The effect of manganese oxide on the sinterability of hydroxyapatite

The sinterability of manganese oxide (MnO2) doped hydroxyapatite (HA) ranging from 0.05 to 1 wt% was investigated. Green samples were prepared and sintered in air at temperatures ranging from 1000 to 1400 °C. Sintered bodies were characterized to determine the phase stability, grain size, bulk density, hardness, fracture toughness and Young's modulus. XRD analysis revealed that the HA phase stability was not disrupted throughout the sintering regime employed. In general, samples containing less than 0.5 wt% MnO2 and when sintered at lower temperatures exhibited higher mechanical properties than the undoped HA. The study revealed that all the MnO2-doped HA achieved >99% relative density when sintered at 1100–1250 °C as compared to the undoped HA which could only attained highest value of 98.9% at 1150 °C. The addition of 0.05 wt% MnO2 was found to be most beneficial as the samples exhibited the highest hardness of 7.58 GPa and fracture toughness of 1.65 MPam1/2 as compared to 5.72 GPa and 1.22 MPam1/2 for the undoped HA when sintered at 1000 °C. Additionally, it was found that the MnO2-doped samples attained E values above 110 GPa when sintered at temperature as low as 1000 °C if compared to 1050 °C for the undoped HA

Where do They Head for University Studies? The University Destinations of Chinese IBDP Graduates: A Study of the International Baccalaureate Diploma Program in China

Paper PresentationConference theme: Educational Reform and Social Change: East-West DialogueOver the last decade, the number of IB programs adopted by schools around the world has dramatically increased by almost 400% (IB, 2009; Lee et al., in-press). In recent years China has also evidenced an impressive gain in the number of schools adopting IB programs in general and the DP in particular. Specifically, as of 2011, there were 50 IB schools authorized for the implementation of the DP in China. Of these, 43 schools have been authorized since 2003 (IB, 2012), illustrating the fast growth of IBDP schools in China in recent years. Despite such fast growth (and by implication, popularity) of the IBDP schools in China, empirical studies exploring the impact of Chinese IBDP students’ learning outcomes in terms of their university matriculation to foreign universities seems to be almost nonexistent. With this in mind, the primary goal of this proposal is to document the patterns of university destination of IBDP graduates in China over time. To this end, our analysis centers on the following overarching question: Where have Chinese students who previously graduated from the 50 IB schools been educated? Alongside the focus of the main question, we seek answers to more specific questions: Are there any trends in their university destinations in terms of geographical region or university prestige (by ranking)? Are there any significant differences in students’ enrolment in foreign universities before or after the 50 IB schools’ adoption of the DP (in the case that the 50 IB schools implemented different international programs other than the DP before they adopted the IB)? Does the adoption of the DP contribute to the growth (rate) of DP graduates enrolled in foreign universities? To investigate these questions, we adopt a theoretical framework from research of international student mobility. Specifically, we focus on internal and external forces (Altbach, Reisberg & Rumbley, 2009; Li & Bray, 2007) that influence IB graduates’ international flow in terms of university destination. We employ a sequential explanatory design (Creswell, Plano, Gutmann, & Hanson, 2003). As part of the mixed-methods research project, we plan to collect longitudinal data on DP graduates’ destinations for university study since the adoption of the DP. A series of quantitative analysis (e.g., descriptive trend analysis, pre/post comparison “before and after” the 50 IB schools’ adoption of the DP, and longitudinal analysis using piecewise modeling) will be employed to determine trends and patterns in terms of university matriculation of the 50 schools over time. As first of its kind, this study will evidence the impact of the DP on student preparation for university studies abroad. In addition, the dataset may be employed for broader purposes (e.g., program development or evaluation) within the IB and the community of schools in China or East Asian countries.published_or_final_versio

In vivo effects on intron retention and exon skipping by the U2AF large subunit and SF1/BBP in the nematode Caenorhabditis elegans

The in vivo analysis of the roles of splicing factors in regulating alternative splicing in animals remains a challenge. Using a microarray-based screen, we identified a Caenorhabditis elegans gene, tos-1, that exhibited three of the four major types of alternative splicing: intron retention, exon skipping, and, in the presence of U2AF large subunit mutations, the use of alternative 3' splice sites. Mutations in the splicing factors U2AF large subunit and SF1/BBP altered the splicing of tos-1. 3' splice sites of the retained intron or before the skipped exon regulate the splicing pattern of tos-1. Our study provides in vivo evidence that intron retention and exon skipping can be regulated largely by the identities of 3' splice sites

Local infiltration analgesia versus femoral nerve block in total knee arthroplasty: A meta-analysis

AbstractIntroductionLocal infiltration analgesia (LIA) and femoral nerve block (FNB) are both used for the pain management after total knee arthroplasty (TKA). Controversy still remains regarding the optimal technique for pain relief in patients undergoing TKA. The purpose of this meta-analysis was to compare the analgesia achieved with LIA and the one from FNB following TKA.HypothesisLIA achieves better pain control than FNB in patients with TKA.MethodsDatabases, including Pubmed, EMBASE, the Cochrane Library and Web of Science were comprehensively searched to identify studies comparing LIA with FNB for patients with TKA. Two reviewers independently selected trials, extracted data, and assessed the methodological qualities of included studies. Data were analyzed by RevMan 5.2.ResultsNine RCTs involving 782 patients were included. LIA achieved more rapid pain relief (VAS) at 6h postoperatively [SMD6h=−0.92, 95% CI (−1.38, −0.47)] than FNB. There were no significant differences at 24h and 48h [SMD24h=−0.03, 95% CI (−0.46, 0.40); SMD48h=0.28, 95% CI (−0.35, 0.91)], VAS with activity at 24h and 48h [SMD6h=−0.54, 95% CI (−1.62, 0.54); SMD24h=−0.22, 95% CI (−1.41, 0.96); SMD48h=−0.08, 95% CI (−0.52, 0.69)], opioid consumption at 24h and 48h [SMD24h=−0.24, 95% CI (−0.82, 0.34); SMD48h=0.15, 95% CI (0.25, 0.54)] and length of hospital stay [MD=−0.52, 95% CI (−1.13, 0.09)].DiscussionLIA may be the better choice in the pain management of TKA for it could achieve fast pain relief and is easier to perform than FNB for patients with TKA.Level of evidenceLevel II, meta-analysis and systematic review

