Measuring Harmonic Tension in Post-Tonal Repertoire

Despite the large body of research that has examined tonal and atonal harmonies to our perception of tension, there is no work that describes or explores the perception of post-tonal chords, but more specifically, chords that contain both tonal and post-tonal features. This article applies the concept of calculating the total amount of voice-leading movement, to examine its relationship to our perception of tension and release. To do this, three neoclassical pieces are selected to analyze the relationship between theoretical and perceived tension. The findings suggest that in addition to calculating the horizontal motion between harmonies, physical and acoustical factors play a critical role in relating theoretical to perceived tension. This approach is adaptable to other neoclassical works and in addition, this study could have implications in other musical fields such as performance practices and analyzing formal functions in post-tonal repertoire

Towards a Hybrid Theoretical Model for Neoclassical Music: Schenkerian, Neo-Riemannian and Pitch-Class Set Theories

This thesis explores the necessity for theoretical hybridity as an analytical tool to overcome the challenges faced in works that embody both tonal and post-tonal elements. This hybridised model responds to the lack of a single theory that accounts for neoclassical harmonic practices: Schenkerian methods prove useful in drawing out different structural levels whilst Neo-Riemannian theory recognises non-traditional chordal relationships, and the application of set theory can fill the gaps where none of the aforementioned methods are applicable. Although some have responded to this problem by extending the individual methods’ application (e.g. Baker, 1990) or by simultaneously using more than one analytical approach (e.g. Cinnamon, 1993; Pople, 1989), none of these authors have fully integrated the methods into one unified approach. And despite the large body of research that has examined perceptions of tension in tonal (Lerdahl and Jackendoff, 1983) and atonal (Dibben 1999) harmonies, there is no work that explores the perception of post-tonal harmonies. The project begins with an appraisal of literature surrounding the conceptual issues around hybridity within music and various existing combined approaches to analyse music. This is then followed by the methodology – Voice-leading (VL) Reduction, Rhythmic Segmentation and Calculation, Beat-Class BC Set Theory, and an experimental enquiry into the measurement of post-tonal harmonic tension – exemplified through selected sections from a small number of studies: Mathis der Mahler by Paul Hindemith, “Tanec Loutek” (No. 5) from Puppets by Bohuslav Martinu, Passacaglia by Aaron Copland, Violin Concerto in D Minor by Ralph Vaughan Williams, Sonata No. 3 by George Enescu, Sonatine by Maurice Ravel, Piano Sonata No. 2 by Paul Hindemith, and Concerto for Piano and Wind Instruments by Igor Stravinsky. The application of the model is then carried out through two complete case studies: First Movement of Hindemith’s Second Piano Sonata, and the first movement of Stravinsky’s Concerto for Piano and Wind Instruments. My analyses first perform the three approaches separately, before synthesising the results. To determine which pitch collections will be examined, the music is segmented into its core beat classes. My voice-leading analysis overlays three systems (treble and bass voice-leading reductions, pitch collection), describing the transformation between pitch collections. Line graphs chart the voice-leading movement between pitch collections against the treble voice-leading reduction, capturing the correlation between the melodic and harmonic factors. The rhythmic-phrase analysis is then integrated into the diagrams as a set of tables detailing its different hierarchies. The results reveal the correlation between middleground layers and phrase design, and between rhythmic features and other musical parameters. In all, the detailed examination of different musical parameters reveals that this hybridised model enables a comprehensive structural narrative for each piece, filling in existing theories’ lacunae by revealing a more detailed explanation of the harmonic content, an enriched middleground chart, and its articulation in other musical parameters. This thus reveals the model’s potential to revolutionise analytical approaches to neoclassical compositions and to understand their compositional techniques. Current findings also indicate that these graphical representations account for all types of chords as pitch collections and illustrate the relationship between each vertical sonority; that the aggregated voice-leading movement (AVL) – the total amount of voice-leading movement – can better account for the identification of post-tonal closure, and the results from the empirical study suggest that external factors need to be accounted for along with the AVL in order to relate theoretical to perceived tension. This research will therefore not only contribute to post-tonal theory and analysis but also to music perception, to understand better how we conceive harmonic tension in music that embodies tonal and atonal elements

Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain

<p>Abstract</p> <p>Background</p> <p>Morphine consumption can vary widely between individuals even for identical surgical procedures. As mu-opioid receptor (OPRM1) is known to modulate pain perception and mediate the analgesic effects of opioid compounds in the central nervous system, we examined the influence of two OPRM polymorphisms on acute post-operative pain and morphine usage in women undergoing elective caesarean delivery.</p> <p>Results</p> <p>Data on self-reported pain scores and amount of total morphine use according to patient-controlled analgesia were collected from 994 women from the three main ethnic groups in Singapore. We found statistically significant association of the OPRM 118A>G with self-administered morphine during the first 24-hour postoperative period both in terms of total morphine (p = 1.7 × 10^-5) and weight-adjusted morphine (p = 6.6 × 10^-5). There was also significant association of this OPRM variant and time-averaged self-rated pain scores (p = 0.024). OPRM 118G homozygotes used more morphine and reported higher pain scores than 118A carriers. Other factors which influenced pain score and morphine usage include ethnicity, age and paying class.</p> <p>Conclusion</p> <p>Our results suggest that ethnicity and OPRM 118A>G genotype are independent and significant contributors to variation in pain perception and postoperative morphine use in patients undergoing cesarean delivery.</p

ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes

SummaryESCRT complexes form the main machinery driving protein sorting from endosomes to lysosomes. Currently, the picture regarding assembly of ESCRTs on endosomes is incomplete. The structure of the conserved heterotrimeric ESCRT-I core presented here shows a fan-like arrangement of three helical hairpins, each corresponding to a different subunit. Vps23/Tsg101 is the central hairpin sandwiched between the other subunits, explaining the critical role of its “steadiness box” in the stability of ESCRT-I. We show that yeast ESCRT-I links directly to ESCRT-II, through a tight interaction of Vps28 (ESCRT-I) with the yeast-specific zinc-finger insertion within the GLUE domain of Vps36 (ESCRT-II). The crystal structure of the GLUE domain missing this insertion reveals it is a split PH domain, with a noncanonical lipid binding pocket that binds PtdIns3P. The simultaneous and reinforcing interactions of ESCRT-II GLUE domain with membranes, ESCRT-I, and ubiquitin are critical for ubiquitinated cargo progression from early to late endosomes

Emergency Service Workers: The Role of Policy and Management in (Re)shaping Wellbeing for Emergency Service Workers

This article examines the impact of psychosocial safety climate (PSC) levels and strength on the job stress and psychological distress of emergency services workers within street level bureaucracies (SLBs). The reason for the research is because the nature of their work and organizational context pre-disposes them to elevated level of psychological distress, and places them at a higher risk of subsequent debilitating physical and mental diseases, which is a cost borne by employees, their families, friends, SLBs, and taxpayers. Survey data was obtained from 274 emergency services workers (including police, and paramedics), nested within 43 workgroups, in Australia. Multilevel regression indicated that lower levels of PSC were associated with higher levels of job stress and psychological distress. Also, PSC strength had a partial moderating effect. The findings justify governments intervening legislatively to ensure SLBs’ take responsibility for ensuring a supportive PSC to mitigates the impact of exposure to workplace trauma

Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.

INTRODUCTION AND OBJECTIVE: Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study factors of susceptibility towards development of T2DM, which are poorly understood. Emerging key players in T2DM pathophysiology such as adverse oxidative stress and inflammatory responses could be among possible mechanisms that predispose FDRTs to develop T2DM. Here, we aimed to examine the role of oxidative stress and inflammatory responses as mediators of this excess risk by studying dynamic postprandial responses in FDRTs. RESEARCH DESIGN AND METHODS: In this open-label case-control study, we recruited normoglycemic men with (n=9) or without (n=9) a family history of T2DM. We assessed plasma glucose, insulin, lipid profile, cytokines and F2-isoprostanes, expression levels of oxidative and inflammatory genes/proteins in circulating mononuclear cells (MNC), myotubes and adipocytes at baseline (fasting state), and after consumption of a carbohydrate-rich liquid meal or insulin stimulation. RESULTS: Postprandial glucose and insulin responses were not different between groups. Expression of oxidant transcription factor NRF2 protein (p<0.05 for myotubes) and gene (pgroup=0.002, ptime×group=0.016), along with its target genes TXNRD1 (pgroup=0.004, ptime×group=0.007), GPX3 (pgroup=0.011, ptime×group=0.019) and SOD-1 (pgroup=0.046 and ptime×group=0.191) was upregulated in FDRT-derived MNC after meal ingestion or insulin stimulation. Synergistically, expression of target genes of inflammatory transcription factor nuclear factor kappa B such as tumor necrosis factor alpha (pgroup=0.001, ptime×group=0.007) was greater in FDRT-derived MNC than in non-FDRT-derived MNC after meal ingestion or insulin stimulation. CONCLUSIONS: Our findings shed light on how heredity of T2DM confers increased susceptibility to oxidative stress and inflammation. This could provide early insights into the underlying mechanisms and future risk of FDRTs for developing T2DM and its associated complications

