92 research outputs found
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels
Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in up to 69,414 East Asian individuals from 24 studies with participants from Japan, the Philippines, Korea, China, Singapore, and Taiwan. These meta-analyses identified (P < 5 × 10-8) three novel loci associated with HDL-C near CD163-APOBEC1 (P = 7.4 × 10-9), NCOA2 (P = 1.6 × 10-8), and NID2-PTGDR (P = 4.2 × 10-8), and one novel locus associated with TG near WDR11-FGFR2 (P = 2.7 × 10-10). Conditional analyses identified a second signal near CD163-APOBEC1. We then combined results from the East Asian meta-analysis with association results from up to 187,365 European individuals from the Global Lipids Genetics Consortium in a trans-ancestry meta-analysis. This analysis identified (log10Bayes Factor ≥6.1) eight additional novel lipid loci. Among the twelve total loci identified, the index variants at eight loci have demonstrated at least nominal significance with other metabolic traits in prior studies, and two loci exhibited coincident eQTLs (P < 1 × 10-5) in subcutaneous adipose tissue for BPTF and PDGFC. Taken together, these analyses identified multiple novel lipid loci, providing new potential therapeutic targets
Analysis of High-Resolution FTIR Spectrum of the ν6Band of H13COOH
10.1006/jmsp.1998.7776Journal of Molecular Spectroscopy1942203-205JMOS
Firm-specificity and organizational learning-related scale on investment in internal human capital for open source software adoption
10.1145/1355238.1355244SIGMIS CPR 2008 - Proceedings of the 2008 ACM SIGMIS CPR Conference: Refilling the Pipeline: Meeting the Renewed Demand for Information Technology Workers22-2
Hybrid Bioprocess Modelling of an Industrially Relevant Pharmaceutical Production Process: Parameterisation, Sensitivity, and Robustness Analysis with Modelica
Proceedings of the Hawaii International Conference on System Sciences372841-2850PHIS
Real options from RFID adoption: The role of institutions and managerial mindfulness
ICIS 2008 Proceedings - Twenty Ninth International Conference on Information System
Effects of cultural cognitive styles on users' evaluation of website complexity
International Conference on Information Systems, ICIS 201243089-310
An evaluation of novice end-user computing performance: Data modeling, query writing, and comprehension
10.1002/asi.20178Journal of the American Society for Information Science and Technology568843-853AISJ
Value co-creation with customers through design toolkits: The importance of preference fit and psychological ownership
19th European Conference on Information Systems, ECIS 201
Spontaneous virtual teams: Improving organizational performance through information and communication technology
10.1016/j.bushor.2013.01.003Business Horizons563361-375BHOR
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