Flexural behaviour of hybrid FRP-concrete-steel double skin tubular members

This paper presents the results of an experimental study on the flexural behavior of a new type of hybrid FRP-concrete-steel member as well as results from a corresponding theoretical model based on the plane section assumption and the fiber element approach. This new type of hybrid member is in the form of a double-skin tube, composed of a steel inner tube and an FRP outer tube with a concrete infill between the two tubes, and may be employed as columns or beams. The parameters examined in this study include the section configuration, the concrete strength, and the thicknesses of the steel tube and the FRP tube, respectively. The results presented in this paper show that these hybrid beams have a very ductile response because the compressive concrete is confined by the FRP tube and the steel tube provides ductile longitudinal reinforcement. The beams\u27 flexural response, including the flexural stiffness, ultimate load, and cracking, can be substantially improved by shifting the inner steel tube toward the tension zone or by providing FRP bars as additional longitudinal reinforcement. The predictions from the theoretical model are in reasonably close agreement with the test results. Differences between the test and predicted results arise from factors not considered in the theoretical model, including the existence of a strain gradient in the confined concrete, concentrations of cracks and the slips between the concrete and the two tubes; these are issues to be accounted for in the development of a more accurate model in the future

Comparative bactericidal activities of daptomycin, glycopeptides, linezolid and tigecycline against blood isolates of Gram-positive bacteria in Taiwan

ABSTRACTIn-vitro MICs and minimum bactericidal concentrations (MBCs) of daptomycin, linezolid, tigecycline, vancomycin and teicoplanin against Gram-positive bacteria were determined using the broth microdilution method for ten blood isolates each of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), including two vancomycin-intermediate S. aureus (VISA), vancomycin-resistant Enterococcus faecium and Enterococcus faecalis. One strain of VISA was tested in a time-kill synergism assay of daptomycin combined with oxacillin, imipenem, rifampicin and isepamicin. Daptomycin showed excellent in-vitro bactericidal activity against all the isolates tested, with no tolerance or synergism effects when combined with other agents, except with rifampicin against VISA. Vancomycin had better bactericidal activity against MRSA and MSSA than did teicoplanin. Linezolid had the poorest bactericidal activity against the isolates tested, with 100% tolerance by the MSSA and VRE isolates, and 80% tolerance by the MRSA isolates. Tolerance towards tigecycline was exhibited by 40% of the MRSA isolates, 100% of the MSSA and vancomycin-resistant E. faecalis isolates, and 90% of the vancomycin-resistant E. faecium isolates

Single-molecule detection of α-Synuclein oligomers in Parkinson's disease patients using nanopores

α-Synuclein (α-Syn) is an intrinsically disordered protein whose aggregation in the brain has been significantly implicated in Parkinson's disease (PD). Beyond the brain, oligomers of α-Synuclein are also found in cerebrospinal fluid (CSF) and blood, where the analysis of these aggregates may provide diagnostic routes and enable a better understanding of disease mechanisms. However, detecting α-Syn in CSF and blood is challenging due to its heterogeneous protein size and shape, and low abundance in clinical samples. Nanopore technology offers a promising route for the detection of single proteins in solution; however, the method often lacks the necessary selectivity in complex biofluids, where multiple background biomolecules are present. We address these limitations by developing a strategy that combines nanopore-based sensing with molecular carriers that can specifically capture α-Syn oligomers with sizes of less than 20 nm. We demonstrate that α-Synuclein oligomers can be detected directly in clinical samples, with minimal sample processing, by their ion current characteristics and successfully utilize this technology to differentiate cohorts of PD patients from healthy controls. The measurements indicate that detecting α-Syn oligomers present in CSF may potentially provide valuable insights into the progression and monitoring of Parkinson's disease

Quark Delocalization, Color Screening, and Nuclear Intermediate Range Attraction

We consider the effect of including quark delocalization and color screening, in the nonrelativistic quark cluster model, on baryon-baryon potentials and phase shifts. We find that the inclusion of these additional effects allows a good qualitative description of both.Comment: 10 pages, LaTeX, 4 figures in PostScript after text, LA-UR-91-215

Spin relaxation due to random Rashba spin-orbit coupling in GaAs (110) quantum wells

We investigate the spin relaxation due to the random Rashba spin-orbit coupling in symmetric GaAs (110) quantum wells from the fully microscopic kinetic spin Bloch equation approach. All relevant scatterings, such as the electron-impurity, electron--longitudinal-optical-phonon, electron--acoustic-phonon, as well as electron-electron Coulomb scatterings are explicitly included. It is shown that our calculation reproduces the experimental data by M\"uller {\em et al.} [Phys. Rev. Lett. {\bf 101}, 206601 (2008)] for a reasonable choice of parameter values. We also predict that the temperature dependence of spin relaxation time presents a peak in the case with low impurity density, which originates from the electron-electron Coulomb scattering.Comment: 5 pages, 2 figures, EPL in pres