Cell-surface sensors for real-time probing of cellular environments

Author Manuscript 2012 August 1.The ability to explore cell signalling and cell-to-cell communication is essential for understanding cell biology and developing effective therapeutics. However, it is not yet possible to monitor the interaction of cells with their environments in real time. Here, we show that a fluorescent sensor attached to a cell membrane can detect signalling molecules in the cellular environment. The sensor is an aptamer (a short length of single-stranded DNA) that binds to platelet-derived growth factor (PDGF) and contains a pair of fluorescent dyes. When bound to PDGF, the aptamer changes conformation and the dyes come closer to each other, producing a signal. The sensor, which is covalently attached to the membranes of mesenchymal stem cells, can quantitatively detect with high spatial and temporal resolution PDGF that is added in cell culture medium or secreted by neighbouring cells. The engineered stem cells retain their ability to find their way to the bone marrow and can be monitored in vivo at the single-cell level using intravital microscopy.National Institutes of Health (U.S.) (Grant HL097172)National Institutes of Health (U.S.) (Grant HL095722)National Institutes of Health (U.S.) (Grant DE019191)National Institutes of Health (U.S.) (Grant NIAID 5RC1AI086152)Charles A. Dana FoundationAmerican Heart Association (Grant 0970178N)National Science Foundation (U.S.) (Graduate Fellowship

A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2

Blood levels of adiponectin, an adipocyte-secreted protein correlated with metabolic and cardiovascular risks, are highly heritable. Genome-wide association (GWA) studies for adiponectin levels have identified 14 loci harboring variants associated with blood levels of adiponectin. To identify novel adiponectin-associated loci, particularly those of importance in East Asians, we conducted a meta-analysis of GWA studies for adiponectin in 7827 individuals, followed by two stages of replications in 4298 and 5954 additional individuals. We identified a novel adiponectin-associated locus on chromosome 10 near WDR11-FGFR2 (P = 3.0 × 10−14) and provided suggestive evidence for a locus on chromosome 12 near OR8S1-LALBA (P = 1.2 × 10−7). Of the adiponectin-associated loci previously described, we confirmed the association at CDH13 (P = 6.8 × 10−165), ADIPOQ (P = 1.8 × 10−22), PEPD (P = 3.6 × 10−12), CMIP (P = 2.1 × 10−10), ZNF664 (P = 2.3 × 10−7) and GPR109A (P = 7.4 × 10−6). Conditional analysis at ADIPOQ revealed a second signal with suggestive evidence of association only after conditioning on the lead SNP (Pinitial = 0.020; Pconditional = 7.0 × 10−7). We further confirmed the independence of two pairs of closely located loci (<2 Mb) on chromosome 16 at CMIP and CDH13, and on chromosome 12 at GPR109A and ZNF664. In addition, the newly identified signal near WDR11-FGFR2 exhibited evidence of association with triglycerides (P = 3.3 × 10−4), high density lipoprotein cholesterol (HDL-C, P = 4.9 × 10−4) and body mass index (BMI)-adjusted waist–hip ratio (P = 9.8 × 10−3). These findings improve our knowledge of the genetic basis of adiponectin variation, demonstrate the shared allelic architecture for adiponectin with lipids and central obesity and motivate further studies of underlying mechanisms

Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 10(-8). Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers.COGS project is funded through a European Commission's Seventh Framework Programme grant (agreement number 223175 ] HEALTH ]F2 ]2009 ]223175). The CIMBA data management and data analysis were supported by Cancer Research.UK grants 12292/A11174 and C1287/A10118. The Ovarian Cancer Association Consortium is supported by a grant from the Ovarian Cancer Research Fund thanks to donations by the family and friends of Kathryn Sladek Smith (PPD/RPCI.07). The scientific development and funding for this project were in part supported by the US National Cancer Institute GAME ]ON Post ]GWAS Initiative (U19 ]CA148112). This study made use of data generated by the Wellcome Trust Case Control consortium. Funding for the project was provided by the Wellcome Trust under award 076113. The results published here are in part based upon data generated by The Cancer Genome Atlas Pilot Project established by the National Cancer Institute and National Human Genome Research Institute (dbGap accession number phs000178.v8.p7). The cBio portal is developed and maintained by the Computational Biology Center at Memorial Sloan ] Kettering Cancer Center. SH is supported by an NHMRC Program Grant to GCT. Details of the funding of individual investigators and studies are provided in the Supplementary Note. This study made use of data generated by the Wellcome Trust Case Control consortium, funding for which was provided by the Wellcome Trust under award 076113. The results published here are, in part, based upon data generated by The Cancer Genome Atlas Pilot Project established by the National Cancerhttp://dx.doi.org/10.1038/ng.3185This is the Author Accepted Manuscript of 'Identification of six new susceptibility loci for invasive epithelial ovarian cancer' which was published in Nature Genetics 47, 164–171 (2015) © Nature Publishing Group - content may only be used for academic research