The effect of manganese oxide on the sinterability of hydroxyapatite

The sinterability of manganese oxide (MnO2) doped hydroxyapatite (HA) ranging from 0.05 to 1 wt% was investigated. Green samples were prepared and sintered in air at temperatures ranging from 1000 to 1400 °C. Sintered bodies were characterized to determine the phase stability, grain size, bulk density, hardness, fracture toughness and Young's modulus. XRD analysis revealed that the HA phase stability was not disrupted throughout the sintering regime employed. In general, samples containing less than 0.5 wt% MnO2 and when sintered at lower temperatures exhibited higher mechanical properties than the undoped HA. The study revealed that all the MnO2-doped HA achieved >99% relative density when sintered at 1100–1250 °C as compared to the undoped HA which could only attained highest value of 98.9% at 1150 °C. The addition of 0.05 wt% MnO2 was found to be most beneficial as the samples exhibited the highest hardness of 7.58 GPa and fracture toughness of 1.65 MPam1/2 as compared to 5.72 GPa and 1.22 MPam1/2 for the undoped HA when sintered at 1000 °C. Additionally, it was found that the MnO2-doped samples attained E values above 110 GPa when sintered at temperature as low as 1000 °C if compared to 1050 °C for the undoped HA

Shape Synthesis in Mechanical Design

The shaping of structural elements in the area of mechanical design is a recurrent problem. The mechanical designer, as a rule, chooses what is believed to be the “simplest” shapes, such as the geometric primitives: lines, circles and, occasionally, conics. The use of higher-order curves is usually not even considered, not to speak of other curves than polynomials. However, the simplest geometric shapes are not necessarily the most suitable when the designed element must withstand loads that can lead to failure-prone stress concentrations. Indeed, as mechanical designers have known for a while, stress concentrations occur, first and foremost, by virtue of either dramatic changes in curvature or extremely high values thereof. As an alternative, we propose here the use of smooth curves that can be simply generated using standard concepts such as non-parametric cubic splines. These curves can be readily used to produce either extruded surfaces or surfaces of revolution.

Exploring the Dust Content of Galactic Winds with Herschel. I. NGC 4631

We present a detailed analysis of deep far-infrared observations of the nearby edge-on star-forming galaxy NGC 4631 obtained with the Herschel Space Observatory. Our PACS images at 70 and 160 um show a rich complex of filaments and chimney-like features that extends up to a projected distance of 6 kpc above the plane of the galaxy. The PACS features often match extraplanar Halpha, radio-continuum, and soft X-ray features observed in this galaxy, pointing to a tight disk-halo connection regulated by star formation. On the other hand, the morphology of the colder dust component detected on larger scale in the SPIRE 250, 350, and 500 um data matches the extraplanar H~I streams previously reported in NGC 4631 and suggests a tidal origin. The PACS 70/160 ratios are elevated in the central ~3.0 kpc region above the nucleus of this galaxy (the "superbubble"). A pixel-by-pixel analysis shows that dust in this region has a higher temperature and/or an emissivity with a steeper spectral index (beta > 2) than the dust in the disk, possibly the result of the harsher environment in the superbubble. Star formation in the disk seems energetically insufficient to lift the material out of the disk, unless it was more active in the past or the dust-to-gas ratio in the superbubble region is higher than the Galactic value. Some of the dust in the halo may also have been tidally stripped from nearby companions or lifted from the disk by galaxy interactions.Comment: Accepted for publication in The Astrophysical Journa

Broadband spin-controlled focusing via logarithmic-spiral nanoslits of varying width

This work presents analytical, numerical and experimental demonstrations of light diffracted through a logarithmic spiral (LS) nanoslit, which forms a type of switchable and focus-tunable structure. Owing to a strong dependence on the incident photon spin, the proposed LS-nanoslit converges incoming light of opposite handedness (to that of the LS-nanoslit) into a confined subwavelength spot, while it shapes light with similar chirality into a donut-like intensity profile. Benefitting from the varying width of the LS-nanoslit, different incident wavelengths interfere constructively at different positions, i.e., the focal length shifts from 7.5 μm (at λ = 632.8 nm) to 10 μm (at λ = 488 nm), which opens up new opportunities for tuning and spatially separating broadband light at the micrometer scale

Metabolism of ticagrelor in patients with acute coronary syndromes.

© The Author(s) 2018Ticagrelor is a state-of-the-art antiplatelet agent used for the treatment of patients with acute coronary syndromes (ACS). Unlike remaining oral P2Y12 receptor inhibitors ticagrelor does not require metabolic activation to exert its antiplatelet action. Still, ticagrelor is extensively metabolized by hepatic CYP3A enzymes, and AR-C124910XX is its only active metabolite. A post hoc analysis of patient-level (n = 117) pharmacokinetic data pooled from two prospective studies was performed to identify clinical characteristics affecting the degree of AR-C124910XX formation during the first six hours after 180 mg ticagrelor loading dose in the setting of ACS. Both linear and multiple regression analyses indicated that ACS patients presenting with ST-elevation myocardial infarction or suffering from diabetes mellitus are more likely to have decreased rate of ticagrelor metabolism during the acute phase of ACS. Administration of morphine during ACS was found to negatively influence transformation of ticagrelor into AR-C124910XX when assessed with linear regression analysis, but not with multiple regression analysis. On the other hand, smoking appears to increase the degree of ticagrelor transformation in ACS patients. Mechanisms underlying our findings and their clinical significance warrant further research.Peer reviewedFinal Published versio

Suzaku Observations of Local Ultraluminous Infrared Galaxies

We report the results from our analysis of {\it Suzaku} XIS (0.5-10 keV) and HXD/PIN (15-40 keV) observations of five well-known local ULIRGs: {\em IRAS} F05189-2524, {\em IRAS} F08572+3915, Mrk 273, PKS 1345+12, and Arp 220. The XIS observations of F05189-2524 and Mrk 273 reveal strong iron lines consistent with Fe K$\alpha$ and changes in spectral shapes with respect to previous {\it Chandra} and {\it XMM-Newton} observations. Mrk 273 is also detected by the HXD/PIN at $\sim$1.8-$\sigma$. For F05189-2524, modeling of the data from the different epochs suggests that the change in spectral shape is likely due to the central source switching off, leaving behind a residual reflection spectrum, or an increase in the absorbing column. An increase in the covering fraction of the absorber can describe the spectral variations seen in Mrk 273, although a reduction in the intrinsic AGN luminosity cannot be formally ruled out. The {\it Suzaku} spectra of Mrk 273 are well fit by a ~94% covering fraction model with a column density of $\sim10^{24}$ cm$^{-2}$. The absorption-corrected log[$L_{\rm 2-10 keV}$ / $L_{\rm IR}$] ratio is consistent with those found in PG Quasars. The 0.5-10 keV spectrum of PKS 1345+12 and Arp 220 seem unchanged from previous observations and their hard X-ray emission is not convincingly detected by the HXD/PIN. The large column density derived from CO observations and the large equivalent width of an ionized Fe line in Arp 220 can be reconciled by an ionized reflection model. F08572+3915 is undetected in both the XIS and HXD/PIN, but the analysis of unpublished {\em Chandra} data provides a new measurement at low energies.Comment: 37 pages including 4 tables and 10 figures. Accepted for publication in ApJ. It is tentatively scheduled to appear in the January 20, 2009 issue of Ap