentes. la ausencia de lunula no se relaciona con la anemia y las uñas mitad y mitad aparecen en los pacientes mas deteriorados. 6. el envejecimiento cutaneo precoz es una realidad, estando en nuestra serie, representado por la alta frecuencia de precáncer y cáncer cutaneo, purpura de bateman y arrugas. 7. la dermatosis ampollosa asociada a hemodiálisis y la dermatosis perforante adquirida, aunque bastante caracteristicas de los pacientes en hemodiálisis periódica por insuficiencia renal crónica, son poco frecuentes en nuestra serie.Reducción altaSe ha realizado un estudio transversal con los siguientes objetivos: 1. conocer las enfermedades cutáneas que padecen los pacientes en hemodiálisis periódica por insuficiencia renal crónica. 2. conocer los factores que motivan estas enfermedades, para lo que se ha realizado un anáisis estadístico para evaluar las relaciones entre los parámetros clínicos, de laboratorio y otros propios de la técnica de diálisis. después de completar el estudio en los 114 enfermos que se controlan en el servicio de nefrología del hospital universitario de Granada se ha llegado a las siguientes conclusiones: 1. los pacientes en hemodiálisis periódica por insuficiencia renal crónica presentan una alta prevalencia de enfermedades cutaneas. 2. las manifestaciones cutaneas son independientes del tipo de membrana utilizado en las hemodiálisis. 3. el prurito es muy frecuente. su origen es multifactorial, estando implicados en nuestra serie la hipermagnesemia y la xerosis. 4. la xerosis, en intima relación con el prurito, se relaciona con deficit hidrolipidicos de la superficie cutanea y con la hipoproteinemia. 5. las onicopatias son muy frecuentes. la ausencia de lunula no se relaciona con la anemia y las uñas mitad y mitad aparecen en los pacientes mas deteriorados. 6. el envejecimiento cutaneo precoz es una realidad, estando en nuestra serie, representado por la alta frecuencia de precáncer y cáncer cutaneo, purpura de bateman y arrugas. 7. la dermatosis ampollosa asociada a hemodiálisis y la dermatosis perforante adquirida, aunque bastante caracteristicas de los pacientes en hemodiálisis periódica por insuficiencia renal crónica, son poco frecuentes en nuestra serie.Se ha realizado un estudio transversal con los siguientes objetivos: 1. conocer las enfermedades cutáneas que padecen los pacientes en hemodiálisis periódica por insuficiencia renal crónica. 2. conocer los factores que motivan estas enfermedades, para lo que se ha realizado un anáisis estadístico para evaluar las relaciones entre los parámetros clínicos, de laboratorio y otros propios de la técnica de diálisis. después de completar el estudio en los 114 enfermos que se controlan en el servicio de nefrología del hospital universitario de Granada se ha llegado a las siguientes conclusiones: 1. los pacientes en hemodiálisis periódica por insuficiencia renal crónica presentan una alta prevalencia de enfermedades cutaneas. 2. las manifestaciones cutaneas son independientes del tipo de membrana utilizado en las hemodiálisis. 3. el prurito es muy frecuente. su origen es multifactorial, estando implicados en nuestra serie la hipermagnesemia y la xerosis. 4. la xerosis, en intima relación con el prurito, se relaciona con deficit hidrolipidicos de la superficie cutanea y con la hipoproteinemia. 5. las onicopatias son muy frecuentes. la ausencia de lunula no se relaciona con la anemia y las uñas mitad y mitad aparecen en los pacientes mas deteriorados. 6. el envejecimiento cutaneo precoz es una realidad, estando en nuestra serie, representado por la alta frecuencia de precáncer y cáncer cutaneo, purpura de bateman y arrugas. 7. la dermatosis ampollosa asociada a hemodiálisis y la dermatosis perforante adquirida, aunque bastante caracteristicas de los pacientes en hemodiálisis periódica por insuficiencia renal crónica, son poco frecuentes en nuestra serie. {09}Univ. de Granada, Departamento de Medicina. 199

Tándem : didáctica de la educación física

Resumen basado en el de la revista. Monográfico titulado: Actividad física y saludSe pretende educar para la salud desde el área de educación física en la escuela. El sistema educativo trata la educación para la salud como un tema transversal que debe ser desarrollado por todas las áreas curriculares. El área de educación física presenta grandes posibilidades concretadas en un modelo específico de intervención, con el que se presentan una serie de reflexiones sobre la percepción que la sociedad en general tiene de la actividad física y su relación con la salud. La educación para la salud pretende desarrollar procedimientos y actitudes para que el alumno consiga su mayor grado de bienestar, adquiera conocimientos y habilidades básicas y además establezca hábitos, valores, conductas y prácticas saludables para su vida presente y futura con libre autonomía.CataluñaBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

E-patients in Oncology: a corpus-based characterization of medical terminology in an online cancer forum

This study aimed to characterize medical terms in an online cancer forum, with particular focus on specialization and semantic features. A three-step analysis was carried out on a 60-million-word corpus to detect and characterize the most typical medical terms used in a cancer forum by means of (1) keywords contrastive, (2) co-text-guided, and (3) semantic analyses. More than half of the 1000 words analysed were medical terms according to the co-text-guided analysis carried out. Most of them (73%) were dictionary-defined medical terms, followed by co-text-defined terms (9%) and medical initialisms (8.5%). The semantic analysis showed a higher number of terms within the fields of Anatomy, Treatment, Hospital and Symptoms. Our findings suggest that medical terms are commonly used in cancer forums, especially to share e-patients’ concerns about treatment, symptoms and hospital environment. The method followed is efficient and could be applied in future studies. Altogether, this article contributes to characterizing medical terms used by e-patients in online cancer forum