3,805 research outputs found
The evolving preprint landscape:Introductory report for the Knowledge Exchange working group on preprints
Measurement of pilot describing functions in single-controller multiloop tasks
Measurement of pilot describing functions in single controller multiloop task
CLINICAL OUTCOMES ASSOCIATED WITH TIME TO ANTIMICROBIAL THERAPY CHANGE FROM VANCOMYCIN TO DAPTOMYCIN IN STAPHYLOCOCCAL BACTEREMIA
Background: Staphylococcus aureus is an aerobic, Gram positive commensal organism that is capable of causing a wide spectrum of disease. This study contributes to previously published literature regarding daptomycin versus vancomycin use in S. aureus bacteremia (SAB).
Methods: Adult patients admitted between 2010 and 2014, billed for ICD-9 code V09.0, 038.11, 038.12, 041.11, or 041.12, and received vancomycin and daptomycin were included in this retrospective analysis. Patients were stratified by time to change in antibiotics from vancomycin to daptomycin to the early switch (1-3 days), intermediate switch (4-7 days), or late switch (8 days or later) group. The primary outcome was treatment failure defined as 30-day recurrence, 60-day all-cause mortality, and 90-day all-cause readmission.
Results: 193 patients were enrolled in the final cohort. The overall treatment failure rate was 18% with no differences between early switch, intermediate switch, and late switch (P=0.72) groups. Independent predictors of treatment success were length of stay (OR=1.035) and time to positive culture (OR=0.961).
Conclusions: Results of this study did not demonstrate a difference in treatment failure based on time to switch from vancomycin to daptomycin. Future research should focus on optimizing use of vancomycin and daptomycin and medical management of SAB
The attachments of ‘autonomous’ vehicles
The ideal of the self-driving car replaces an error-prone human with an infallible, artificially intelligent driver. This narrative of autonomy promises liberation from the downsides of automobility, even if that means taking control away from autonomous, free-moving individuals. We look behind this narrative to understand the attachments that so-called ‘autonomous’ vehicles (AVs) are likely to have to the world. Drawing on 50 interviews with AV developers, researchers and other stakeholders, we explore the social and technological attachments that stakeholders see inside the vehicle, on the road and with the wider world. These range from software and hardware to the behaviours of other road users and the material, social and economic infrastructure that supports driving and self-driving. We describe how innovators understand, engage with or seek to escape from these attachments in three categories: ‘brute force’, which sees attachments as problems to be solved with more data, ‘solve the world one place at a time’, which sees attachments as limits on the technology’s reach and ‘reduce the complexity of the space’, which sees attachments as solutions to the problems encountered by technology developers. Understanding attachments provides a powerful way to anticipate various possible constitutions for the technology
Climate constrains the evolutionary history and biodiversity of crocodylians
The fossil record of crocodylians and their relatives (pseudosuchians) reveals a rich evolutionary history, prompting questions about causes of long-term decline to their present-day low biodiversity. We analyse climatic drivers of subsampled pseudosuchian biodiversity over their 250 million year history, using a comprehensive new data set. Biodiversity and environmental changes correlate strongly, with long-term decline of terrestrial taxa driven by decreasing temperatures in northern temperate regions, and biodiversity decreases at lower latitudes matching patterns of increasing aridification. However, there is no relationship between temperature and biodiversity for marine pseudosuchians, with sea-level change and post-extinction opportunism demonstrated to be more important drivers. A ‘modern-type' latitudinal biodiversity gradient might have existed throughout pseudosuchian history, and range expansion towards the poles occurred during warm intervals. Although their fossil record suggests that current global warming might promote long-term increases in crocodylian biodiversity and geographic range, the 'balancing forces' of anthropogenic environmental degradation complicate future predictions
The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice.
The PICALM (CALM) gene, whose product is involved in clathrin-mediated endocytosis, has been identified in two recurring chromosomal translocations, involving either MLL or MLLT10 (AF10). We developed a mouse model of CALM-AF10(+) leukemia to examine the hypothesis that disruption of endocytosis contributes to leukemogenesis. Exclusion of the C-terminal portion of CALM from the fusion protein, which is required for optimal binding to clathrin, resulted in the development of a myeloproliferative disease, whereas inclusion of this domain led to the development of acute myeloid leukemia and changes in gene expression of several cancer-related genes, notably Pim1 and Crebbp. Nonetheless, the development of leukemia could not be attributed directly to interference with endocytosis or consequential changes in proliferation and signaling. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin. Using fluorescence resonance energy transfer analysis, we show that CALM-AF10 has a propensity to homo-oligomerize, raising the possibility that the function of endocytic proteins involved in chimeric fusions may be to provide dimerization properties, a recognized mechanism for unleashing oncogenic properties of chimeric transcription factors, rather than disrupting the internalization of growth factor receptors
The dynamic characteristics of human skeletal muscle modeled from surface stimulation
Dynamic characteristics of human skeletal muscle modeled from surface stimulatio
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Stochastic parameterization: uncertainties from convection
In 2005, the ECMWF held a workshop on stochastic parameterisation, at which the convection was seen as being
a key issue. That much is clear from the working group reports and particularly the statement from working group
1 that “it is clear that a stochastic convection scheme is desirable”. The present note aims to consider our current
status in comparison with some of the issues raised and hopes expressed in that working group report
A Novel Longitudinal Mode in the Coupled Quantum Chain Compound KCuF3
Inelastic neutron scattering measurements are reported that show a new
longitudinal mode in the antiferromagnetically ordered phase of the spin-1/2
quasi-one-dimensional antiferromagnet KCuF3. This mode signals the cross-over
from one-dimensional to three-dimensional behavior and indicates a reduction in
the ordered spin moment of a spin-1/2 antiferromagnet. The measurements are
compared with recent quantum field theory results and are found to be in
excellent agreement. A feature of the data not predicted by theory is a damping
of the mode by decay processes to the transverse spin-wave branches.Comment: 9 pages of text plus 4 postscript figures (1 color
Evolution of Hard X-Ray Spectra Along the Branches in Cir X-1
Using the data from the PCA and HEXTE on board the RXTE satellite, we
investigate the evolution of the 3-200 keV spectra of the peculiar low mass
X-ray binary (LMXB) Cir X-1 along the branches on its hardness-intensity
diagram (HID) from the vertical horizontal branch (VHB), through the horizontal
horizontal branch (HHB) and normal branch (NB), to the flaring branch (FB). We
detect a power-law hard component in the spectra. It is found that the derived
photon indices () of the power-law hard component are correlated with
the position on the HID. The power-law component dominates the X-ray emission
of Cir X-1 in the energy band higher than keV. The fluxes of the
power-law component are compared with those of the bremsstrahlung component in
the spectra. A possible origin of the power-law hard component is discussed.Comment: 14 pages, 5 figures, ApJ Letter accepte
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