Research Evaluation to Increase Impact

Research evaluation, undertaken throughout the life of the research activity, is an important tool for research managers. When correctly implemented, research evaluation can help to increase the success of existing and future research projects and programs, thereby increasing the social, economic and/or environmental impact of the research. The relationship between the life-cycle of the research project and the type of evaluation determines the appropriate type of evaluation to be undertaken. Given the value of research evaluation, and the recent development of user-friendly evaluation procedures and models, management of a R&D portfolio can benefit from increased evaluation effort at the project, program and organisational levels.Research evaluation, research-to-impact pathway, Research Methods/ Statistical Methods,

Population pressure and the microeconomy of land management in hills and mountains of developing countries:

Concerns about harmful environmental impacts are frequently raised in research and policy debates about population growth in the hills and mountains of developing countries. Although establishing wildlife corridors and biosphere reserves is important for preserving selected biodiverse habitats, for the vast majority of hilly-mountainous lands, the major ecological concerns are for the sustainability of local production systems and for watershed integrity. What matters for sustained use of those lands not only is the number of producers but also what, where and how they produce. Evidence from empirical research indicates that population growth in hills and mountains can lead to land enhancement, degradation, or aspects of both. This can be explained by extending induced innovation theory to address environmental impacts of intensification. Increases in the labor-land endowment ratios of households and in local land demand and labor supply make the opportunity cost of land relative to labor increase. As a result, people use hilly-mountainous land resources more intensively for production and consumption, thus tending to deplete resources and significantly alter habitats. But, at the same time, capital- and labor-intensive methods of replenishing or improving soil productivity may become economically more attractive, production systems that enhance the land if the expected discounted returns are greater than those of systems that degrade the land. Users will choose production systems that enhance the land if the expected discounted returns are greater than those of systems that degrade the land. In addition to population change, other factors—market conditions, local institutions and organizations, information and technology about resource management, and local ecological conditions—determine the returns from various production systems.Environmental impact analysis., Population density.,

Reciprocal Inhibition of Adiponectin and Innate Lung Immune Responses to Chitin and Aspergillus fumigatus

Chitin is a structural biopolymer found in numerous organisms, including pathogenic fungi, and recognized as an immune-stimulating pathogen associated molecular pattern by pattern recognition molecules of the host immune system. However, programming and regulation of lung innate immunity to chitin inhalation in the context of inhalation of fungal pathogens such as Aspergillus fumigatus is complex and our understanding incomplete. Here we report that the systemic metabolism-regulating cytokine adiponectin is decreased in the lungs and serum of mice after chitin inhalation, with a concomitant decrease in surface expression of the adiponectin receptor AdipoR1 on lung leukocytes. Constitutive lung expression of acidic mammalian chitinase resulted in decreased inflammatory cytokine gene expression and neutrophil recruitment, but did not significantly affect lung adiponectin transcription. Exogenous recombinant adiponectin specifically dampened airway chitin-mediated eosinophil recruitment, while adiponectin deficiency resulted in increased airway eosinophils. The presence of adiponectin also resulted in decreased CCL11-mediated migration of bone marrow-derived eosinophils. In contrast to purified chitin, aspiration of viable conidia from the high chitin-expressing A. fumigatus isolate Af5517 resulted in increased neutrophil recruitment and inflammatory cytokine gene expression in adiponectin-deficient mice, while no significant changes were observed in response to the isolate Af293. Our results identify a novel role for the adiponectin pathway in inhibition of lung inflammatory responses to chitin and A. fumigatus inhalation

Are we overusing IVF?

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